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Publikationen
2008
Jung C, Stoeckle C, Wiesmüller K-H, Laub R, Emmrich F, Jung G, Melms A. Complementary strategies to elucidate T helper cell epitopes in myasthenia gravis. J Neuroimmunol. 2008 Sep 15;201-202:41-9
Stoeckle C, Gleske A-K. Immunotherapy: from basic research to clinical applications. Cancer Immunol Immunother. 2008; Jun 27. [Epub ahead of print]
Stoeckle C, Sommandas V, Adamopoulou E, Belisle K, Schiekofer S, Melms A, Weber E, Driessen C, Boehm BO, Tolosa E, Burster T. Cathepsin G is differentially expressed in primary human antigen-presenting cells. Cell Immunol. 2008 Nov 24. [Epub ahead of print]
2007
Feger U, Tolosa E, Huang YH, Waschbisch A, Biedermann T, Melms A, Wiendl H. HLA-G expression defines a novel regulatory T cell subset present in human peripheral blood and sites of inflammation. Blood. 2007; 110:568-577
Lange C, Durr M, Doster H, Melms A, Bischof F. Dendritic cell-regulatory T-cell
inter-actions control self-directed immunity. Immunol Cell Biol. 2007; [Epub ahead of
print]
Burster T, Beck A, Poeschel S, Øren A, Baechle D, Reich M, Roetzschke O, Falk K, Boehm BO, Youssef S, Kalbacher H, Overkleeft H, Tolosa E, Driessen C. Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro. Immunology. 2007 May;121(1):82-93
Rosenkranz D, Weyer S, Tolosa E, Gaenslen A, Berg D, Leyhe T, Gasser T, Stoltze L. Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration. J Neuroimmunol. 2007 Aug;188(1-2):117-27
Maetzler W, Berg D, Schalamberidze N, Melms A, Schott K, Mueller JC, Liaw L, Gasser T, Nitsch C. Osteopontin is elevated in Parkinson's disease and its absence leads to reduced neurodegeneration in the MPTP model. Neurobiol Dis. 2007; 25:473-482
Adamopoulou E, Diekmann J, Tolosa E, Kuntz G, Einsele H, Rammensee HG, Topp MS. Human CD4+ T cells displaying viral epitopes elicit a functional virus-specific memory CD8+ T cell response. J Immunol. 2007 May 1;178(9):5465-72.
Feger U, Luther C, Schreiner B, Poeschel S, Melms A, Tolosa E, Wiendl H. The frequency of CD4+CD25bright T regulatory cells is increased in the CSF but not in the blood of MS patients. Clin Immunol 2007;147:412-418
Wiendl H, Kieseier BC, Weissert R, Mylius HA, Pichlmeier U, Hartung HP, Melms A, Kuker W, Weller M. Treatment of active secondary progressive multiple sclerosis with treosulfan. J Neurol. 2007; 254:884-889.
Viken MK, Dahlen Sollid H, Joner G, Dahl-Jørgensen K, Rønningen KS, Undlien DE, Flato B, Selvaag AM, Forre O, Kvien TK, Thorsby E, Melms A, Tolosa E, Benedicte A. Lie. The cathepsin L2 (CTSL2) gene, important for antigen presentation in thymus, shows association with type 1 diabetes and myasthenia gravis. Human Immunol 2007; 68:748-755
2006
Melms A, Luther C, Stoeckle C, Poeschel S, Schroth P, Varga M, Winehold W, Tolosa E. Thymus and myasthenia gravis: antigen processing in the human thymus and the consequences for the generation of autoreactive T cells. Acta Neurol Scand Suppl. 2006;183:12-3.
Drumea-Mirancea M, Wessels JT, Müller CA, Eble JA, Tolosa E, Koch M, Reinhardt DT, Sixt M, Sorokin L, Stierhof Y-D, Schwarz H, Klein G. Characterization of a laminin-5 containing conduit system in the human thymus. A potential transport system for small molecules. J Cell Sci. 2006;119:1396-405
Schreiner B, Voss J, Wischhusen J, Dombrowski Y, Steinle A, Lochmuller H, Dalakas M, Melms A, Wiendl H. Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release, and up-regulation of NKG2D-ligands. FASEB J. 2006;20(1):118-20.
