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Publikationen

2009

Original Articles

Asmus F, Langseth A, Doherty E, Nestor T, Munz M, Gasser T, Lynch T, King MD (2009) "Jerky" dystonia in children: spectrum of phenotypes and genetic testing. Mov Disord. 2009 Apr 15;24(5):702-9.

Asmus F, von Coelln R, Boertlein A, Gasser T, Mueller J. (2009) Reverse sensory geste in cervical dystonia. Mov Disord. 2009 Jan 30;24(2):297-300.

Bauer M, Kinkl N, Meixner A, Kremmer E, Riemenschneider M, Förstl H, Gasser T, Ueffing M. (2009) Prevention of interferon-stimulated gene expression using microRNA-designed hairpins. Gene Ther. 2009 Jan;16(1):142-7.

Bensimon G, Ludolph A, Agid Y, Vidailhet M, Payan C, Leigh PN; NNIPPS Study Group. (2009) Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study. Brain. 2009 Jan;132(Pt 1):156-71.

Breit S, Wächter T, Schöls S, Gasser T, Nägele T, Freudenstein D, Krüger R. (2009) Effective thalamic deep brain stimulation for neuropathic tremor in a patient with severe demyelinating neuropathy. J Neurol Neurosurg Psychiatry. J Neurol Neurosurg Psychiatry 80: 235-36.

Djarmati A, Hagenah J, Reetz K, Winkler S, Behrens MI, Pawlack H, Lohmann K, Ramirez A, Tadić V, Brüggemann N, Berg D, Siebner HR, Lang AE, Pramstaller PP, Binkofski F, Kostić VS, Volkmann J, Gasser T, Klein C. (2009) ATP13A2 variants in early-onset Parkinson's disease patients and controls. Mov Disord. 2009 Aug 24.

Evangelou E , Maraganore DM, Annesi G, Brighina L, Brice A, Elbaz A, Ferrarese C, Hadjigeorgiou GM, Krüger R, Lambert JC, Lesage S, Markopoulou K, Mellick GD, Meeus B, Pedersen NL, Quatrone A, Sharma M, Silburn PA, Tan EK, Van Broeckhoven C, Wirdefeldt K, Ioannidis JPA, for the Genetic Epidemiology of Parkinson’s disease (GEOPD) consortium. (2009) Non-replication of association for 6 polymorphisms from meta-analysis of genome-wide association studies of Parkinson’s disease: large-scale collaborative study. Am J Med Genet B Neuropsychiatr Genet.

Fernández-Santiago R, Sharma M, Berg D, Illig T, Anneser J, Meyer T, Ludolph A, Gasser T. No evidence of association of FLJ10986 and ITPR2 with ALS in a large German cohort.
Neurobiol Aging. 2009 May 21.

Fernández-Santiago R, Hoenig S, Lichtner P, Sperfeld AD, Sharma M, Berg D, Weichenrieder O, Illig T, Eger K, Meyer T, Anneser J, Münch C, Zierz S, Gasser T, Ludolph A. (2009) Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis. J Neurol. 2009 Aug;256(8):1337-42.

Fuchs J, Mueller JC, Lichtner P, Schulte C, Munz M, Berg D, Wüllner U, Illig T, Sharma M, Gasser T. (2009) The transcription factor PITX3 is associated with sporadic Parkinson's disease. Neurobiol Aging. 2009 May;30(5):731-8.

Golub Y, Berg D, Calne DB, Pfeiffer RF, Uitti RJ, Stoessl AJ, Wszolek ZK, Farrer MJ, Mueller JC, Gasser T, Fuchs J. (2009) Genetic factors influencing age at onset in LRRK2-linked Parkinson disease. Parkinsonism Relat Disord. 2009 Aug;15(7):539-41.

Hampel H, Ewers M, Bürger K, Annas P, Mörtberg A, Bogstedt A, Frölich L, Schröder J, Schönknecht P, Riepe MW, Kraft I, Gasser T, Leyhe T, Möller HJ, Kurz A, Basun H. (2009) Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study. J Clin Psychiatry. 2009 Jun;70(6):922-31.

Kahle PJ, Waak J, Gasser T. (2009) DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. Free Radic Biol Med. 2009 Aug 14.

Klein CL, Rovelli G, Springer W, Schall C, Gasser T, Kahle PJ. (2009) Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment. J Neurochem. 2009 Aug 27.

