FG Thier

Kognitive Neurologie

Die enorme Anzahl an Fasern, die der Großhirnrinde entspringen und über die pontinen Kerne in das Kleinhirn projizieren, weisen den cerebro-ponto-cerebellären Pfad als eine wichtige Instanz der sensomotorischen Integration aus. Er vereint schon auf der Ebene der pontinen Kerne sensorische Eingänge, z.B. visuelle oder auditorische Signale, mit Motorsignalen der Extremitäten und der Augen. Bei den Untersuchungen über die funktionelle Architektur der Brückenkerne geht es um die Frage, ob die Informationsströme, die ihren Ursprung in verschiedenen Teilen des cerebralen Cortex nehmen, auf der Ebene der Brückenkerne miteinander interagieren.

Untersuchungen, die dem Kleinhirn gelten, befassen sich mit der Frage, ob das Kleinhirn tatsächlich, wie seit Marr und Albus vermutet, ein wesentliches Instrument des motorischen Lernens ist. Sie versuchen zu klären, welche neuronalen Mechanismen dem motorischen Lernen zugrunde liegen. Die Arbeitshypothese, die in Experimenten an nichthumanen Primaten verfolgt wird, ist, dass der cerebelläre Cortex motorische Programme kontinuierlich, auf einer Zeitskala von Sekunden bis Minuten, an die sich stetig verändernden Eigenschaften der Effektoren und der Umwelt, mit der die Effektoren interagieren, anpasst. Die Grundlagen des motorischen Lernens werden am Beispiel des sakkadischen Lernens untersucht, wobei experimentelle Läsionen sowie Einzel- und Multielektrodenableitungen zum Einsatz kommen. Die Arbeitsgruppe interagiert mit der Wahrnehmungsarbeitsgruppe (Labor für Visuelle Wahrnehmung), wenn sie den Gedanken verfolgt, dass zerebelläre Beiträge zur Wahrnehmung darauf basieren könnten, dass das Kleinhirn interne Modelle motorischer Leistungen, die die Wahrnehmung beeinflussen, anbietet, die in ganz ähnlicher Weise wie die internen Modelle, die zur Optimierung motorischer Leistungen dienen, fortwährend angepasst werden.

Forschungsprojekte
Mitarbeitende
Publikationen
Partner und Kooperationen
  • Rolle des Kleinhirns für das motorische Lernen, Adaptation und Rekalibration schneller Augenbewegungen
  • Rolle des Kleinhirns für die Wahrnehmung von Bewegungsreizen
  • Rolle des frontalen Cortex und des superioren Colliculus für die präzise Ausrichtung räumlicher Aufmerksamkeit
  • Integration von Augen- und Handbewegungen in den Brückenkernen

 
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 Ruediger Berndt
Ruediger BerndtTechnical Assistant
Cognitive Neurology

+49 (0) 7071
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 Ian Chong
Ian ChongPhD Student
Cognitive Neurology


 
Dr.  Peter W. Dicke
Dr. Peter W. DickeLab management
Cognitive Neurology

+49 (0)7071-
29-81936

 
 Marius Görner
Marius GörnerPhD Student
Cognitive Neurology

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 Dagmar Heller-Schmerold
Dagmar Heller-SchmeroldAdministrative Coordinator
Cognitive Neurology

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 Junya Inoue
Junya InouePhD Student
Cognitive Neurology


 
 Lilei Peng
Lilei PengPhD Student
Cognitive Neurology

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 Masih Shafiei
Masih ShafieiPhD Student
Cognitive Neurology

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 Ramona Siebert
Ramona SiebertPhD Student
Cognitive Neurology

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 Weronika Sojka
Weronika SojkaMaster Student
Cognitive Neurology


 
Dr. Silvia Spadacenta
Dr. Silvia SpadacentaPostdoc
Cognitive Neurology

+49 (0)7071-
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Prof. Dr. Hans-Peter Thier
Prof. Dr. Hans-Peter ThierResearch Group Leader
Cognitive Neurology

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2022

Barash S, Spivak O, Thier P (2022) The scotopic band: primate detailed scotopic vision and perceptual incertainty. BioRxiv 2022.01.25.477659; doi: doi.org/10.1101/2022. 01.25.477659

Khazali M, Daddaoua N, Thier P (2022) Nonhuman primates exploit the prior assumption that the visual world is vertical. BioRxiv 2022.10.28.514095; doi: doi.org/10.1101/2022.10.28.514095

Markanday A, Inoue J, Vialkowitsch P,  Thier P (2022) An interactive platform for detecting cerebellar complex spikes. J Neurophysiol 128 (2):434-435; doi: 10.1152/jn.00297.2022

Shams Ahmar M, Thier P, Merrikhi Y (2022). Dissociable roles of FEF neurons in initiating saccades. BioRxiv 2022.02.01.4786509; doi: doi.org/10.1101/2022. 02.01.478650

Spadacenta S, Dicke PW, Thier P (2022) A prosocial function of head-gaze aversion and head-cocking in common marmosets. Primates 63(5):535-546; doi: 10.1007/s10329-022-00997-z. Epub 2022 Jul 15.