2005
Burster T, Beck A, Tolosa E, Schnorrer P, Weissert R, Reich M, Krauss M, Kalbacher H, Häring HU, Weber E, Overkleeft H, Driessen C. Differential processing of autoantigens in human monocyte-derived and peripheral blood dendritic cells. J Immunol 2005;175 5940-5949.
Kotter I, Gunaydin I, Batra M, Vonthein R, Stubiger N, Fierlbeck G, Melms A. CNS involvement occurs more frequently in patients with Behcet's disease under cyclosporin A (CSA) than under other medications-results of a retrospective analysis of 117 cases. Clin Rheumatol. 2005:1-5.
Luther C, Poeschel S, Varga M, Melms A, Tolosa E. Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma. J Neuroimmunol 2005; 164:124-128
Luther C, Wienhold W, Oehlmann R, Heinemann MK, Melms A, Tolosa E. Alternatively spliced transcripts of the human thymus-specific serine protease are differentially expressed in human thymus. Genes Immun. 2005;6:1-7
Magnus T, Schreiner B, Korn T, Jack C, Guo H, Antel J, Ifergan I, Chen L, Bischof F, Bar-Or A, Wiendl H. Microglial expression of the B7-family member B7H1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS. J Neurosci. 2005;25(10):2537-46
Steinbach JP, Melms A, Skalej M, Dichgans J. Delayed resolution of white matter changes following therapy of B. Burgdorferi-associated inflammatory encephalopathy. Neurology. 2005;64(4):758-9
2004
Bischof F, Bins A, Durr M, Zevering Y, Melms A, Kruisbeek AM. A structurally available encephalitogenic epitope of myelin oligodendrocyte glycoprotein specifically induces a diversified pathogenic autoimmune response. J Immunol. 2004;173:600-606.
de Graaf KL, Barth S, Herrmann MM, Storch MK, Otto C, Olsson T, Melms A, Jung G, Wiesmuller KH, Weissert R. MHC class II isotype- and allele-specific attenuation of experimental autoimmune encephalomyelitis. J Immunol. 2004;173:2792-2802.
Bischof F, Hofmann M, Schumacher TN, Vyth-Dreese FA, Weissert R, Schild H, Kruisbeek AM, Melms A. Analysis of autoreactive CD4 T cells in experimental autoimmune encephalomyelitis after primary and secondary challenge using MHC class II tetramers. J Immunol. 2004;172:2878-2884.
Stöckle C, Burster T, Gnau V, Driessen C, Kalbacher H, Melms A, Tolosa E. Processing of MBP by human thymic and peripheral antigen presenting cells. Is processing regulated in patients with multiple sclerosis? In: Monduzzi, ed. Immunology 2004. Vol. 3. Bologna: Medimond; 2004:285-291.
Dornmair K, Schneider CK, Malotka J, Dechant G, Wiendl H, Hohlfeld R. Antigen recognition properties of a Vgamma1.3Vdelta2-T-cell receptor from a rare variant of polymyositis. J Neuroimmunol. 2004;152:168-175.
Bischof F, Nagele T, Wanders RJ, Trefz FK, Melms A. 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in an adult with leukoencephalopathy. Ann Neurol. 2004;56:727-730.
Gaertner S, de Graaf KL, Wienhold W, Wiesmuller KH, Melms A, Weissert R. Lack of pathogenicity of immunodominant T and B cell determinants of the nicotinic acetylcholine receptor epsilon-chain. J Neuroimmunol. 2004;152:44-56.
Herrlinger U, Wiendl H, Renninger M, Forschler H, Dichgans J, Weller M. Vascular endothelial growth factor (VEGF) in leptomeningeal metastasis: diagnostic and prognostic value. Br J Cancer. 2004;91:219-224.
Korn-Lubetzki I, Bien CG, Bauer J, Gomori M, Wiendl H, Trajo L, Ovadia H, Wilken B, Hans VH, Elger CE, Hurvitz H, Steiner I. Rasmussen encephalitis with active inflammation and delayed seizures onset. Neurology. 2004;62:984-986.
