Publications

Original papers:

Genetics, pathophysiology and therapy of idiopathic epilepsies and other paroxysmal diseases of the nervous system

Brodie MJ, Covanis A, Gil-Nagel A, Lerche H, Perucca E, Sills GJ, White HS.
Antiepileptic drug therapy: Does mechanism of action matter? Epilepsy Behav. 2011
Aug;21(4):331-41. Epub 2011 Jul 16. PubMed PMID: 21763207.

Maljevic S, Naros G, Yalçin O, Blazevic D, Loeffler H, Cağlayan H, Steinlein
OK, Lerche H. Temperature and pharmacological rescue of a folding-defective,
dominantl-negative K(V) 7.2 mutation associated with neonatal seizures. Hum
Mutat. 2011 Oct;32(10):E2283-93. doi: 10.1002/humu.21554. PubMed PMID: 21913284

Weber YG, Kamm C, Suls A, Kempfle J, Kotschet K, Schüle R, Wuttke TV, Maljevic
S, Liebrich J, Gasser T, Ludolph AC, Van Paesschen W, Schöls L, De Jonghe P,
Auburger G, Lerche H. Paroxysmal choreoathetosis/spasticity (DYT9) is caused by a GLUT1 defect. Neurology. 2011 Sep 6;77(10):959-64. Epub 2011 Aug 10. PubMed PMID:21832227. Supplementary Video1, Video 2

Brodie MJ, Lerche H, Gil-Nagel A, Elger C, Hall S, Shin P, Nohria V, Mansbach
H; RESTORE 2 Study Group. Efficacy and safety of adjunctive ezogabine
(retigabine) in refractory partial epilepsy. Neurology. 2010 Nov
16;75(20):1817-24. Epub 2010 Oct 13. PubMed PMID: 20944074

 Wimmer VC, Reid CA, Mitchell S, Richards KL, Scaf BB, Leaw BT, Hill EL,
Royeck M, Horstmann MT, Cromer BA, Davies PJ, Xu R, Lerche H, Berkovic SF, Beck H, Petrou S. Axon initial segment dysfunction in a mouse model of genetic
epilepsy with febrile seizures plus. J Clin Invest. 2010 Aug 2;120(8):2661-71.
doi: 10.1172/JCI42219. Epub 2010 Jul 12. PubMed PMID: 20628201; PubMed Central PMCID: PMC2912193

Liao Y, Anttonen AK, Liukkonen E, Gaily E, Maljevic S, Schubert S, Bellan-Koch
A, Petrou S, Ahonen VE, Lerche H*, Lehesjoki AE*. SCN2A mutation associated with neonatal epilepsy, late-onset episodic ataxia, myoclonus, and pain. Neurology. 2010 Oct 19;75(16):1454-8. PubMed PMID: 20956790., *corresponding authors.

Muhle H, von Spiczak S, Gaus V, Kara S, Helbig I, Hampe J, Franke A, Weber Y,
Lerche H, Kleefuss-Lie AA, Elger CE, Schreiber S, Stephani U, Sander T. Role of
GRM4 in idiopathic generalized epilepsies analysed by genetic association and
sequence analysis. Epilepsy Res. 2010 May;89(2-3):319-26. Epub 2010 Mar 24.
PubMed PMID: 20338729

Weber YG, Roebling R, Kassubek J, Hoffmann S, Rosenbohm A, Wolf M, Steinbach P, Jurkat-Rott K, Walter H, Reske SN, Lehmann-Horn F, Mottaghy FM, Lerche H. Comparative analysis of brain structure, metabolism, and cognition in myotonic dystrophy 1 and 2. Neurology. 2010 Apr 6;74(14):1108-17. Epub 2010 Mar 10. PubMed PMID: 20220122.

