Publications

Original Articles

Imam, S. Z., Zhou, Q., Yamamoto, A., Valente, A. J., Ali, S. F., Bains, M., Roberts, J. L., Kahle, P. J., Clark, R. A., and Li, S. (2011) Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's disease. J. Neurosci. 31, 157-163

Ünal-Çevik, I., Gürsoy-Özdemir, Y., Yemişçi, M., Lüle, S., Gurer, G., Can A., Müller, V., Kahle, P. J., and Dalkara, T. (2011) Alpha-synuclein aggregation induced by brief ischemia negatively impacts neuronal survival in vivo: a study in [A30P]alpha-synuclein transgenic mouse. J. Cereb. Blood Flow Metab. 31, 913-923

Geisler, S., Holmström, K. M., Treis, A., Skujat, D., Weber, S. S., Fiesel, F. C., Kahle, P. J., and Springer, W. (2010) The PINK1/parkin-mediated mitophagy is compromised by PD-associated mutations. Autophagy 6, 871-878

Voigt, A., Herholz, D., Fiesel, F. C., Kaur, K., Müller, D., Karsten, P., Weber, S. S., Kahle, P. J., Marquardt, T., and Schulz, J. B. (2010) TDP-43-mediated neuron loss in vivo requires RNA-binding activity. PLoS One 5, e12247

Siebert, H., Kahle, P. J.,Kramer, M. L., Isik, T., Schlüter, O. M., Schulz-Schaeffer, W. J., and Brück, W. (2010) Overexpression of α-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain. J. Neurochem. 114, 1007-1018

Cornejo Castro, E. M., Waak, J.,Weber, S. S., Fiesel, F. C., Oberhettinger, P., Schütz, M., Autenrieth, I. B., Springer, W., and Kahle, P. J. (2010) Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans. J. Neural Transm. 117, 599-604

Pham, T. T., Giesert, F., Röthig, A., Floss, T., Kallnik, M., Weindl, K., Hölter, S. M., Ahting, U., Prokisch, H., Becker, L., Klopstock, T., Beyer, K., Görner, K., Kahle, P. J., Vogt-Weisenhorn, D. M., and Wurst, W. (2010) DJ-1 deficient mice show less TH positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments. Genes Brain Behav. 9, 305-317

Carballo-Carbajal, I., Weber-Endress, S., Rovelli, G., Chan, D., Wolozin, B., Klein, C. L., Patenge, N., Gasser, T., and Kahle, P. J. (2010) Leucine-rich repreat kinase 2 induces α-synuclein expression via the extracellular signal-regulated kinase pathway. Cell. Signal. 22, 821-827

Kieper, N., Holmström, K. M., Ciceri, D., Fiesel, F. C., Wolburg, H., Martins, L. M., Kahle, P. J., and Krüger, R. (2010) Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the fusion protein OPA1. Exp. Cell Res. 316, 1213-1224

Krebiehl, G., Ruckerbauer, S., Burbulla, L. F., Kieper, N., Maurer, B., Waak, J., Wolburg, H., Gizatullina, Z., Gellerich, F. N., Woitalla, D., Riess, O., Kahle, P. J., Proikas-Cezanne, T., and Krüger, R. (2010) Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS ONE 5, e9367

Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., and Springer, W. (2010). PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat. Cell Biol. 12, 119-131

Mbefo, M. K., Paleologou, K. E., Boucharaba, A., Oueslati, A., Schell, H., Fournier, M., Olschewski, D., Yin, G., Zweckstetter, M., Masliah, E., Kahle, P. J., Hirling, H., and Lashuel, H. A. (2010) Phosphorylation of synucleins by members of the polo-like kinase family. J. Biol. Chem. 285, 2807-2822