Koch A, Lehmann-Horn K, Dächsel JC, Gasser T, Kahle PJ, Lücking CB. (2009) Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells. Parkinsonism Relat Disord. 2009 Mar;15(3):220-5.

Leyhe T, Eschweiler GW, Stransky E, Gasser T, Annas P, Basun H, Laske C. (2009) Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease. J Alzheimers Dis. 2009 Mar;16(3):649-56.

Madžar D, Schulte C, Gasser T. (2009) Screening for LRRK2 R1441 mutations in a cohort of PSP patients from Germany. Eur J Neurol. 2009 Jun 15.

Maetzler W, Keller S, Michelis J, Koehler N, Stransky E, Becker C, Schulte C, Melms A, Gasser T, Berg D. (2009) No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases. Neurobiol Dis. 2009 Aug;35(2):296-301.

Maetzler W, Michelis J, Tomiuk J, Melms A, Becker C, Gasser T, Schulte C, Berg D. (2009) A single-nucleotide polymorphism of the osteopontin gene may contribute to a susceptibility to Lewy body disease. J Neural Transm. 2009 May;116(5):599-605.

Maetzler W, Liepelt I, Reimold M, Reischl G, Solbach C, Becker C, Schulte C, Leyhe T, Keller S, Melms A, Gasser T, Berg D. (2009) Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics. Neurobiol Dis. 2009 Apr;34(1):107-12.

Olanow CW, Rascol O, Hauser R, Feigin PD, Jankovic J, Lang A, Langston W, Melamed E, Poewe W, Stocchi F, Tolosa E; ADAGIO Study Investigators. (2009) A double-blind, delayed-start trial of rasagiline in Parkinson's disease. N Engl J Med. 2009 Sep 24;361(13):1268-78.

Robottom BJ, Weiner WJ, Asmus F, Huber H, Gasser T, Schöls S. (2009) Kick and rush: paradoxical kinesia in Parkinson disease. Neurology. 2009 Jul 28;73(4):328; author reply 328-9.

Rothfuss O, Fischer H, Hasegawa T, Maisel M, Leitner P, Miesel F, Sharma M, Bornemann A, Berg D, Gasser T, Patenge N. (2009) Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair. Hum Mol Genet. 2009 Oct 15;18(20):3832-50.

Scholz SW, Houlden H, Schulte C, Sharma M, Li A, Berg D, Melchers A, Paudel R, Gibbs JR, Simon-Sanchez J, Paisan-Ruiz C, Bras J, Ding J, Chen H, Traynor BJ, Arepalli S, Zonozi RR, Revesz T, Holton J, Wood N, Lees A, Oertel W, Wüllner U, Goldwurm S, Pellecchia MT, Illig T, Riess O, Fernandez HH, Rodriguez RL, Okun MS, Poewe W, Wenning GK, Hardy JA, Singleton AB, Gasser T. (2009) SNCA variants are associated with increased risk for multiple system atrophy. Ann Neurol. 2009 May;65(5):610-4.

Schulte C, Synofzik M, Gasser T, Schöls S. (2009) Ataxia with ophthalmoplegia or sensory neuropathy is frequently caused by POLG mutations. Neurology. 2009 Sep 15;73(11):898-900.

Sharma M, Lichtner P,  Krüger R, Berg D, Schulte C,  Illig T, Riess O, Gasser T. (2009) Further delineation of the association signal on chromosome 5 from the first whole genome association study in Parkinson's disease. Neurobiol Aging 30: 1706-9.

Sidransky E, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, Bar-Shira A, Berg D, Bras J, Brice A, Chen C-M, Clark LN, Condroyer C, de Marco EV, Dürr A, Eblan MJ, Fahn S, Farrer M, Fung H-C, Gan-Or Z, Gasser T, Gershoni-Baruch R, Giladi N, Griffith A, Gurevich T, Januario C, Kropp P, Lang AE, Lee-Chen G-J, Lesage S, Marder K, Mata IF, Mirelman A, Mitsui J, Mizuta I, Nalls MA, Nicoletti G, Oliveira C, Ottman R , Orr-Urtreger A, Pereira LV, Quattrone A, Rogaeva E, Rolfs A, Rosenbaum H, Rozenberg R, Samii A, Samaddar T, Schulte C, Sharma M, Singleton S, Spitz M, TanE-K, Tayebi N, Toda T, Troiano A, Tsuji S, Wittstock M, Wolfsberg TG, Wu Y-R, Zabetian CP, Zhao Y, Ziegler SG (2009) International multi-center analysis of glucocerebrosidase mutations in Parkinson disease. New Engl J Med.