Stettler M, Taubert N, Siebert R, Spadacenta S, Dicke P, Thier P, Giese M (2022) Norm-referenced neural mechanism for the recognition of facial expressions across fundamentally different face shapes. J Vis 22:, 3398; doj:https://doi.org/10.1167/jov.22.14.3398. Vision Sciences Society Annual Meeting Abstract.

Sun Z, Dicke PW, Thier P (2022) Differential kinematic encoding of saccades and smooth-pursuit eye movements by fastigial neurons. Neurosci Bull 38(8):927-932; doi: 10.1007/s12264-022-00857-2. Epub 2022 Apr 29.

2021

Ramezanpour H, Görner M, Thier P (2021) Variability of neuronal responses in the posterior superior temporal sulcus predicts choice behavior during social interactions. J Neurophysiol 126(6):1925-1933. doi: 10.1152/jn.00194.2021. Epub 2021 Oct 27. PMID: 34705592

Spivak O, Thier P, Barash S (2021) Dark-habituation increases the dark-background-contingent upshift of gaze in macaque monkeys. Vision Res 188:262-273. doi: 10.1016/j.visres.2021.07.011. Epub 2021 Sep 1. PMID: 34481167

Shams-Ahmar M, Thier P (2021) Sensitivity of express saccades to the expected value of the target. J Neurophysiol 125(1):238-247. doi: 10.1152/jn.00172.2020. Epub 2020 Dec 9. PMID: 33296613

Markanday A, Inoue J, Dicke PW, Thier P (2021) Cerebellar complex spikes multiplex complementary behavioral information. PLoS Biol 19(9):e3001400. doi: 10.1371/journal.pbio.3001400. eCollection 2021 Sep. PMID: 34529650 Free PMC article.

Taubert N, Stettler M, Siebert R, Spadacenta S, Sting L, Dicke P, Thier P, Giese MA (2021) Shape-invariant encoding of dynamic primate facial expressions in human perception. eLife;10:e61197. doi: 10.7554/eLife.61197. PMID: 34115584 Free PMC article.

Markanday A, Thier P (2021) The Quest for a Unifying Framework for the Role of Cerebellar Complex Spikes. In: Cerebellum as a CNS hub; Mizusawa H,  Kakei S (eds). Contemporary Clinical Neuroscience Series, Springer Nature Switzerland, pp 277-304. ISBN 978-3-030-75816-5; ISBN 978-3-030-75817-2 (eBook)2020

2020

Görner M, Ramezanpour H, Chong I, Thier P (2020) Does the brain encode the gaze of others as beams emitted by their eyes? Proc Natl Acad Sci U S A 117(34):20375-20376. doi:10.1073/pnas.2012462117.

Khazali MF, Ramezanpour H, Thier P (2020) V1 neurons encode the perceptual compensation of false torsion arising from Listing's law. Proc Natl Acad Sci U S A. 117(31):18799-18809. doi:10.1073/pnas.2007644117.

Kraemer P, Görner M, Ramezanpour H, Dicke P, Thier P (2020) Frontal, parietal and temporal brain areas are differentially activated when disambiguating potential objects of joint attention. eNeuro 0437-19.2020. doi:10.1523/ENEURO.0437-19.2020.

Markanday A*, Bellet J*, Bellet ME, Inoue J, Hafed ZM**, Thier P** (2020) Using deep neural networks to detect complex spikes of cerebellar Purkinje cells. Journal of Neurophysiology 123:2217-2234. (*: contributed equally; **: co-corresponding authors)

Pomper JK, Spadacenta S, Bunjes F, Arnstein D†, Giese M, Thier P (2020) Representation of the observer’s predicted outcome value in mirror and nonmirror neurons of macaque F5 ventral premotor cortex. J Neurophysiol 124(3):941-961. doi: 10.1152/jn.00234.2020.

Ramezanpour H, Thier P (2020) Decoding of the other’s focus of attention by a temporal cortex module. Proc Natl Acad Sci USA 117(5):2663-2670. doi: 10.1073/pnas.1911269117.

