Das zentrale Ziel unseres Labors ist es, zu erforschen, wie dynamische Interaktionen weitverteilter Nervenzellpopulationen Kognition und Verhalten hervorbringen. Wie gehen aus den dynamischen neuronalen Interaktionen des Gehirns komplexe Prozesse wie Wahrnehmung, das Treffen von Entscheidungen oder motorisches Verhalten hervor? Welche neuronalen Mechanismen koordinieren diese Interaktionen, wie werden sie abhängig vom Verhaltenskontext reguliert und wie sind diese Interaktionen bei neuropsychiatrischen Erkrankungen gestört?
Um diese Fragen zu beantworten, verwenden wir einen interdisziplinären Mehrskalen-Ansatz und stellen Verbindungen zwischen Populationsmaßen neuronaler Aktivität und Mechanismen auf der zellulären und Schaltreisebene her. Hierfür kombinieren wir Magnet- und Elektroenzephalographie (MEG/EEG) am Menschen, elektrophysiologische Untersuchungen am Tiermodell, Psychophysik und hochentwickelte analytische Verfahren.
In English only
Spectral Fingerprints of Normal and Diseased Brain Function
One focus of the lab are oscillatory dynamics of neuronal activity. Brain activity exhibits oscillations, i.e. periodicity, at various different frequencies and spatial scales. These oscillations may not only serve as highly informative markers, or ‘spectral fingerprints’ of the circuit interactions involved in different cognitive functions but may also dynamically mediate these interactions.
In one line of research, we investigate these spectral fingerprints with MEG in the resting human brain. We investigate how networks of brain regions spontaneously coordinate their oscillations at different frequencies. Together with our clinical collaborators, we investigate these rhythmic networks as novel biomarkers of different neurological pathologies. Furthermore, we characterize the temporal microstructure of different brain rhythms and how they are linked to neuronal spiking at the cellular level.
Neuronal Dynamics During Cognition and Behavior
In another line of research, we investigate neural dynamics underlying specific cognitive functions. We characterize the flow of information and neuronal interactions across distributed cortical and sub-cortical networks during complex behavioral tasks, involving e.g. visual and auditory decision-making, attention, working memory, and proprioception. We investigate how sensory, cognitive, and motor neuronal information flows across the brain and how such information relates to neuronal oscillations, dynamics and interactions. Together with our clinical collaborators, we investigate alterations of neuronal dynamics during pathological conditions, such as e.g. dyslexia in children and spatial hearing in cochlear implant users.
Magnetoencephalography – Imaging Human Brain Dynamics
Magnetoencephalography (MEG) allows for non-invasively and directly measuring human brain activity with unparalleled temporal resolution and signal quality. Our lab operates the Tübingen MEG Center, which provides state-of-the-art MEG techniques and services to the Tübingen neuroscience community and beyond. The MEG Center hosts a 275-channels whole-head MEG system, synchronized high-density EEG, transcranial electrical stimulation, precise visual, auditory and somatosensory stimulation, various response systems and high-speed binocular eye-tracking. The MEG Center is involved in a broad spectrum of collaborative research projects with partners at the Center for Neurology, the Centre for Integrative Neuroscience, the Institute of Medical Psychology, the Department of Otolaryngology, the Centre for Ophthalmology, the Department of Psychiatry and Psychotherapy and the Department of Psychosomatic Medicine.
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Ausgewählte Publikationen
· Pellegrini F, Hawellek DJ, Pape AA, Hipp JF, Siegel M (2020) Motion Coherence and Luminance Contrast Interact in Driving Visual Gamma-Band Activity. Cerebral Cortex ePub
· Siems M, Siegel M (2020) Dissociated neuronal phase- and amplitude-coupling patterns in the human brain. Neuroimage 209:116538
· Trainito C, von Nicolai C, Miller EK, Siegel M (2019) Extracellular spike waveform dissociates four functionally distinct cell classes in primate cortex. Current Biology 29
· Fioravanti C, Kajal SD, Carboni M, Mazzetti C, Ziemann U, Braun C (2019) Inhibition in the somatosensory system: An integrative neuropharmacological and neuroimaging approach. Neuroimage; 202:116139.
· Sandhaeger F, von Nicolai C, Miller EK, Siegel M (2019) Monkey EEG links neuronal color and motion information across species and scales. eLife 8:e45645
· Wang H, Braun C, Murphy EF, Enck P (2019) Bifidobacterium longum 1714™ Strain Modulates Brain Activity of Healthy Volunteers During Social Stress. Am J Gastroenterol; 114(7):1152-1162
· Broser PJ, Knappe S, Kajal DS, Noury N, Alem O, Shah V, Braun C (2018) Optically Pumped Magnetometers for Magneto-Myography to Study the Innervation of the Hand. IEEE Trans Neural Syst Rehabil Eng; 26(11): 2226-2230.
· Pape AA and Siegel M (2016) Motor cortex activity predicts response alternation during sensorimotor decisions. Nature Communications 7:13098
· Siegel M, Buschman TJ and Miller EK (2015) Cortical Information Flow During Flexible Sensorimotor Decisions. Science 348(6241): 1352-55
· Hipp JF and Siegel M (2015) BOLD fMRI Correlation Reflects Frequency-Specific Neuronal Correlation. Current Biology 25, 1368-1374
· Weisz N, Wühle A, Monittola G, Demarchi G, Frey J, Popov T, Braun C. (2014). Prestimulus oscillatory power and connectivity patterns predispose conscious somatosensory perception. PNAS.;111(4): E417-425.
· Hipp JF, Hawellek DJ, Corbetta M, Siegel M and Engel AK (2012) Large-scale cortical correlation structure of spontaneous oscillatory activity. Nature Neuroscience 15:884-890
· Siegel M, Donner TH and Engel AK (2012) Spectral fingerprints of large-scale neuronal interactions. Nature Reviews Neuroscience 13:121-134
· Hipp JF, Engel AK and Siegel M (2011) Oscillatory Synchronization in Large-Scale Cortical Networks Predicts Perception. Neuron 69: 387-396
· Siegel M, Warden MR and Miller EK (2009) Phase-Dependent Neuronal Coding of Objects in Short-Term Memory. PNAS 106(50): 21341–21346
· Siegel M, Donner TH, Oostenveld R, Fries P and Engel AK (2008) Neuronal Synchronization along the Dorsal Visual Pathway Reflects the Focus of Spatial Attention. Neuron 60: 709-719
· Miltner WHR, Braun C, Arnold M, Witte H, Taub E (1999) Coherence of gamma-band EEG activity as a basis for associative learning. Nature, 397: 434-436.
Zentrum für Neurologie
Hertie-Institut für klinische Hirnforschung
Abteilung Neuronale Dynamik und Magnetenzephalographie
Otfried-Müller-Straße 25
72076 Tübingen
Tel.: +49 (0)7071 29-81200 / 85297
Fax: +49 (0)7071 29-25002