Simon-Sanchez J, Schulte C, Bras CM, Sharma M, Gibbs R, Berg D, Paison-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Fedoroff M, Klein C, Goate A, Perlmutter J, Bonin M, Nalls MA, Illig T, Gieger C, Houlden H, Steffens M, Okun MS, Foote KD,  Fernandez HH, Schreiber S, Arepalli S, Zonozi R, Gwinn K, Lopez G, Chanock SJ, Schatzkin A, Park Y, Hollenbeck A, Gao J, Huang X, Wood NW, Lorenz D, Deuschl G, Chen H, Riess O, Hardy JA, Singleton AB, Gasser T.  (2009) Genome-wide association study reveals genetic risk underlying Parkinson’s disease. Nat Genet.

Soehn AS, Franck T, Biskup S, Giaime E, Melle C, Rott R, Cebo D, Kalbacher H, Ott E, Pahnke J, Meitinger T, Krüger R, Gasser T, Berg D, von Eggeling F, Engelender S, da Costa CA, Riess O. (2009)  Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease. Neurogenetics. 2009 Sep 3.

Wächter T, Weiss D, Breit S, Gasser T, Krüger R, Gharabaghi A. (2009) Severe muscular fasciculations as an uncommon side-effect due to microdefect of an extension wire in deep brain stimulation. Mov Disord. 2009 Aug 24.

Zimprich A, Schulte C, Reinthaler E, Haubenberger D, Balzar J, Lichtner P, El Tawil S, Edris S, Foki T, Pirker W, Katzenschlager R, Daniel G, Brücke T, Auff E, Gasser T. (2009) PARK11 gene (GIGYF2) variants Asn56Ser and Asn457Thr are not pathogenic for Parkinson's disease. Parkinsonism Relat Disord. 2009 Aug;15(7):532-4.

Reviews

Harbo HF, Finsterer J, Baets J, Van Broeckhoven C, Di Donato S, Fontaine B, De Jonghe P, Lossos A, Lynch T, Mariotti C, Schöls S, Spinazzola A, Szolnoki Z, Tabrizi SJ, Tallaksen C, Zeviani M, Burgunder JM, Gasser T; EFNS. (2009) EFNS guidelines on the molecular diagnosis of neurogenetic disorders: general issues, Huntington's disease, Parkinson's disease and dystonias. Eur J Neurol. 2009 Jul;16(7):777-85.

Ludolph AC, Kassubek J, Landwehrmeyer BG, Mandelkow E, Mandelkow EM, Burn DJ, Caparros-Lefebvre D, Frey KA, de Yebenes JG, Gasser T, Heutink P, Höglinger G, Jamrozik Z, Jellinger KA, Kazantsev A, Kretzschmar H, Lang AE, Litvan I, Lucas JJ, McGeer PL, Melquist S, Oertel W, Otto M, Paviour D, Reum T, Saint-Raymond A, Steele JC, Tolnay M, Tumani H, van Swieten JC, Vanier MT, Vonsattel JP, Wagner S, Wszolek ZK; Reisensburg Working Group for Tauopathies With Parkinsonism. (2009) Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options. Eur J Neurol. 2009 Mar;16(3):297-309.

Gasser T. (2009) Genomic and proteomic biomarkers for Parkinson disease. Neurology. 2009 Feb 17;72(7 Suppl):S27-31.

Gasser T. (2009) Mendelian forms of Parkinson's disease. Biochim Biophys Acta. 2009 Jul;1792(7):587-96.

Gasser T. (2009) Molecular pathogenesis of Parkinson disease: insights from genetic studies. Expert Rev Mol Med. 2009 Jul 27;11
Schulz JB, Boesch S, Bürk K, Dürr A, Giunti P, Mariotti C, Pousset F, Schöls S, Vankan P, Pandolfo M. (2009) Diagnosis and treatment of Friedreich ataxia: a European perspective. Nat Rev Neurol. 2009 Apr;5(4):222-34.