Siebert R, Taubert N, Spadacenta S, Dicke PW, Giese MA, Thier P (2020) A naturalistic dynamic monkey head avatar elicits species-typical reactions and overcomes the uncanny valley. eNeuro.0524-19.2020.

Stettler M, Taubert N, Azizpour T, Siebert R, Spadacenta S, Dicke P, Thier P, Giese MA (2020) Physiologically-inspired neural circuits for the recognition of dynamic faces. In:  ICANN 2020, Farkas et al. (eds.), Springer Nature Switzerland AG 2020?I., LNCS 12396, pp. 168–179; doi.org/10.1007/978-3-030-61609-0_14

2019

Flierman NA, Ignashchenkova A, Negrello M, Thier P, De Zeeuw CI, Badura A (2019) Glissades are altered by lesions to the oculomotor vermis but not by saccadic adaptation. Front Behav Neurosci. 13:194; doi: 10.3389/fnbeh.2019.00194. eCollection 2019.

Spadacenta S, Dicke PW, Thier P (2019) Reflexive gaze following in common marmoset monkeys. Scientific Reports 9(1):15292; doi: 10.1038/s41598-019-51783-9.

Stettler M, Taubert N, Sting L, Siebert R, Spadacenta S, Dicke P et al (2019) Cross-species differences
in the perception of dynamic facial expressions. Talk at ECVP Conference 2019, Perception 48(2S):63.

Taubert N, Stettler M, Sting L, Siebert R, Spadacenta S, Dicke P et al (2019) Cross-species differences
in the perception of dynamic facial expressions. VSS Annual Meeting 2019, Journal of Vision
19(10):155. doi: doi.org/10.1167/19.10.155

Thier P, Markanday A (2019) Role of the vermal cerebellum in visually guided eye movements and visual motion perception. Annu Rev Vis Sci 5:247-268; doi: 10.1146/annurev-vision-091718-015000. Epub 2019 Jul 12.

2018

Junker M, Endres D, Sun ZP, Dicke PW, Giese M, Thier P (2018) Learning from the past: a memory trace of errors in the cerebellar climbing fiber signal. PloS Biology 16(8):e2004344. doi: 10.1371/journal.pbio.2004344. eCollection 2018 Aug.

Markanday A, Messner J, Thier P (2018) Motivation signals help the cerebellum to prevent future motor errors. European Journal of Neuroscience 48(4):1976-1989. doi: 10.1111/ejn.14062.

Spivak O, Thier P, Barash S (2018) Monkeys use the rod?dense retinal region rather than the fovea to visually fixate small targets in scotopic vision. BioRxiv, doi:http://dx.doi.org/10.1101/290759

2017

Höller-Wallscheid MS, Thier P, Pomper JK, Lindner A (2017) Bilateral recruitment of prefrontal cortex in working memory is associated with task demand but not with age. Proceedings of the National Academy of Sciences USA, doi:10.1073/pnas.1601983114 [Epub ahead of print].

Marquardt K, Ramezanpour H, Dicke PW, Thier P (2017) Following eye gaze activates a patch in the posterior temporal cortex that is not part of the human "face patch" system. eNeuro, DOI: 10.1523/ENEURO.0317-16.2017

Sun Z-P, Smilgin A, Junker M, Dicke PW, Thier P (2017) The same oculomotor vermal Purkinje cells encode the very different kinematics of saccades and of smooth pursuit eye movements. Scientific Reports 7:40613. doi: 10.1038/srep40613.

2016

Caggiano V, Fleischer F, Pomper JK, Giese MA, Thier P (2016) Mirror neurons in monkey premotor area f5 show tuning for critical features of visual causality perception. Current Biology 26(22):3077-3082. doi: 10.1016/j.cub.2016.10.007.

Hong S, Negrello M, Junker M, Smilgin A, Thier P, De Schutter E (2016) Multiplexed coding by cerebellar Purkinje neurons. eLife, doi: 10.7554/eLife.13810.

Khazali M, Pomper J, Smilgin A, Bunjes F, Thier P (2016) A new motor synergy that serves the needs of oculomotor and eye lid systems while keeping the downtime of vision minimal. eLife 5:e16290.

Roth MJ, Lindner A, Thier P (2016) Visual circuits. In: Essentials of Cerebellum and Cerebellar Disorders. Gruol DL, Koibuchi N, Manto M, Molinari M, Schmahmann JD, Shen Y (eds), Berlin-Heidelberg, pp. 89-100.

Sun Z-P, Barash S, Thier P (2016) The role of the cerebellum in optimizing saccades. In: The Neuronal Codes of the Cerebellum. Heck D (ed), Elsevier Science Publishers, pp 173-196.