Jurkat-Rott K, Lerche H, Weber Y, Lehmann-Horn F. Hereditary channelopathies
in neurology. Adv Exp Med Biol. 2010;686:305-34. Review. PubMed PMID: 20824453

Liao Y, Deprez L, Maljevic S, Pitsch J, Claes L, Hristova D, Jordanova A,
Ala-Mello S, Bellan-Koch A, Blazevic D, Schubert S, Thomas EA, Petrou S, Becker
AJ, De Jonghe P, Lerche H. Molecular correlates of age-dependent seizures in an
inherited neonatal-infantile epilepsy. Brain. 2010 May;133(Pt 5):1403-14. Epub
2010 Apr 5. PubMed PMID: 20371507

de Kovel CG, Trucks H, Helbig I, Mefford HC, Baker C, Leu C, Kluck C, Muhle H, von Spiczak S, Ostertag P, Obermeier T, Kleefuß-Lie AA, Hallmann K, Steffens M, Gaus V, Klein KM, Hamer HM, Rosenow F, Brilstra EH, Kasteleijn-Nolst Trenité D, Swinkels ME, Weber YG, Unterberger I, Zimprich F, Urak L, Feucht M, Fuchs K, Møller RS, Hjalgrim H, De Jonghe P, Suls A, Rückert IM, Wichmann HE, Franke A, Schreiber S, Nürnberg P, Elger CE, Lerche H, Stephani U, Koeleman BP, Lindhout D, Eichler EE, Sander T. Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies. Brain 2009. [Epub ahead of print]

Suls A*, Mullen SA*, Weber YG*, Verhaert K, Ceulemans B, Guerrini R, Wuttke TV, Salvo-Vargas A, Deprez L, Claes LR, Jordanova A, Berkovic SF, Lerche H, De Jonghe P, Scheffer IE. Early-onset absence epilepsy caused by mutations in the glucose transporter GLUT1. Ann Neurol 2009;66:415-9, *contributed equally

Kleefuss-Lie A, Friedl W, Cichon S, Haug K, Warnstedt M, Alekov A, Sander T, Ramirez A, Poser B, Maljevic S, Hebeisen S, Kubisch C, Rebstock J, Horvath S, Hallmann K, Dullinger JS, Rau B, Haverkamp F, Beyenburg S, Schulz H, Janz D, Giese B, Müller-Newen G, Propping P, Elger CE, Fahlke C, Lerche H. CLCN2 variants in idiopathic generalized epilepsy. Nat Genet 2009;41:954-5.

Schneider SA, Paisan-Ruiz C, Garcia-Gorostiaga I, Quinn NP, Weber YG, Lerche H, Hardy J, Bhatia KP. GLUT1 gene mutations cause sporadic paroxysmal exercise-induced dyskinesias. Mov Disord 2009;24:1684-8.

Dibbens LM, Mullen S, Helbig I, Mefford HC, Bayly MA, Bellows S, Leu C, Trucks H, Obermeier T, Wittig M, Franke A, Caglayan H, Yapici Z; EPICURE Consortium, Sander T, Eichler EE, Scheffer IE, Mulley JC, Berkovic SF. Familial and sporadic 15q13.3 microdeletions in idiopathic generalized epilepsy: precedent for disorders with complex inheritance. Hum Mol Genet 2009;18:3626-31.

Saint-Martin C, Gauvain G, Teodorescu G, Gourfinkel-An I, Fedirko E, Weber YG, Maljevic S, Ernst JP, Garcia-Olivares J, Fahlke C, Nabbout R, LeGuern E, Lerche H, Poncer JC, Depienne C. Two novel CLCN2 mutations accelerating chloride channel deactivation are associated with idiopathic generalized epilepsy. Hum Mutat 2009;30:397-405.

Helbig I, Mefford HC, Sharp AJ, Guipponi M, Fichera M, Franke A, Muhle H, de Kovel C, Baker C, von Spiczak S, Kron KL, Steinich I, Kleefuss-Lie AA, Leu C, Gaus V, Schmitz B, Klein KM, Reif PS, Rosenow F, Weber Y, Lerche H, Zimprich F, Urak L, Fuchs K, Feucht M, Genton P, Thomas P, Visscher F, de Haan GJ, Møller RS, Hjalgrim H, Luciano D, Wittig M, Nothnagel M, Elger CE, Nürnberg P, Romano C, Malafosse A, Koeleman BP, Lindhout D, Stephani U, Schreiber S, Eichler EE, Sander T. 15q13.3 microdeletions increase risk of idiopathic generalized epilepsy. Nat Genet 2009;41:160-2.

Suls A, Dedeken P, Goffin K, Van Esch H, Dupont P, Cassiman D, Kempfle J, Wuttke TV, Weber Y, Lerche H, Afawi Z, Vandenberghe W, Korczyn AD, Berkovic SF, Ekstein D, Kivity S, Ryvlin P, Claes LR, Deprez L, Maljevic S, Vargas A, Van Dyck T, Goossens D, Del-Favero J, Van Laere K, De Jonghe P, Van Paesschen W. Paroxysmal exercise-induced dyskinesia and epilepsy is due to mutations in SLC2A1, encoding the glucose transporter GLUT1. Brain 2008;131:1831-44.