2008

Original Articles

Asmus F, Huber H, Gasser T, Schöls S (2008) Kick and rush: paradoxical kinesia in Parkinson disease. Neurology 71(9):695

Bach J, Sommer N, Möller JC, Oertel WH, Dodel R, Gasser T (2008) Parkinson’s syndrome in a young patient with Klinefelter’s syndrome--a case report. Movement Disorders 23(5):771-2

Bauer M, Szulc J, Meyer M, Jensen CH, Terki TA, Meixner A, Kinkl N, Gasser T, Aebischer P, Ueffing M (2008) Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons. Journal of Neurochemistry 104(4):1101-15

Breit S, Martin A, Lessmann L, Cerkez D, Gasser T, Schulz JB (2008) Bilateral changes in neuronal activity of the basal ganglia in the unilateral 6-hydroxydopamine rat model. Journal of Neuroscience Research 86(6):1388-96

Breit S, Spieker S, Schulz JB, Gasser T (2008) Long-term EMG recordings differentiate between parkinsonian and essential tremor. Journal of Neurology 255(1):103-11

Fuchs J, Tichopad A, Golub Y, Munz M, Schweitzer KJ, Wolf B, Berg D, Mueller JC, Gasser T (2008) Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain. The FASEB Journal 22(5):1327-34

Gaenslen A, Unmuth B, Godau J, Liepelt I, Di Santo A, Schweitzer KJ, Gasser T, Machulla H, Reimold M, Marek K, Berg D (2008) The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson’s disease: a prospective blinded study. Lancet Neurology 7(5):417-24

Gasser T (2008) Hunting for genes and mutations: it’s worth remembering the basics. Neurology 70(16 Pt 2):1373-4

Godau J, Wevers A, Gaenslen A, Di Santo A, Liepelt I, Gasser T, Berg D (2008) Sonographic abnormalities of brainstem structures in restless legs syndrome. Sleep Medicine 9(7):782-9

Haugarvoll K, Rademakers R, Kachergus JM, Nuytemans K, Ross OA, Gibson JM, Tan E, Gaig C, Tolosa E, Goldwurm S, Guidi M, Riboldazzi G, Brown L, Walter U, Benecke R, Berg D, Gasser T, Theuns J, Pals P, Cras P, De Deyn PP, Engelborghs S, Pickut B, Uitti RJ, Foroud T, Nichols WC, Hagenah J, Klein C, Samii A, Zabetian CP, Bonifati V, Van Broeckhoven C, Farrer MJ, Wszolek ZK (2008) Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease. Neurology 70(16 Pt 2):1456-60

Healy DG, Falchi M, O’Sullivan SS, Bonifati V, Durr A, Bressman S, Brice A, Aasly J, Zabetian CP, Goldwurm S, Ferreira JJ, Tolosa E, Kay DM, Klein C, Williams DR, Marras C, Lang AE, Wszolek ZK, Berciano J, Schapira AHV, Lynch T, Bhatia KP, Gasser T, Lees AJ, Wood NW (2008) Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson’s disease: a case-control study. Lancet Neurology 7(7):583-90

Hoepken H, Gispert S, Azizov M, Klinkenberg M, Ricciardi F, Kurz A, Morales-Gordo B, Bonin M, Riess O, Gasser T, Kögel D, Steinmetz H, Auburger G (2008) Parkinson patient fibroblasts show increased alpha-synuclein expression. Experimental Neurology 212(2):307-13
Kamm C, Fischer H, Garavaglia B, Kullmann S, Sharma M, Schrader C, Grundmann K, Klein C, Borggräfe I, Lobsien E, Kupsch A, Nardocci N, Gasser T (2008) Susceptibility to DYT1 dystonia in European patients is modified by the D216H polymorphism. Neurology 70(23):2261-2

Kamm C, Fogel W, Wächter T, Schweitzer K, Berg D, Kruger R, Freudenstein D, Gasser T (2008) Novel ATP1A3 mutation in a sporadic RDP patient with minimal benefit from deep brain stimulation. Neurology 70(16 Pt 2):1501-3

Kamm C, Nägele T, Mittelbronn M, Schöning M, Melms A, Gasser T, Schöls S (2008) Primary central nervous system vasculitis in a child mimicking parasitosis. Journal of Neurology 255(1):130-2