Fiesel, F. C., Voigt, A., Weber, S. S., Van den Heute, C., Waldenmaier, A., Görner, K., Walter, M., Anderson, M. L., Kern, J. V., Rasse, T. M., Schmidt, T., Springer, W., Kirchner, R., Bonin, M., Neumann, M., Baekelandt, V., Alunni-Fabbroni, M., Schulz, J. B., and Kahle, P. J. (2010) Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6. EMBO J. 29, 209-221

Wilms, H., Rosenstiel, P., Romero-Ramos, M., Arlt, A., Schäfer, H., Seegert, D., Kahle, P. J., Odoy, S., Claasen, J. H., Holzknecht, C., Brandenburg, L. O., Deuschl, G., Schreiber, S., Kirik, D., and Lucius, R. (2009) Suppression of MAP kinases inhibits microglial activation and attenuate neuronal cell death induced by a-synuclein protofibrils. Int. J. Immunopathol. Pharmacol. 22, 897-909

Klein, C. L., Rovelli, G., Springer, W., Schall, C., Gasser, T., and Kahle, P. J. (2009) Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment. J. Neurochem. 111, 703-715

Fournier, M., Vitte, J., Garrigue, J., Langui, D., Dullin, J.-P., Saurini, F., Hanoun, N., Perez-Diaz, F., Cornilleau, F., Joubert, C., Ardila-Osorio, H., Traver, S., Duchateau, R., Goujet-Zalc, C., Paleologou, K., Lashuel, H. A., Haass, C., Duyckaerts, C., Cohen-Salmon, C., Kahle, P. J., Hamon, M., Brice, A., and Corti, O. (2009) Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. PLoS ONE 4, e6629

Waak, J., Weber, S. S., Waldenmaier, A., Görner, K., Alunni-Fabbroni, M., Schell, H., Vogt-Weisenhorn, D., Pham, T.-T., Reumers, V., Baekelandt, V., Wurst, W., and Kahle, P. J. (2009) Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1. FASEB J. 23, 2478-2489

Schell, H., Hasegawa, T., Neumann, M., and Kahle, P. J. (2009) Nuclear and neuritic distribution of serine-129 phosphorylated a-synuclein in transgenic mice. Neuroscience 160, 796-804

Waak, J., Weber, S. S., Görner, K., Schall, C., Ichijo, H., Stehle, T., and Kahle, P. J. (2009) Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase-1. J. Biol. Chem. 284, 14245-14257

Koch, A., Lehmann-Horn, K., Dächsel, J. C., Gasser, T., Kahle, P. J., and Lücking, C. B. (2009) Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells. Parkinsonism Relat. Disord. 15, 220-225

Hasegawa, T., Treis, A., Patenge, N., Fiesel, F. C., Springer, W., and Kahle, P. J. (2008). Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways. J. Neurochem. 105, 1700-1715

Stefanova, N., Reindl, M., Neumann, M., Kahle, P. J., Poewe, W., and Wenning, G. K. (2007) Microglial activation mediates neurodegeneration related to oligodendroglial α-synucleinopathy: Implications for multiple system atrophy. Mov Disord. 22, 2196-2203

Exner, N., Treske, B., Paquet, D., Holmström, K., Schiesling, C., Gispert, S., Carballo-Carbajal, I., Berg, D., Gasser, T., Krüger, R., Winklhofer, K. F., Vogel, F., Reichert, A. S., Auburger, G., Kahle, P. J., Schmid, B., and Haass, C. (2007) Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J. Neurosci. 27, 12413-12418

Görner, K., Holtorf, E., Waak, J., Pham, T.-T., Vogt-Weisenhorn, D. M., Wurst, W., Haass, C., and Kahle, P. J. (2007) Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival-promoting activity of DJ-1. J. Biol. Chem. 282, 13680-13691

Freichel, C., Neumann, M., Ballard, T., Müller, V., Woolley, M., Ozmen, L., Borroni, E., Kretzschmar, H. A., Haass, C., Spooren, W., and Kahle, P. J. (2007) Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice. Neurobiol. Aging 28, 1421-1435