Schreiner B, Mitsdoerffer M, Kieseier BC, Chen L, Hartung HP, Weller M, Wiendl H. Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis. J Neuroimmunol. 2004;155:172-182.
Wiendl H, Lehmann HC, Hohlfeld R, Hartung HP, Kieseier BC. Multiple Sklerose: potenzielle Therapieansatze und Update laufender Studien. Nervenarzt. 2004;75:536-552.
Bruno R, Sabater L, Tolosa E, Sospedra M, Ferrer-Francesch X, Coll J, Foz M, Melms A, Pujol-Borrell R. Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymus. J Neuroimmunol. 2004;149:147-159.
Burster T, Beck A, Tolosa E, Marin-Esteban V, Rotzschke O, Falk K, Lautwein A, Reich M, Brandenburg J, Schwarz G, Wiendl H, Melms A, Lehmann R, Stevanovic S, Kalbacher H, Driessen C. Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes. J Immunol. 2004;172:5495-5503.
2003
Tolosa, E., Li, W., Yasuda, Y., Wienhold, W., Denzin, L.K., Lautwein, A., Driessen, C., Schnorrer, P., Weber, E., Stevanovic, S., Kurek, R., Melms, A. & Bromme, D. Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis. J Clin Invest 112, 517-26 (2003).
Wintterle, S., Schreiner, B., Mitsdoerffer, M., Schneider, D., Chen, L., Meyermann, R., Weller, M. & Wiendl, H. Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis. Cancer Res 63, 7462-7 (2003).
Wiendl, H., Mitsdoerffer, M., Hofmeister, V., Wischhusen, J., Weiss, E.H., Dichgans, J., Lochmuller, H., Hohlfeld, R., Melms, A. & Weller, M. The non-classical MHC molecule HLA-G protects human muscle cells from immune-mediated lysis: implications for myoblast transplantation and gene therapy. Brain 126, 176-85 (2003).
Wiendl, H. & Kieseier, B.C. Disease-modifying therapies in multiple sclerosis: an update on recent and ongoing trials and future strategies. Expert Opin Investig Drugs 12, 689-712 (2003).
Wiendl, H., Mitsdoerffer, M., Schneider, D., Melms, A., Lochmuller, H., Hohlfeld, R. & Weller, M. Muscle fibres and cultured muscle cells express the B7.1/2-related inducible co-stimulatory molecule, ICOSL: implications for the pathogenesis of inflammatory myopathies. Brain 126, 1026-35 (2003).
Wiendl, H., Lautwein, A., Mitsdorffer, M., Krause, S., Erfurth, S., Wienhold, W., Morgalla, M., Weber, E., Overkleeft, H.S., Lochmuller, H., Melms, A., Tolosa, E. & Driessen, C. Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies. J Neuroimmunol 138, 132-43 (2003).
Wiendl, H., Neuhaus, O., Mehling, M., Wintterle, S., Schreiner, B., Mitsdoerffer, M., Wienhold, W., Weissert, R., Wessels, J., Hartung, H.P., Weller, M., Tolosa, E. & Melms, A. The CD28 related molecule ICOS: T cell modulation in the presence and absence of B7.1/2 and regulational expression in multiple sclerosis. J Neuroimmunol 140, 177-87 (2003).
Wiendl, H., Mitsdoerffer, M., Schneider, D., Chen, L., Lochmuller, H., Melms, A. & Weller, M. Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies. Faseb J 17, 1892-4 (2003).
Wiendl, H., Feiden, W., Scherieble, H., Renz, T., Dichgans, J. & Weller, M. March 2003: a 41 -year-old female with a solitary lesion in the liver. Brain Pathol 13, 421-3 (2003).
Wiendl, H., Mitsdoerffer, M. & Weller, M. Express and protect yourself: the potential role of HLA-G on muscle cells and in inflammatory myopathies. Hum Immunol 64, 1050-6 (2003).
Wiendl, H., Mitsdoerffer, M. & Weller, M. Hide-and-seek in the brain: a role for HLA-G mediating immune privilege for glioma cells. Semin Cancer Biol 13, 343-51 (2003).