Weber YG, Jacob M, Weber G, Lerche H. A BFIS-like syndrome with late onset and febrile seizures: suggestive linkage to chromosome 16p11.2-16q12.1. Epilepsia. 2008;49:1959-64.

Weber YG, Storch A, Wuttke TV, Brockmann K, Kempfle J, Maljevic S, Margari L, Kamm C, Schneider SA, Huber SM, Pekrun A, Roebling R, Seebohm G, Koka S, Lang C, Kraft E, Blazevic D, Salvo-Vargas A, Fauler M, Mottaghy FM, Münchau A, Edwards MJ, Presicci A, Margari F, Gasser T, Lang F, Bhatia KP, Lehmann-Horn F, Lerche H. GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak. J Clin Invest. 2008;118:2157-68.

Wuttke TV, Penzien J, Fauler M, Seebohm G, Lehmann-Horn F, Lerche H, Jurkat-Rott K. Neutralization of a negative charge in the S1-S2 region of the K_V7.2 (KCNQ2) channel affects voltage-dependent activation in neonatal epilepsy. J Physiol. 2008;586:545-55.

Wuttke TV, Jurkat-Rott K, Paulus W, Garncarek M, Lehmann-Horn F, Lerche H. Peripheral nerve hyperexcitability due to dominant-negative KCNQ2 mutations. Neurology 2007;69:2045-53.

Hempelmann A, Cobilanschi J, Heils A, Muhle H, Stephani U, Weber Y, Lerche H, Sander T. Lack of evidence of an allelic association of a functional GABRB3 exon 1a promoter polymorphism with idiopathic generalized epilepsy. Epilepsy Res. 2007;74:28-32.

Hunter*, Maljevic M*, Shankar A, Siegel A, Olson L, Weissman B, Holt P, Lerche H§, Escayg A§. Subthreshold changes of voltage-dependent activation of the K_V7.2 channel in neonatal epilepsy. Neurobiol Dis 2006;24:194-201. *contributed equally, §corresponding authors.

Hempelmann A, Taylor KP, Heils A, Lorenz S, Prud'Homme JF, Nabbout R, Dulac O, Rudolf G, Zara F, Bianchi A, Robinson R, Gardiner RM, Covanis A, Lindhout D, Stephani U, Elger CE, Weber YG, Lerche H, Nürnberg P, Kron KL, Scheffer IE, Mulley JC, Berkovic SF, Sander T. Exploration of the Genetic Architecture of Idiopathic Generalized Epilepsies. Epilepsia 2006;47:1682-90.

Maljevic S, Krampfl K, Cobilanschi J, Tilgen N, Beyer S, Weber YG, Schlesinger F, Ursu D, Melzer W, Cossette P, Bufler J, Lerche H*, Heils A*. A mutation in the GABA_A receptor alpha₁-subunit is associated with absence epilepsy. Ann Neurol 2006;59:983-7. *corresponding authors.

Krampfl K, Maljevic S, Cossette P, Ziegler E, Rouleau GA, Lerche H*, Bufler J. Molecular analysis of the A322D mutation in the a1-subunit of the GABAA receptor causing juvenile myoclonic epilepsy. Eur J Neurosci 2005;22:10-20. *corresponding author.

Weber YG, Berger A, Hallbach A, Bebek N, Maier S, Karafyllakes S, Fukuyama Y, Hickel C, Kurlemann G, Neubauer B, Osawa M, Püst B, Rating D, Saito K, Stephani U, Lehmann-Horn F, Jurkat-Rott K, Lerche H. Benign familial infantile convulsions: Linkage to chromosome 16p12-q12 in 14 families. Epilepsia 2004;45:601-9.

Lerche H, Weber YG, Baier H, Jurkat-Rott K, Kraus de Camargo O, Ludolph AC, Bode H, Lehmann-Horn F. Generalized epilepsy with febrile seizures plus: Further heterogeneity in a large family. Neurology 2001;57:1191-8.

