Sie sind hier: Arbeitsgruppen > Systemische Neurophysiologie (Schwarz)
Prof. Dr. rer. nat. Cornelius Schwarz
Tel. 07071 29 80462
Fax 07071 29 5724
Intrinsic and synaptic mechanisms determining cerebellar nuclei neurons spike output
Although all forms of cerebellar dysfunction are characterized by severe impairment in the timing of muscular activation and consequent uncoordinated movements, the cellular underpinnings of the cerebellum control of movement remains unknown. Our research is focused on the neurons of the deep cerebellar nuclei (DCN) which carry almost all cerebellar output signals and are the main target of the cerebellar cortex signals. Despite their central position in the cerebellar system, the internal micro-circuits and cellular mechanisms determining DCN output are still poorly understood. Moreover, in many types of cerebellar diseases, deep cerebellar nuclei neurons are spared and their function is altered only secondarily to the alterations occurring at the cerebellar cortex. Hence, cerebellar nuclei are a natural place for compensatory mechanisms for diseases affecting the cerebellar cortex. The general aim of this research is to understand the cellular mechanism that control DCNs output. Particularly, three areas are currently investigated:
Finally we are interested in the potential plasticity of the above mentioned mechanisms.