Weissert, R., Wiendl, H., Pfrommer, H., Storch, M.K., Schreiner, B., Barth, S., Seifert, T., Melms, A., Dichgans, J. & Weller, M. Action of treosulfan in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis and human lymphocytes. J Neuroimmunol 144, 28-37 (2003).
Schreiner, B., Wischhusen, J., Mitsdoerffer, M., Schneider, D., Bornemann, A., Melms, A., Tolosa, E., Weller, M. & Wiendl, H. Expression of the B7-related molecule ICOSL by human glioma cells in vitro and in vivo. Glia 44, 296-301 (2003).
Meuth, S.G., Budde, T., Duyar, H., Landgraf, P., Broicher, T., Elbs, M., Brock, R., Weller, M., Weissert, R. & Wiendl, H. Modulation of neuronal activity by the endogenous pentapeptide QYNAD. Eur J Neurosci 18, 2697-706 (2003).
2002
Wiendl, H., Mitsdoerffer, M., Hofmeister, V., Wischhusen, J., Bornemann, A., Meyermann, R., Weiss, E.H., Melms, A. & Weller, M. A functional role of HLA-G expression in human gliomas: an alternative strategy of immune escape. J Immunol 168, 4772-80 (2002).
Wiendl, H., Malotka, J., Holzwarth, B., Weltzien, H.U., Wekerle, H., Hohlfeld, R. & Dornmair, K. An autoreactive gamma delta TCR derived from a polymyositis lesion. J Immunol 169, 515-21 (2002).
Wiendl, H. & Hohlfeld, R. Therapeutic approaches in multiple sclerosis: lessons from failed and interrupted treatment trials. BioDrugs 16, 183-200 (2002).
Weissert, R., Kuhle, J., de Graaf, K.L., Wienhold, W., Herrmann, M.M., Muller, C., Forsthuber, T.G., Wiesmuller, K.H. & Melms, A. High immunogenicity of intracellular myelin oligodendrocyte glycoprotein epitopes. J Immunol 169, 548-56 (2002).
Waltereit, R., Kuker, W., Jurgens, S., Weller, M., Dichgans, J. & Wiendl, H. Acute transverse myelitis associated with coxiella burnetii infection. J Neurol 249, 1459-61 (2002).
Bien, C.G., Bauer, J., Deckwerth, T.L., Wiendl, H., Deckert, M., Wiestler, O.D., Schramm, J., Elger, C.E. & Lassmann, H. Destruction of neurons by cytotoxic T cells: a new pathogenic mechanism in Rasmussen's encephalitis. Ann Neurol 51, 311-8 (2002).
Bien, C.G., Elger, C.E. & Wiendl, H. Advances in pathogenic concepts and therapeutic agents in Rasmussen's encephalitis. Expert Opin Investig Drugs 11, 981-9 (2002).
2001
Hoch, W., McConville, J., Helms, S., Newsom-Davis, J., Melms, A. & Vincent, A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 7, 365-8 (2001).
Wiendl, H., Bien, C.G., Bernasconi, P., Fleckenstein, B., Elger, C.E., Dichgans, J., Mantegazza, R. & Melms, A. GluR3 antibodies: prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis. Neurology 57, 1511-4 (2001).
Mader, I., Seeger, U., Weissert, R., Klose, U., Naegele, T., Melms, A. & Grodd, W. Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis. Brain 124, 953-61 (2001).
Kalbus, M., Fleckenstein, B.T., Offenhausser, M., Bluggel, M., Melms, A., Meyer, H.E., Rammensee, H.G., Martin, R., Jung, G. & Sommer, N. Ligand motif of the autoimmune disease-associated mouse MHC class II molecule H2-A(s). Eur J Immunol 31, 551-62 (2001).
Hohlfeld, R. & Wiendl, H. The ups and downs of multiple sclerosis therapeutics. Ann Neurol 49, 281-4 (2001).
Greve, B., Magnusson, C.G., Melms, A. & Weissert, R. Immunoglobulin isotypes reveal a predominant role of type 1 immunity in multiple sclerosis. J Neuroimmunol 121, 120-5 (2001).