Alekov AK, Rahman MM, Mitrovic N, Lehmann-Horn F, Lerche H. Enhanced inactivation and acceleration of activation of the sodium channel associated with epilepsy in man. Eur J Neurosci 2001;13:2171-6.

Alekov AK, Rahman MM, Mitrovic N, Lehmann-Horn F, Lerche H. A sodium channel mutation causing epilepsy in man exhibits subtle defects in fast inactivation and activation in vitro. J Physiol 2000;529:533-9.

Lerche H, Biervert C, Alekov AK, Schleithoff L, Lindner M, Klingler W, Bretschneider F, Mitrovic N, Jurkat-Rott K, Bode H, Lehmann-Horn F, Steinlein OK. A reduced K+ current due to a novel mutation in KCNQ2 causes neonatal convulsions. Ann Neurol 1999;46:305-12.

Gating, pharmacology and subcellular localizations of ion channels

Lerche C, Bruhova I, Lerche H, Steinmeyer K, Wie AD, Strutz-Seebohm N, Lang F, Busch AE, Zhorov BS, Seebohm G. Chromanol 293B binding in KCNQ1 (K_V7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter. Mol Pharm 2007;71:1503-11.

Geiger J, Weber YG, Landwehrmeyer B, Sommer C, Lerche H. Immunohistochemical analysis of KCNQ3 potassium channels in mouse brain. Neurosci Lett 2006;400:101-4.

Weber YG, Geiger J, Kaempchen K, Lindenberg K, Landwehrmeyer B, Sommer C, Lerche H. Immunohistochemical analysis of KCNQ2 potassium channels in adult and developing mouse brain. Brain Res 2006;1077:1-6.

Wuttke TV, Seebohm G, Bail S, Maljevic S, Lerche H. The new anticonvulsant Retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol Pharm 2005;67:1009-17.

Maljevic S, Lerche C, Seebohm G, Alekov AK, Busch AE, Lerche H. C-terminal interaction of KCNQ2 and KCNQ3 K+ channels. J Physiol 2003;548:353-60.

Sodium channelopathies of skeletal muscle and molecular mechanism of sodium channel inactivation

The YK, Fernandez J, Popa MO, Timmer J, Lerche H. Modeling of single non-inactivating Na⁺ channels: evidence for two open and several fast inactivated states. Biophys J 2006;90:3511-22.

Popa MO, Alekov AK, Bail S, Lehmann-Horn F, Lerche H. Cooperative effect of S4-S5 loops in domains D3 and D4 on fast inactivation of the sodium channel. J Physiol 2004;561:39-51.

Jurkat-Rott K, Mitrovic N, Hang C, Kouzmenkine A, Iaizzo P, Herzog J, Lerche H, Nicole S, Vale-Santos J, Chauveau D, Fontaine B, Lehmann-Horn F. Voltage sensor sodium channel mutations cause hypokalemic periodic paralysis type 2 by enhanced inactivation and reduced current. Proc Natl Acad Sci USA 2000;97:9549-54.

Peter W, Mitrovic N, Schiebe W, Lehmann-Horn F, Lerche H. A human muscle sodium channel mutation in the voltage sensor IV/S4 affects channel block by the pentapeptide KIFMK. J Physiol 1999;518:13-22.

Mitrovic N, George AL, Rüdel R, Lehmann-Horn F, Lerche H. Mutant channels contribute < 50% to Na⁺ current in paramyotonia congenita muscle. Brain 1999;122:1085-92.

Lerche H, Peter W, Fleischhauer R, Pika-Hartlaub U, Malina T, Mitrovic N, Lehmann-Horn F. Role in fast inactivation of the IV/S4-S5 loop of the human muscle Na+ channel probed by cysteine mutagenesis. J Physiol 1997;505:345-52.

Lerche H, Mitrovic N, Dubowitz V, Lehmann-Horn F. Paramyotonia congenita: The R1448P sodium channel mutation in adult human skeletal muscle. Ann Neurol 1996;39:599-608.

Mitrovic N, George AL, Lerche H, Wagner S, Fahlke Ch, Lehmann-Horn F. Different effects on gating of three myotonia causing mutations in the inactivation gate of the human muscle sodium channel. J Physiol 1995;487:107-14.

Lerche H, Heine R, Pika U, George AL Jr, Mitrovic N, Browatzki M, Weiss T, Rivet-Bastide M, Franke C, Lomonaco M, Ricker K, Lehmann-Horn F. Human sodium channel myotonia: Slowed channel inactivation due to substitutions for a glycine within the III-IV linker. J Physiol 1993;470,13-22.