Gerard, M., Debyser, Z., Desender, L., Kahle, P. J., Baert, J., Baekelandt, V., and Engelborghs, Y. (2006) The aggregation of α-synuclein is stimulated by FK506 binding proteins as shown by Fluorescence Correlation Spectroscopy. FASEB J. 20, 524-526

Springer, W., Hoppe, T., Schmidt, E., Baumeister, R. (2005) A Caenorhabditis elegans parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress. Hum. Mol. Genet. 14, 3407-3423

Giese, A., Bader, B., Bieschke, J., Schaffar, G., Odoy, S., Kahle, P. J., Haass, C., and Kretzschmar, H. A. (2005) Single particle detection and characterization of synuclein co-aggregation. Biochem. Biophys. Res. Commun. 333, 1202-1210

Dächsel, J. C., Lücking, C. B., Deeg, S., Schultz, E., Lalowski, M., Casademunt, E., Corti, O., Hampe, C., Patenge, N., Vaupel, K., Yamamoto, A., Dichgans, M., Brice, A., Wanker, E. E., Kahle, P. J., and Gasser, T. (2005) Parkin interacts with the proteasome subunit a4. FEBS Lett. 579, 3913-3919

Frasier, M., Walzer, M., McCarthy, L., Magnuson, D., Lee, J. M., Haass, C., Kahle, P. J., and Wolozin, B. (2005) Tau phosphorylation increases in symptomatic mice overexpressing [A30P]α-synuclein. Exp. Neurol. 192, 274-287

Stefanova, N., Reindl, M., Neumann, M., Haass, C., Poewe, W., Kahle, P. J., and Wenning, G. K. (2005) Oxidative stress in transgenic mice with oligodendroglial α-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy. Am. J. Pathol. 166, 869-876

Yamamoto, A., Imai, Y., Takahashi, R., Kahle, P. J., and Haass, C. (2005) Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity. J. Biol. Chem. 280, 3390-3399

Neumann, M., Müller, V., Kretzschmar, H. A., Haass, C., and Kahle, P. J. (2004) Regional distribution of proteinase K-resistant α-synuclein correlates with Lewy body disease stage. J. Neuropathol. Exp. Neurol. 63, 1225–1235

Hoppe, T., Cassata, G., Barral, J. M., Springer, W., Hutagalung, A. H., Epstein, H. F., and Baumeister, R. (2004) Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans. Cell 118, 337-349

Nuscher, B., Kamp, F., Mehnert, T., Odoy, S., Haass, C., Kahle, P. J., and Beyer, K. (2004) α-Synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study. J. Biol. Chem. 279, 21966-21975

Neumann, M., Müller, V., Görner, K., Kretzschmar, H. A., Haass, C., and Kahle, P. J. (2004) Pathological properties of the Parkinson’s disease-associated protein DJ-1 in α-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick’s disease. Acta Neuropathol. 107, 489-496

Görner, K., Holtorf, E., Odoy, S., Nuscher, B., Yamamoto, A., Regula, J. T., Beyer, K., Haass, C., Kahle, P. J. (2004) Differential effects of Parkinson’s disease-associated mutations on stability and folding of DJ-1. J. Biol. Chem. 279, 6943-6951

Neumann, M., Kahle, P. J., Giasson, B. I., Ozmen, L., Borroni, E., Spooren, W., Müller, V., Odoy, S., Fujiwara, H., Hasegawa, M., Iwatsubo, T., Trojanowski, J. Q., Kretzschmar, H. A., and Haass, C. (2002) Misfolded proteinase K-resistant and hyperphosphorylated α-synuclein in aged transgenic mice and in Lewy body disease patients. J. Clin. Invest. 110, 1429-1439