Köllensperger M, Geser F, Seppi K, Stampfer-Kountchev M, Sawires M, Scherfler C, Boesch S, Mueller J, Koukouni V, Quinn N, Pellecchia MT, Barone P, Schimke N, Dodel R, Oertel W, Dupont E, Østergaard K, Daniels C, Deuschl G, Gurevich T, Giladi N, Coelho M, Sampaio C, Nilsson C, Widner H, Sorbo FD, Albanese A, Cardozo A, Tolosa E, Abele M, Klockgether T, Kamm C, Gasser T, Djaldetti R, Colosimo C, Meco G, Schrag A, Poewe W, Wenning GK (2008) Red flags for multiple system atrophy. Movement Disorders 23(8):1093-9

Liepelt I, Maetzler W, Blaicher H, Gasser T, Berg D (2008) Treatment for dementia in parkinsonian syndromes. Efficacy of cholinesterase inhibitors. Der Nervenarzt 79(1):36-9, 42-6

Lücking CB, Lichtner P, Dichgans M, Illig T, Gieger C, Berg D, Gasser T (2008) Polymorphisms in the proteasomal subunit alpha4 are not associated with Parkinson’s disease. Journal of Neurology 255(3):441-2

Maetzler W, Reimold M, Liepelt I, Solbach C, Leyhe T, Schweitzer K, Eschweiler GW, Mittelbronn M, Gaenslen A, Uebele M, Reischl G, Gasser T, Machulla H, Bares R, Berg D (2008) [11C]PIB binding in Parkinson’s disease dementia. NeuroImage 39(3):1027-33

Prestel J, Gempel K, Hauser T, Schweitzer K, Prokisch H, Ahting U, Freudenstein D, Bueltmann E, Naegele T, Berg D, Klopstock T, Gasser T (2008) Clinical and molecular characterisation of a Parkinson family with a novel PINK1 mutation. Journal of Neurology 255(5):643-8

Ross OA, Braithwaite AT, Skipper LM, Kachergus J, Hulihan MM, Middleton FA, Nishioka K, Fuchs J, Gasser T, Maraganore DM, Adler CH, Larvor L, Chartier-Harlin M, Nilsson C, Langston JW, Gwinn K, Hattori N, Farrer MJ (2008) Genomic investigation of alpha-synuclein multiplication and parkinsonism. Annals of Neurology 63(6):743-50

Trenkwalder C, Boesch S, Ceballos-Baumann A, Dressler D, Eggert K, Gasser T, Honig H, Müller T, Reichmann H, Sieb JP, Storch A, Odin P, Poewe W (2008) Intermittent apomorphine injections as rescue therapy for advanced Parkinson’s disease. Consensus statement. Der Nervenarzt 79(4):475-9

von Coelln R, Raible A, Gasser T, Asmus F (2008) Ultrasound-guided injection of the iliopsoas muscle with botulinum toxin in camptocormia. Movement Disorders 23(6):889-92

Weber YG, Storch A, Wuttke TV, Brockmann K, Kempfle J, Maljevic S, Margari L, Kamm C, Schneider SA, Huber SM, Pekrun A, Roebling R, Seebohm G, Koka S, Lang C, Kraft E, Blazevic D, Salvo-Vargas A, Fauler M, Mottaghy FM, Münchau A, Edwards MJ, Presicci A, Margari F, Gasser T, Lang F, Bhatia KP, Lehmann-Horn F, Lerche H (2008) GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak. The Journal of Clinical Investigation 118(6):2157-68
Reviews

Biskup S, Gerlach M, Kupsch A, Reichmann H, Riederer P, Vieregge P, Wüllner U, Gasser T (2008) Genes associated with Parkinson syndrome. Journal of Neurology 255 Suppl 5:8-17

Gaenslen A, Gasser T, Berg D (2008) Nutrition and the risk for Parkinson’s disease: review of the literature. Journal of Neural Transmission (Vienna, Austria: 1996) 115(5):703-13


Books, book chapters, and proceedings

Gasser T (2008) Biomarker für neurodegenerative Erkrankungen. In: Schmitz G, Endres S, Götte D (eds): Biomarker: Bedeutung für medizinischen Fortschritt und Nutzenbewertung. Schattauer Verlag, Stuttgart, New York, 156-168


2007

Original Articles

Asmus F, Devlin A, Munz M, Zimprich A, Gasser T, Chinnery PF (2007) Clinical differentiation of genetically proven benign hereditary chorea and myoclonus-dystonia. Movement Disord 22(14):2104-9

