in the Functional Neurogenomics Laboratory of the Hertie-Institute for Clinical Brain Research on
Mitochondrial dynamics in neurodegeneration in Parkinson's disease
Our main focus is to analyze mitochondrial function and dynamics in genetic paradigms of Parkinson's disease.
We defined a novel role of Omi/HtrA2 (PARK13) in the pathogenesis of PD that underscored a critical relation between mitochondrial dysfunction and neurodegeneration. Based on cellular and transgenic animal models the project aims at the definition of molecular signaling cascades involved in mitochondrial morphology and function. The project is funded by the German Genome Research Network and integrated into national and international interdisciplinary research efforts.
This work will involve a broad range of techniques including standard techniques in molecular biology, FACS assays as well as fluorescence and confocal microscopy including cellular in vivo imaging. The candidate will be responsible for applying and developing technologies and methods for functional assays on mitochondrial dynamics in different cellular models, assays for chaperone function, quantitation of autophagy and pharmacological modulation of mitochondrial dysfunction.
Applicants should have a good scientific background in a relevant discipline (i.e. biology, biochemistry) and should be experienced in molecular and cellular neurobiology. The ideal candidate will be skilled in the utilisation of primary cell culture and animal models. Candidates are expected to be highly motivated and willing to develop their conceptual skills. The successful candidate is supposed to participate in the Graduate School of Cellular & Molecular Neuroscience of the University of Tübingen.
Starting from February 2010. Remuneration is TV-L (E13/2), three years with option to extend.
E-Mail or post your CV with photo, copies of certificates, publications and 2-3 references to the office of
Prof. Dr. Rejko Krüger (rejko.krueger(at)uni-tuebingen.de)
Functional Neurogenomics Laboratory,
Hertie-Institut for Clinical Brain Research, Otfried-Müller-Str. 27, 72076 Tübingen, Germany