Kahle, P. J., Neumann, M., Ozmen, L., Müller, V., Jacobsen, H., Spooren, W., Fuss, B., Mallon, B., Macklin, W. B., Fujiwara, H., Hasegawa, M., Iwatsubo, T., Kretzschmar, H. A., and Haass, C. (2002) Hyperphosphorylation and insolubility of α-synuclein in transgenic mouse oligodendrocytes. EMBO Rep. 3, 583-588

Kahle, P. J., Neumann, M., Ozmen, L., Müller, V., Odoy, S., Okamoto, N., Jacobsen, H., Iwatsubo, T., Trojanowski, J. Q., Takahashi, H., Wakabayashi, K., Bogdanovic, N., Riederer, P., Kretzschmar, H. A., and Haass, C. (2001) Selective insolubility of α-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am. J. Pathol. 159, 2215-2225

Rathke-Hartlieb, S., Kahle, P. J., Neumann, M., Ozmen, L., Haid, S., Okochi, M., Haass, C., Schulz, J. B. (2001) Sensitivity to MPTP is not increased in Parkinson’s disease-associated mutant α-synuclein transgenic mice. J. Neurochem. 77, 1181-1184

Wirths, O., Weickert, S., Majtenyi, K., Havas, L., Okochi, M., Kahle, P. J., Haass, C., Multhaup, G., Beyreuther, K., and Bayer, T. A. (2000) Lewy body variant of Alzheimer’s disease: α-synuclein in dystrophic neurites of Ab plaques. NeuroReport 11, 3737-3741

Kahle, P. J., Neumann, M., Ozmen, L., Müller, V., Jacobsen, H., Schindzielorz, A., Okochi, M., Leimer, U., van der Putten, H., Probst, A., Kremmer, E., Kretzschmar, H. A., and Haass, C. (2000) Subcellular localization of wild-type and Parkinson’s disease-associated mutant α-synuclein in human and transgenic mouse brain. J. Neurosci. 20, 6365-6373

Hampel, H., Bürger, K., Teipel, S. J., Padberg, F., Kohnken, R., Zinkowski, R., Kahle, P., Rapoport, S. I., Sunderland, T., Davies, P., and Möller, H.-J. (2000) CSF total and phosphorylated tau in Alzheimer’s disease: Perspectives for early detection, differential diagnosis and mapping of disease progression. J. Lab. Med. 24, 559

Kahle, P. J., Jakowec, M., Teipel, S. J., Hampel, H., Petzinger, G. M., Di Monte, D. A., Silverberg, G. D., Möller, H.-J., Yesavage, J. A., Tinklenberg, J. R., Shooter, E. M., and Murphy, G. M., Jr. (2000) Combined assessment of tau and neuronal thread protein in Alzheimer disease cerebrospinal fluid. Neurology 54, 1498-1504

Okochi, M., Walter, J., Koyama, A., Nakajo, S., Baba, M., Iwatsubo, T., Meijer, L., Kahle, P. J., and Haass, C. (2000) Constitutive phosphorylation of the Parkinson’s disease associated α-synuclein. J. Biol. Chem. 275, 390-397

Kahle, P. J., Shooter, E. M., Johnson, R. M., and Verity, A. N. (1998) Phosphatidylcholine-specific phospholipase inhibitor D609 differentially affects MAP kinases and immediate-early genes in PC12 cells. Cell. Signal. 10, 321-330

Horstmann, S., Kahle, P. J., and Borasio, G. D. (1998) Inhibitors of p38 mitogen-activated protein kinase promote neuronal survival in vitro. J. Neurosci. Res. 52, 483-490

Maas, J. W., Jr., Horstmann, S., Borasio, G. D., Anneser, J. M. H., Shooter, E. M., and Kahle, P. J. (1998) Apoptosis of central and peripheral neurons can be prevented with cyclin-dependent kinase / mitogen-activated protein kinase inhibitors. J. Neurochem. 70, 1401-1410

Krüttgen, A., Heymach, J. V., Jr., Kahle, P. J., and Shooter, E. M. (1997) The role of the nerve growth factor carboxyl terminus in receptor binding and conformational stability. J. Biol. Chem. 272, 29222-29228