Asmus F, Hjermind LE, Dupont E, Wagenstaller J, Haberlandt E, Munz M, Strom TM, Gasser T (2007) Genomic deletion size at the epsilon-sarcoglycan locus determines the clinical phenotype. Brain 130(10):2736-45

Bogaerts V, Engelborghs S, Kumar-Singh S, Goossens D, Pickut B, van der Zee J, Sleegers K, Peeters K, Martin JJ, Del-Favero J, Gasser T, Dickson DW, Wszolek ZK, De Deyn PP, Theuns J, Van Broeckhoven C (2007) A novel locus for dementia with Lewy bodies: a clinically and genetically heterogeneous disorder. Brain 130(9):2277-91

Breit S, Bouali-Benazzouz R, Popa RC, Gasser T, Benabid AL, Benazzouz A (2007) Effects of 6-hydroxydopamine-induced severe or partial lesion of the nigrostriatal pathway on the neuronal activity of pallido-subthalamic network in the rat. Exp Neurol 205(1):36-47

Brötz D, Eichner M, Gasser T, Weller M, Steinbach JP (2007) Radicular and nonradicular back pain in Parkinson’s disease: a controlled study. Movement Disord 22(6):853-6

Eggert K, Wullner U, Antony G, Gasser T, Janetzky B, Klein C, Schöls S, Oertel W (2007) Data protection in biomaterial banks for Parkinson’s disease research: the model of GEPARD (Gene Bank Parkinson’s Disease Germany). Movement Disord 22(5):611-8

Exner N, Treske B, Paquet D, Holmström K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Krüger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, Kahle PJ, Schmid B, Haass C (2007) Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci 27(45):12413-8

Fuchs J, Nilsson C, Kachergus J, Munz M, Larsson EM, Schule B, Langston JW, Middleton FA, Ross OA, Hulihan M, Gasser T, Farrer MJ (2007) Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication. Neurology 68(12):916-22

Haubenberger D, Bonelli S, Hotzy C, Leitner P, Lichtner P, Samal D, Katzenschlager R, Djamshidian A, Brucke T, Steffelbauer M, Bancher C, Grossmann J, Ransmayr G, Strom TM, Meitinger T, Gasser T, Auff E, Zimprich A (2007) A novel LRRK2 mutation in an Austrian cohort of patients with Parkinson’s disease. Movement Disord 22(11):1640-3

Kamm C, Mayer P, Sharma M, Niemann G, Gasser T (2007) New family with paroxysmal exercise-induced dystonia and epilepsy. Movement Disord 22(6):873-7

Litvan I, Chesselet MF, Gasser T, Di Monte DA, Parker D Jr, Hagg T, Hardy J, Jenner P, Myers RH, Price D, Hallett M, Langston WJ, Lang AE, Halliday G, Rocca W, Duyckaerts C, Dickson DW, Ben-Shlomo Y, Goetz CG, Melamed E (2007) The etiopathogenesis of Parkinson disease and suggestions for future research. Part II. J Neuropath Exp Neur 66(5):329-36

Litvan I, Halliday G, Hallett M, Goetz CG, Rocca W, Duyckaerts C, Ben-Shlomo Y, Dickson DW, Lang AE, Chesselet MF, Langston WJ, Di Monte DA, Gasser T, Hagg T, Hardy J, Jenner P, Melamed E, Myers RH, Parker D Jr, Price DL (2007) The etiopathogenesis of Parkinson disease and suggestions for future research. Part I. J Neuropath Exp Neur 66(4):251-7

Mätzler W, Berg D, Schalamberidze N, Melms A, Schott K, Müller JC, Liaw L, Gasser T, Nitsch C (2007) Osteopontin is elevated in Parkinson’s disease and its absence leads to reduced neurodegeneration in the MPTP model. Neurobiol Dis 25(3):473-82

Mätzler W, Nagele T, Gasser T, Krüger R (2007) Acute parkinsonism with corresponding lesions in the basal ganglia after heroin abuse. Neurology 68(6):414

Ohta E, Hasegawa K, Gasser T, Obata F (2007) Independent occurrence of I2020T mutation in the kinase domain of the leucine rich repeat kinase 2 gene in Japanese and German Parkinson’s disease families. Neurosci Lett 417(1):21-3