Brain Imaging

Roebling R, Przybylski C, Maier C, Lerche H, Grön G. Retrieval mode-dependent evaluation of the subsequent memory effect of hippocampal encoding, submitted.

Weber YG, Roebling R, Kassubek J, Hoffmann S, Rosenbohm A, Wolf M, Steinbach P, Jurkat-Rott K, Gostomzyk J, Walter H, Reske SN, Lehmann-Horn F, Mottaghy FM, Lerche H. Structural and functional brain abnormalities in myotonic dystrophy type 1 and 2. Neurology, in revision.

Roebling R, Scheerer N, Uttner I, Gruber O, Kraft E, Lerche H. Evaluation of cognition, structural, and functional MRI in juvenile myoclonic epilepsy. Epilepsia 2009 [Epub ahead of print]

Roebling R, Huch K, Kassubek J, Lerche H, Weber Y. Cervical spinal MRI in a patient with a vagus nerve stimulator (VNS). Epilepsy Res. 2009;84:273-5.

Roebling R, Lerche H. Painful seizures associated with a lesion in the midcingulate cortex. J Neurol 2009;256:1012-4.

Stem cells (collaboration with A. Storch, Dresden)

Maisel M, Herr A, Milosevic J, Hermann A, Habisch HJ, Schwarz S, Kirsch M, Antoniadis G, Brenner R, Hallmeyer-Elgner S, Lerche H, Schwarz J, Storch A..Transcription profiling of adult and fetal human neuroprogenitors identifies divergent paths to maintain the neuroprogenitor cell state. Stem cells 2007;25:1231-40.

Hermann A, Maisel M, Liebau S, Gerlach M, Kleger A, Schwarz J, Kim KS, Antoniadis G, Lerche H, Storch A. Mesodermal cell types induce neurogenesis from adult human hippocampal progenitor cells. J Neurochem 2006;98:629-40.

Hermann A, Gastl R, Liebau S, Popa O, Fiedler J, Boehm BO, Lerche H, Schwarz J, Brenner R, Storch A. Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells. J Cell Sci 2004;117:4411-22.

Invited reviews:

Weber YG, Lerche H. Genetics of paroxysmal dyskinesias. Curr Neurol Neurosci Rep 2009;9(3):206-11.

Lang F, Gulbins E, Lerche H, Huber SM, Kempe DS, Föller M. Eryptosis, a window to systemic disease. Cell Physiol Biochem 2008;22:373-80

Jacob M, Weber YG, Lerche H. Benigne familiäre Anfälle des Neugeborenen- und Säuglingsalters. Zeitschr Epil 2008;21:142-8

Weber YG, Lerche H. Genetic mechanisms in idiopathic epilepsies. Dev Med Child Neurology 2008;50:648-654

Maljevic S, Wuttke T, Seebohm G, Lerche H. Role of the KCNQ gene family in ion channel disorders. Cell Science 2008;4:53-73, online Journal

Maljevic S, Wuttke T, Lerche H. Nervous system K_V7 disorders: break down of a subthreshold brake. J Physiol 2008;586:1791-801.

Krämer G, Bergmann A, Elger CE, Lerche H, Löscher W, Luef G, Rosenow F, Schmidt D, Schmitz B, Steinhoff BJ, Stodieck SRG, Trinka E, Werhahn KJ. Stellenwert von Valproat in der Therapie von fokalen Epilepsien bei Erwachsenen. Akt Neurol 2007;34:570-6

Wuttke T, Lerche H. Novel anticonvulsant drugs targeting voltage-dependent ion channels. Exp Opin Invest Drugs 2006;15:1167-77.

Maljevic S, Lerche H. Ion channel dysfunctions in idiopathic epilepsies. Curr Med Lit Neurol 2006;22:33-47.

Lerche H, Weber YG, Jurkat-Rott K, Lehmann-Horn F. Ion channel defects in idiopathic epilepsies. Curr Pharm Des 2005;11:2737-52.

Lerche H, Weber YG, Heils A. Genetik und Pathophysiologie idiopathischer Epilepsien. Nervenheilkunde 2004;23:188-96.