Markus, M. A., Kahle, P. J., Winkler, A., Horstmann, S., Anneser, J. M. H., and Borasio, G. D. (1997) Survival-promoting activity of inhibitors of cyclin-dependent kinases on primary neurons correlates with inhibition of c-Jun kinase-1. Neurobiol. Dis. 4, 122-133

Kahle, P., Barker, P. A., Shooter, E. M., and Hertel, C. (1994) p75 nerve growth factor receptor modulates p140trkA kinase activity, but not ligand internalization, in PC12 cells. J. Neurosci. Res. 38, 599-606

Kahle, P., Mangold, M., Kuwahara, T., Schubenel, R., and Hertel, C. (1994) Protein kinase inhibitor H-7 differentially affects early and delayed nerve growth factor responses in PC12 cells. J. Neurochem. 62, 479-488

Kahle, P., Burton, L. E., Schmelzer, C. H., and Hertel, C. (1992) The amino terminus of nerve growth factor is involved in the interaction with the receptor tyrosine kinase p140trkA. J. Biol. Chem. 267, 22707-22710

Kahle, P., and Hertel, C. (1992) Nerve growth factor (NGF) receptor on rat glial cell lines. Evidence for NGF internalization via p75NGFR. J. Biol. Chem. 267, 13917-13923

Reviews and Commentaries

Fiesel, F. C., and Kahle, P. J. (2011) TDP-43 and FUS/TLS: role in the pathophysiology of neurodegeneration processes. FEBS J. 278, 3550-3568

Springer, W., and Kahle, P. J. (2011) Regulation of PINK1-parkin-mediated mitophagy. Autophagy 7, 266-278

Kahle, P. J., Waak, J., and Gasser, T. (2009) DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. Free Radic. Biol. Med. 47, 1354-1361

Kahle, P. J. (2008) α-synucleinopathy models and human neuropathology: similarities and differences. Acta Neuropathol. 115, 87-95

Springer, W., and Kahle, P. J. (2006) Mechanisms and models of α-synuclein-related neurodegeneration. Curr. Neurol. Neurosci. Rep. 6, 432-436

Fillon, G., and Kahle, P. J. (2005) α-Synuclein transgenic mice: relevance to multiple system atrophy. Mov. Disord. 20, S64-S66

Kahle, P. J., and Haass, C. (2004) How does parkin ligate ubiquitin to Parkinson’s disease? EMBO Rep. 5, 681-685 Kahle, P. J., and De Strooper, B. (2003) Attack on amyloid. EMBO Rep. 4, 747-751

Kahle, P. J., Haass, C., Kretzschmar, H. A., and Neumann, M. (2002) Structure / function of α-synuclein in health and disease: rational development of animal models for Parkinson’s and related diseases. J. Neurochem. 82, 449-457

Haass, C., and Kahle, P. J. (2001) Parkin and its substrates. Science 293, 224-225 Kahle, P. J., and Haass, C. (2001) The emerging utility of animal models of chronic neurodegenerative diseases. Emerging Therapeutic Targets 5, 125-132

Kahle, P. J., Neumann, M., Ozmen, L., and Haass, C. (2000) Physiology and pathophysiology of α-synuclein: cell culture and transgenic animal models based on a Parkinson’s disease-associated protein. Ann. NY Acad. Sci. 920, 33-41

Kahle, P. J., Leimer, U., and Haass, C. (2000) Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism? Trends Biochem. Sci. 25, 524-527

Haass, C., and Kahle, P. J. (2000) Parkinson’s pathology in a fly. Nature 404, 341-343 Waggie, K. S., Kahle, P. J., and Tolwani, R. J. (1999) Neurons and mechanisms of neuronal death in neurodegenerative diseases: a brief review. Lab. Anim. Sci. 49, 358-362