Rosenberger A, Sharma M, Muller-Myhsok B, Gasser T, Bickeboller H (2007) Meta analysis of whole-genome linkage scans with data uncertainty: an application to Parkinson’s disease. BMC Genet 8(44):1-9

Rosenkranz D, Weyer S, Tolosa E, Gaenslen A, Berg D, Leyhe T, Gasser T, Stoltze L (2007) Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration. J Neuroimmunol 188(1):117-27

Schweitzer KJ, Behnke S, Liepelt I, Wolf B, Grosser C, Godau J, Gaenslen A, Brüssel T, Wendt A, Abel F, Müller A, Gasser T, Berg D (2007) Cross-sectional study discloses a positive family history for Parkinson’s disease and male gender as epidemiological risk factors for substantia nigra hyperechogenicity. J Neural Transm 114(9):1167-71

Schweitzer KJ, Brüssel T, Leitner P, Krüger R, Bauer P, Woitalla D, Tomiuk J, Gasser T, Berg D (2007) Transcranial ultrasound in different monogenetic subtypes of Parkinson’s disease. J Neurol 254(5):613-16

Taylor JP, Hulihan MM, Kachergus JM, Melrose HL, Lincoln SJ, Hinkle KM, Stone JT, Ross OA, Hauser R, Aasly J, Gasser T, Payami H, Wszolek ZK, Farrer MJ (2007) Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson‘s disease. Neurogenetics 8(2):95-102

Valkovic P, Krastev G, Mako M, Leitner P, Gasser T (2007) A unique case of coincidence of early onset Parkinson‘s disease and multiple sclerosis. Movement Disord 22(15)2278-81

Reviews

Gasser T (2007) Update on the genetics of Parkinson‘s disease. Movement Disord 22(S17):S343-50

Liepelt I, Mätzler W, Blaicher HP, Gasser T, Berg D (2007) Treatment of dementia in parkinsonian syndromes with cholinesterase inhibitors. Dement Geriatr Cogn 23(6):351-67

Liepelt I, Mätzler W, Blaicher HP, Gasser T, Berg D (2007) Behandlung der Demenz bei Parkinson-Syndromen. Nervenarzt 79(1):36-46

Books, book chapters, and proceedings

Gasser T (2007) Molekulargenetische Diagnostik und Gentherapie. In: Brandt T, Dichgans J, Diener HC (eds) Therapie und Verlauf neurologischer Erkrankungen, 5th edition. Kohlhammer, Stuttgart, 1519-38

Gasser T (2007) Genetics of Parkinson’s disease. In: Jankowic J, Tolosa E (eds) Parkinson’s disease and movement disorders, 5th edition. Liptincott, Williams and Wilkins, Philadelphia, 93-101

Gasser T, Danek A (2007) Chorea. In: Brandt T, Dichgans J, Diener HC (eds) Therapie und Verlauf neurologischer Erkrankungen, 5. Auflage. Kohlhammer, Stuttgart, 1089-97

Gasser T (2007) Molekulargenetische Diagnostik und Gentherapie. In: Brandt T, Dichgans J, Diener HC (eds) Therapie und Verlauf neurologischer Erkrankungen, 5th edition. Kohlhammer, Stuttgart, 1519-38

Schulz JB, Gasser T (2007) Parkinson-Syndrome. In: Brandt T, Dichgans J, Diener HC (eds) Therapie und Verlauf neurologischer Erkrankungen, 5. Auflage. Kohlhammer, Stuttgart, 961-1007


2006

Original Articles

Bender A, Koch W, Elstner M, Schombacher Y, Bender J, Moeschl M, Gekeler F, Müller-Myhsok B, Gasser T, Tatsch K, Klopstock T (2006) Creatine supplementation in Parkinson disease: A placebo-controlled randomized pilot trial. Neurology 67:1262-4

Breit S, Lessmann L, Unterbrink D, Popa RC, Gasser T, Schulz JB (2006) Lesion of the pedunculopontine nucleus reverses hyperactivity of the subthalamic nucleus and substantia nigra pars reticulata in a 6-hydroxydopamine rat model. Eur J Neurosci 24(8):2275-82

Depboylu C, Lohmuller F, Du Y, Riemenschneider M, Kurz A, Gasser T, Muller U, Dodel RC (2006) Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoproteinreceptor-associated protein and the genetic risk for developing Alzheimer's disease. Neurosci Lett 400(3):187-90