Forsthuber, T.G., Shive, C.L., Wienhold, W., de Graaf, K., Spack, E.G., Sublett, R., Melms, A., Kort, J., Racke, M.K. & Weissert, R. T cell epitopes of human myelin oligodendrocyte glycoprotein identified in HLA-DR4 (DRB1*0401) transgenic mice are encephalitogenic and are presented by human B cells. J Immunol 167, 7119-25 (2001).
Burk, K., Bosch, S., Muller, C.A., Melms, A., Zuhlke, C., Stern, M., Besenthal, I., Skalej, M., Ruck, P., Ferber, S., Klockgether, T. & Dichgans, J. Sporadic cerebellar ataxia associated with gluten sensitivity. Brain 124, 1013-9 (2001).
Burk, K., Melms, A., Schulz, J.B. & Dichgans, J. Effectiveness of intravenous immunoglobin therapy in cerebellar ataxia associated with gluten sensitivity. Ann Neurol 50, 827-8 (2001).
Bischof, F., Wienhold, W., Wirblich, C., Malcherek, G., Zevering, O., Kruisbeek, A.M. & Melms, A. Specific treatment of autoimmunity with recombinant invariant chains in which CLIP is replaced by self-epitopes. Proc Natl Acad Sci U S A 98, 12168-73 (2001).
2000
Wienhold, W., Malcherek, G., Jung, C., Stevanovic, S., Jung, G., Schild, H. & Melms, A. An example of immunodominance: engagement of synonymous TCR by invariant CDR3 beta. Int Immunol 12, 747-56 (2000).
Wiendl, H., Behrens, L., Maier, S., Johnson, M.A., Weiss, E.H. & Hohlfeld, R. Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G. Ann Neurol 48, 679-84 (2000).
Reinhardt, C. & Melms, A. Normalization of elevated CD4-/CD8- (double-negative) T cells after thymectomy parallels clinical remission in myasthenia gravis associated with thymic hyperplasia but not thymoma. Ann Neurol 48, 603-8 (2000).
Neuhaus, O., Farina, C., Yassouridis, A., Wiendl, H., Then Bergh, F., Dose, T., Wekerle, H. & Hohlfeld, R. Multiple sclerosis: comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells. Proc Natl Acad Sci U S A 97, 7452-7 (2000).
Herrlinger, U., Weller, M., Dichgans, J. & Melms, A. Association of primary central nervous system lymphoma with long-term azathioprine therapy for myasthenia gravis? Ann Neurol 47, 682-3 (2000).
Herrlinger, U., Klingel, K., Meyermann, R., Kandolf, R., Kaiserling, E., Kortmann, R.D., Melms, A., Skalej, M., Dichgans, J. & Weller, M. Central nervous system Hodgkin's lymphoma without systemic manifestation: case report and review of the literature. Acta Neuropathol (Berl) 99, 709-14 (2000).
1999
Tolosa E, Ashwell JD. Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell development. Neuroimmunomodulation 6(1-2):90-96 (1999)
King LB, Tolosa E, Lenczowski JR, Lu F, Lind EF, Hunziker R, Petrie HT, Ashwell JD. A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4-CD8- to CD4+CD8+ thymocytes. Int Immunol 11:1203-1216 (1999)
Hollander MC, Sheikh MS, Bulavin D, Lundgren D, Augeri-Henmueller L, Shehee R, Molinaro T, Kim K, Tolosa E, Ashwell JD, Rosenberg MD, Zhan Q, Fernández-Salguero PM, Morgan WF, Deng C-X, Fornace AJ Jr. Genomic instability in gadd45-deficient mice. Nature Genetics 23(2):176-184 (1999)
Reinhardt, C. & Melms, A. Elevated frequencies of natural killer T lymphocytes in myasthenia gravis. Neurology 52, 1485-7 (1999).
Bischof, F., Kuntz, R., Melms, A. & Fetter, M. Cerebral vein thrombosis in a case with thromboangiitis obliterans. Cerebrovasc Dis 9, 295-7 (1999).
Bischof, F., Melms, A. & Fetter, M. Persistent cerebellar deterioration in a patient with lobar pneumonia under lithium, carbamazepine, and trifluperidol treatment. Eur Psychiatry 14, 175-6 (1999).
