The Laboratory of Functional Neurogenetics at the Hertie Institute for Clinical Brain Research, Tübingen (Germany) offers now or later 2009 a full time
PhD Student Position
The project is to study the mechanisms of neuronal dysfunction caused by pathological phosphorylation (with emphasis on the recently discovered polo-like kinases) and aggregation of the Parkinson's disease protein α-synuclein and explore immune therapeutic approaches. Transgenic mice and cell cultures are the primary model systems for this project. Methods include behavioral assays, experimental neuropathology, and a wide range of molecular, cellular and biochemical methods, as well as advanced imaging techniques.
We are looking for a highly motivated, team-oriented enthusiastic individual with a strong background in neuroscience animal research and molecular cell biology. Successful applicants will be enrolled in an Initial Training Network of the European Union 7th Framework Program and the Graduate Training Center of Neuroscience, University of Tübingen. Non-German residents, preferentially European citizens are eligible.
Interested individuals with a diploma/masters degree in life sciences (e.g. neuroscience, biology) are invited to send applications to:
Prof. Dr. Philipp Kahle
Laboratory of Functional Neurogenetics
Hertie Institute for Clinical Brain Research
Otfried Müller Str. 27
72076 Tübingen, Germany
Kahle et al. (2000) Subcellular localization of wild-type and Parkinson's disease-associated mutant α-synuclein in human and transgenic mouse brain. J. Neurosci. 20, 6365-6373
Neumann et al. (2002) Misfolded proteinase K-resistant and hyperphosphorylated α-synuclein in aged transgenic mice and in Lewy body disease patients. J. Clin. Invest. 110, 1429-1439
Freichel et al. (2007) Age-dependent cognitive decline and amygdala pathology in α-synuclein transgenic mice. Neurobiol. Aging 28, 1421-1435
Kahle (2008) α-Synucleinopathy models and human neuropathology: similarities and differences. Acta Neuropathol. 115, 87-95
Schell et al. (2009) Nuclear and neuritic distribution of serine-129 phosphorylated α-synuclein in transgenic mice. Neuroscience, in press