Neurodegeneration - Postdoctoral Fellowship

The Laboratory of Functional Neurogenetics at the Hertie Institute for Clinical Brain
Research and German Center for Neurodegenerative Diseases, Tübingen (Germany) offers
(starting Oct. 2011 or later) a full time
Postdoctoral Position.
The position is funded by the German Research Council (DFG) and supported by the National Competence Network “Degenerative Dementias”. Research aims to elucidate the molecular and cellular biology of TDP-43 and FUS/TLS, which are linked neuropathologically and genetically to frontotemporal dementia and amyotrophic lateral sclerosis. Approaches include RNA interference and transfections, mRNA and miRNA microarray validations, protein biochemistry and RNA binding and processing assays, reporter assays, molecular and cellular biology in cell lines and primary cultures, and advanced imaging technologies.
We are looking for a highly motivated, team-oriented enthusiastic individual with a strong background in molecular and cellular biology. Preference is given to applicants who have experience with RNA binding proteins. Experience with animal models, such as Drosophila, would be advantageous. Candidates with a PhD in life sciences (e.g. biology, biochemistry, neuroscience) are invited to send applications to:
Prof. Philipp Kahle, PhD
Laboratory of Functional Neurogenetics
Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative
Diseases
Faculty of Medicine, University of Tübingen
Otfried Müller Str. 27
72076 Tübingen, Germany
E-Mail: philipp.kahle@uni-tuebingen.de
www.hih-tuebingen.de/en/funct-neurogenet/

Key References:
Fiesel et al. (2010) Knockdown of transactive response DNA-binding protein (TDP-43) downregulates
histone deacetylase 6. EMBO J. 29, 209-221
Mackenzie et al. (2010) TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal
dementia. Lancet Neurol. 9, 995-1007
Fiesel & Kahle (2011) TDP-43 and FUS/TLS: Cellular functions and implications for
neurodegeneration. FEBS J. [Epub ahead of print]