1998
Tolosa E, King LB, Ashwell JD. Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice. Immunity 8:67-76 (1998).
Slesak, G., Melms, A., Gerneth, F., Sommer, N., Weissert, R. & Dichgans, J. Late-onset myasthenia gravis. Follow-up of 113 patients diagnosed after age 60. Ann N Y Acad Sci 841, 777-80 (1998).
Reinhardt, C. & Melms, A. Skewed TCRV beta repertoire in human thymus persists after thymic emigration: influence of genomic imposition, thymic maturation and environmental challenge on human TCRV beta usage in vivo. Immunobiology 199, 74-86 (1998).
Manz, M.G., Melms, A., Sommer, N. & Muller, C.A. Myasthenia gravis and tumor necrosis factor beta polymorphisms: linkage disequilibrium but no association beyond HLA-B8. J Neuroimmunol 90, 187-91 (1998).
Malcherek, G., Wirblich, C., Willcox, N., Rammensee, H.G., Trowsdale, J. & Melms, A. MHC class II-associated invariant chain peptide replacement by T cell epitopes: engineered invariant chain as a vehicle for directed and enhanced MHC class II antigen processing and presentation. Eur J Immunol 28, 1524-33 (1998).
Jung, C., Kalbus, M., Fleckenstein, B., Melms, A., Jung, G. & Wiesmuller, K.H. New ligands for HLA DRB1*0301 by random selection of favourable amino acids ranked by competition studies with undecapeptide amide sublibraries. J Immunol Methods 219, 139-49 (1998).
Bischof, F. & Melms, A. Polyclonal immunoglobulins induce apoptosis in a small proportion of peripheral lymphocytes in vitro. Ann N Y Acad Sci 841, 727-30 (1998).
Bischof, F. & Melms, A. Glucocorticoids inhibit CD40 ligand expression of peripheral CD4+ lymphocytes. Cell Immunol 187, 38-44 (1998).
Ausgewählte Arbeiten 1992 bis 1997
Weissert R, Melms A, Link H. (1997) Altered TGF-ß mRNA expression after thymectomy-related clinical remission in myasthenia gravis. J Neurol Sci 151:49- 55
Sospedra M, Tolosa E, Armengol P, Ashhab Y, Urlinger S, Lucas-Martin A, Foz-Sala M, Jaraquemada D, Pujol-Borrell R. Hyperexpression of transporter in antigen processing-1 (TAP-1) in thyroid glands affected by autoimmunity: a contributing factor to the breach of tolerance to thyroid antigens? Clin. Exp. Immunol., 109(1): 98-106 (1997)
Tolosa E, Shaw S. A fluorogenic assay of endogenous phosphatase for assessment of cell adhesion. J. Immunol. Methods, 192(1-2): 165-172 (1996)
Hawke S, Nagvekar, Nicolle M, Malcherek G, Melms A, Willcox N. (1996) Autoimmune T cells: Heterogeneity and potential as target for therapy. Immunol today 17:307-311
van Ham SM, Grüneberg U, Malcherek G, Bröker I, Melms A, Trowsdale J. (1996) Human Histocompatibility Leukocyte Antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs. J Exp Med 184:2019-2024
Malcherek G, Gnau V, Jung G, Rammensee HG, Melms A. (1995). Supermotifs enable natural invariant chain peptides to interact with many MHC class II molecules. J Exp Med 181:527-536
Malcherek G, Gnau V, Stevanovic S, Rammensee HG, Jung G, Melms A. (1994) Characterization of allele-specific contact sites of DR17 ligands. J Immunol 154: 1141-1149
Malcherek G, Falk K, Rötzschke O, Rammensee HG, Stevanovic S, Gnau V, Jung G, Melms A. (1993) Peptide motif of two HLA molecules associated with myasthenia gravis. Int Immunol 5:1229-1237
Melms A, Malcherek G, Gern U, Müller CA, Wiethölter H, Schoepfer R, Lindstrom J (1992). T cells from normal and myasthenic individuals recognize the human acetylcholine receptor: heterogeneity of antigenic sites on the alpha-subunit. Ann Neurol 31:311-318
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