Lerche H, Mitrovic N, Jurkat-Rott K, Lehmann-Horn F. Sodium channelopathies in skeletal muscle and brain. Adv Clin Neurophysiol 2002;54:63-70

Jurkat-Rott K, Lerche H, Lehmann-Horn F. Skeletal muscle channelopathies. J Neurol 2002;249:1493-502.

Lerche H, Jurkat-Rott K, Lehmann-Horn F. Ion channels and epilepsy. Am J Med Gen (Sem Med Gen) 2001;106:146-59.

Lerche H, Mitrovic N, Jurkat-Rott K, Lehmann-Horn F. Ionenkanalerkrankungen: Krankheitsbilder. Dt Ärztebl 2000;97:A-1902-7 (Heft 27).

Lerche H, Mitrovic N, Jurkat-Rott K, Lehmann-Horn F. Ionenkanalerkrankungen - Allgemeine Charakteristika und Pathomechanismen. Dt Ärztebl 2000;97:A-1826-31 (Heft 26).

Jurkat-Rott K, Lerche H, Mitrovic N, Lehmann-Horn F. Ion channelopathies in neurology. J Neurol 1999;246:758-63.

Lerche H, Mitrovic N, Lehmann-Horn F. Ionenkanalerkrankungen in der Neurologie. Fortschr Neurol Psychiat 1997;65:481-8

Lerche H, Jurkat-Rott K, Mitrovic N, Lehmann-Horn F. Neue Erkenntnisse auf dem Gebiet der Myotonien und periodischen Paralysen. EEG-Labor 1997;19/2:55-66

Book chapters:

Lerche H, Maljevic S. Aetiology of idiopathic focal seizures. In: The Educational Kit on Epilepsies Vol 5. Focal Epilesies. Editor: Panayiotopoulos CP, in press.

Cendes F, Lopes-Cendes I, Beck H, Lerche H, Elger CE. Mesial temporal lobe epilepsy. In: ‘Encyclopedia of Molecular Mechanisms of Disease', Lehmann-Horn F and Lerche H, Co-Editors for the Neurosciences, Editor in Chief: Lang F, Springer Verlag, in press.

Köhling R, Lerche H. Lesion-associated partial epilepsies. In: ‘Encyclopedia of Molecular Mechanisms of Disease', Lehmann-Horn F and Lerche H, Co-Editors for the Neurosciences, Editor in Chief: Lang F, Springer Verlag, in press.

Lerche H, Scheffer IE, Berkovic SF. Generalized (genetic) epilepsy with febrile seizures plus, severe myoclonic epilepsy of infancy (Dravet syndrome), intractable childhood epilepsy with generalized tonic clonic seizures and related syndromes. In: ‘Encyclopedia of Molecular Mechanisms of Disease', Lehmann-Horn F and Lerche H, Co-Editors for the Neurosciences, Editor in Chief: Lang F, Springer Verlag, in press.

Lerche H, Marini C, Guerrini R, Zara F. Idiopathic generalized epilepsies. In: ‘Encyclopedia of Molecular Mechanisms of Disease', Lehmann-Horn F and Lerche H, Co-Editors for the Neurosciences, Editor in Chief: Lang F, Springer Verlag, in press.

Lerche H, Maljevic S, Weber YG. Genetics and pathophysiological mechanisms in idiopathic epilepsies. In: Plecko B (Ed). Symposia Proceedings: Metabolic and genetic infantile epilepsies, Int. Symposium ‘Focus on Neuropediatrics' 2005 (Fulda), SPS Publications, Heilbronn, 2006, pp 58-89.

Elger CE, Bauer J, Janzen RWC, Kurthen M, Lerche H, Schmidt D, Stefan H. Epilepsien im Erwachsenenalter. In: Diener HC (Herausgeber für die Kommission Leitlinien der Deutschen Gesellschaft für Neurologie). Leitlinien für Diagnostik und Therapie in der Neurologie, 2. überarbeitete Auflage, Stuttgart, Thieme, 2005.

Kurthen M, Bauer J, Janzen RWC, Lerche H, Schmidt D, Stefan H. Status epilepticus im Erwachsenenalter. In: Diener HC (Herausgeber für die Kommission Leitlinien der Deutschen Gesellschaft für Neurologie). Leitlinien für Diagnostik und Therapie in der Neurologie, 2. überarbeitete Auflage, Stuttgart, Thieme, 2005.