Deutschlander A, Asmus F, Marelli E, Klopstock T, Gasser T, Botzel K (2006) Excellent response to  pomorphine in Parkinsonism with optic atrophy unresponsive to oral antiparkinsonian medication. Movement Disord 21(9):1523-5

Di Fonzo A, Tassorelli C, De Mari M, Chien HF, Ferreira J, Rohe CF, Riboldazzi G, Antonini A, Albani G, Mauro A, Marconi R, Abbruzzese G, Lopiano L, Fincati E, Guidi M, Marini P, Stocchi F, Onofrj M, Toni V, Tinazzi M, Fabbrini G, Lamberti P, Vanacore N, Meco G, Leitner P, Uitti RJ, Wszolek ZK, Gasser T, Simons EJ, Breedveld GJ, Goldwurm S, Pezzoli G, Sampaio C, Barbosa E, Martignoni E, Oostra BA, Bonifati V (2006) Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease. Eur J Hum Genet 14(3):322-31

Elstner M, Bettecken T, Wasner M, Anneser F, Dichgans M, Meitinger T, Gasser T, Klopstock T( 2006) Familial carpal tunnel syndrome: further evidence for a geneticcontribution. Clin Genet 69(2):179-82

Fernandez-Santiago R, Sharma M, Mueller C, Gohlke H, Illig T, Anneser J, Münch C, Ludolph A, Kamm C, Gasser T (2006) Possible gender-dependent association of vascular endothelial growth factor (VEGF) gene and ALS. Neurology 66:1929-31

Gasser T (2006) Molecular genetic findings in LRRK2 American, Canadian and German families. J Neural Transm-Supp 70:231-4

Kamm C, Asmus F, Mueller J, Mayer P, Sharma M, Muller UJ, Beckert S, Ehling R, Illig T, Wichmann HE, Poewe W, Mueller JC, Gasser T (2006) Strong genetic evidence for association of TOR1A/TOR1B with idiopathic dystonia. Neurology 67(10):1857-9

Leyhe T, Schule R, Schwarzler F, Gasser T, Haarmeier T (2006) Second primary tumor in anti-Ma1/2-positive paraneoplastic limbicencephalitis. J Neuro-Oncol 78(1):49-51

Liebetanz KM, Winkelmann J, Trenkwalder C, Putz B, Dichgans M, Gasser T, Muller-Myhsok B (2006) RLS3: fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity. Neurology 67(2):320-1

Ozawa T, Healy DG, Abou-Sleiman PM, Ahmadi KR, Quinn N, Lees AJ, Shaw K, Wullner U, Berciano J, Moller JC, Kamm C, Burk K, Josephs KA, Barone P, Tolosa E, Goldstein DB, Wenning G, Geser F, Holton JL, Gasser T, Revesz T, Wood NW (2006) The a-synuclein gene in multiple system atrophy. J Neurol Neurosur PS 77:464-7

Prestel J, Schweitzer K, Hofer A, Gasser T, Berg D (2006) Predictive value of transcranial sonography in the diagnosis of Parkinson's disease. Movement Disord 21:1763-5

Schneider SA, Mohire MD, Trender-Gerhard I, Asmus F, Sweeney M, Davis M, Gasser T, Wood NW, Bhatia KP (2006) Familial dopa-responsive cervical dystonia. Neurology 66:599-601

Schulte C, Sharma M, Mueller JC, Lichtner P, Prestel J, Berg D, Gasser T (2006) Comprehensive association analysis of the NOS2A gene with Parkinson disease. Neurology 67(11)2080-2

Sharma M, Mueller JC, Zimprich A, Lichtner P, Hofer A, Leitner P, Maass S, Berg D, Dürr A, Bonifati V, De Michele G, Oostra B, Brice A, Wood NW, Müller-Myhsok B, Gasser T (2006) The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations. J Med Genet 43:557-62

Reviews

Albanese A, Barnes MP, Bhatia KP, Fernandez-Alvarez E, Filippini G, Gasser T, Krauss JK, Newton A, Rektor I, Savoiardo M, Valls-Sole J (2006) A systematic review on the diagnosis and treatment of primary (idiopathic)dystonia and dystonia plus syndromes: report of an EFNS/MDS-ES Task Force. Eur J Neurol 13(5):433-44