Lerche H, Lehmann-Horn F. Compounds acting on ion channels. In: Neurodegenerative Diseases: Neurobiology, Pathogenesis and Therapeutics. Ed.: Beal F, Lang A, Ludolph AC. Cambridge University Press, 2005, pp141-5.

Homberg V, Lerche H. Therapiebeendigung. In: Die Epilepsien. Ed.: Fröscher W, Vassella F, Hufnagel A. Schattauer Verlag, 2004.

Lehmann-Horn, Lerche H, Jurkat-Rott K. Skeletal muscle channelopathies: myotonias, periodic paralyses and malignant hyperthermia. In: Stålberg E (Ed). Clinical neurophysiology of disorders of muscle and neuromuscular junction, including fatigue. Handbook of Clinical Neurophysiology, Elsevier, 2003, Vol. 2, Chapter 23, pp 457-83.

Elger CE, Bauer J, Janzen RWC, Kurthen M, Lerche H, Schmidt D, Stefan H. Epilepsien im Erwachsenenalter. In: Diener HC (Herausgeber für die Kommission Leitlinien der Deutschen Gesellschaft für Neurologie). Leitlinien für Diagnostik und Therapie in der Neurologie, 1. Auflage, Stuttgart, Thieme, 2002.

Kurthen M, Bauer J, Janzen RWC, Lerche H, Schmidt D, Stefan H. Status epilepticus im Erwachsenenalter. In: Diener HC (Herausgeber für die Kommission Leitlinien der Deutschen Gesellschaft für Neurologie). Leitlinien für Diagnostik und Therapie in der Neurologie, 1. Auflage, Stuttgart, Thieme, 2002.

Lerche H, Mitrovic N, Jurkat-Rott K, Lehmann-Horn F. Nichtdystrophische Myotonien und periodische Paralysen. In: Neurogenetik, 2. Auflage. Ed.: Riess O, Schöls L. Kohlhammer Verlag, 2002, pp 515-23.

Jurkat-Rott K, Lerche H, Lehmann-Horn F. Episodische Ataxien. In: Neurogenetik, 2. Auflage. Ed.: Riess O, Schöls L. Kohlhammer Verlag, 2002, pp 409-14.

Jurkat-Rott K, Lerche H, Lehmann-Horn F. Migräne. In: Neurogenetik, 2. Auflage. Ed.: Riess O, Schöls L. Kohlhammer Verlag, 2002, pp 290-7.

Heils A, Lerche H. Epilepsien. In: Neurogenetik, 2. Auflage. Ed.: Riess O, Schöls L. Kohlhammer Verlag, 2002, pp 253-71.

Mitrovic N, Lerche H. Neuromuskuläre Übertragungsstörungen. In: Neurologische Therapie, 3. Auflage. Ed.: Lehmann-Horn F, Ludolph AC. Urban & Fischer, 2001, pp 294-305

Lerche H, Mitrovic N. Myopathien. In: Neurologische Therapie, 3. Auflage. Ed.: Lehmann-Horn F, Ludolph AC. Urban & Fischer, 2001, pp 306-26.

Mitrovic N, Lerche H. Sodium and calcium channelopathies of sarcolemma: periodic paralyses, paramyotonia congenita and potassium-aggravated myotonia. In: Channelopathies - Common Mechanisms in Aura, Arrhythmia and Alkalosis. Ed.: Lehmann-Horn F, Jurkat-Rott K. Elsevier-Science, 2000, pp 3-32.

Jurkat-Rott K, Lerche H, Lehmann-Horn F. Migräne und episodische Ataxien. In: Neurogenetik, 1. Auflage. Ed.: Riess O, Schöls L. Springer Verlag, 1998, pp 115-9.

Lerche H, Mitrovic N, Jurkat-Rott K, Lehmann-Horn F. Nichtdystrophische Myotonien und periodische Paralysen. In: Neurogenetik, 1. Auflage. Ed.: Riess O, Schöls L. Springer Verlag, 1998, pp 353-62.

Lerche H, Lehmann-Horn F. Krankheitsbilder mit dem Leitsymptom der generalisierten Muskeltonussteigerung. In: Neurologische Syndrome in der Intensivmedizin - Differential-diagnose und Akuttherapie, 2. Auflage. Ed.: Stöhr M, Brandt Th, Einhäupl KM. Kohlhammer Verlag, 1998, pp 264-77.