Sun Z-P, Junker M, Dicke PW, Thier P (2016) Individual neurons in the caudal fastigial oculomotor region convey information on both macro- and microsaccades. European Journal of Neuroscience 44(8):2531-2542, doi: 10.1111/ejn.13289. [Epub ahead of print].

Wilke C, Pomper JK, Biskup S, Puskás C, Berg D, Synofzik M (2016) Atypical parkinsonism in C9orf72 expansions: a case report and systematic review of 45 cases from the literature. J Neurol 263(3):558-574. doi: 10.1007/s00415-016-8021-7.

2015

Arnstein D, Dicke PW, Junker MA, Smilgin A, Thier P (2015) Microsaccade control signals in the cerebellum. Journal of Neuroscience 35(8):3403-11. doi: 10.1523/JNEUROSCI.2458-14.2015.

Atabaki A, Marciniak K, Dicke PW, Thier P (2015) Assessing the precision of gaze following using a stereoscopic 3D virtual reality setting. Vision Research 112:68-82

Caggiano V, Giese M, Thier P, Casile A (2015) Encoding of point of view during action observation in the Local Field Potentials of macaque area F5. European Journal of Neuroscience 41(4):466-476.

Chen C-Y, Ignashchenkova A, Thier P, Hafed Z (2015) Neuronal Response Gain Enhancement prior to Microsaccades . Current Biology 25(16): 2065-2074

Marciniak K, Dicke PW, Thier P (2015) Monkeys’ head gaze following is fast, precise and not fully suppressible. Proceedings of the Royal Society B 282:20151020

Pomper JK, Arnstein D, Caggiano C, Giese M, Thier P (2015) New properties of F5 mirror neurons and their implications for response selection. In: New Frontiers in Mirror Neurons Research. Ferrari PF, Rizzolatti G (eds), Oxford University Press, pp. 39-57.

Srulijes K, Mack DJ, Klenk J, Schwickert L, Ihlen EA, Schwenk M, Lindemann U, Meyer M, K CS, Hobert MA, Brockmann K, Wurster I, Pomper JK, Synofzik M, Schneider E, Ilg U, Berg D, Maetzler W, Becker C (2015) Association between vestibulo-ocular reflex suppression, balance, gait, and fall risk in ageing and neurodegenerative disease: protocol of a one-year prospective follow-up study. BMC Neurology 15(1):192.

Warnaar P, Couto J, Negrello M, Junker M, Smilgin A, Gigliano M, Thier P, De Schutter E (2015) Complex spike waveforms in the awake monkey are determined by the interval tot he previous complex spike. Frontiers in Cellular Neuroscience 9:122

2014

Atabaki A, Marciniak K, Dicke PW, Karnath H-O, Thier P (2014) Parietal BOLD response evoked by covert visual search reflects set-size effect in monkeys. European Journal of Neuroscience 39:832-840

Caggiano V, Giese M, Thier P, Casile A (2014) Encoding of point of view during action observation in the Local Field Potentials of macaque area F5. European Journal of Neuroscience; doi: 10.1111/ejn.12793. [Epub ahead of print]

Daddaoua N, Dicke PW, Thier P (2014) Eye position information is used to compensate the consequences of ocular torsion on V1 receptive fields. Nature Communications 5:3047. doi: 10.1038/ncomms4047

Dash S, Thier P (2014) Cerebellum-dependent motor learning: lessons from adaptation of eye movements in primates. Progress in Brain Research 210:121-55

Marciniak K, Atabaki A, Dicke PW, Thier P (2014) Disparate substrates for head gaze following and face perception in the monkey superior temporal sulcus. Elife; e03222. doi: 10.7554/eLife.03222

Spivak O, Thier P, Barash S (2014) Persistence of the dark-background-contingent gaze upshift during visual fixations of rhesus monkeys. Journal of Neurophysiology 112(8):1999-2005. doi: 10.1152/jn.00666.2013

2013

Atabaki A, Dicke PW, Karnath HO, Thier P (2013) The dependencies of fronto-parietal BOLD responses evoked by covert visual search suggest eye-centred coding. Eur J Neurosci 37(8):1320-1329.

Caggiano V, Pomper J, Fleischer F, Fogassi L, Giese MA, Thier P (2013) Mirror neurons in monkey area F5 do not adapt to the observation of repeated actions. Nat Commun 4:1433.

Dash S, Dicke PW, Thier P (2013) A vermal Purkinje cell simple spike population response encodes the changes in eye movement kinematics due to smooth pursuit adaptation. Frontiers in Systems Neuroscience 7, 3:1-14. doi: 10.3389/fnsys.2013.00003

Dash S, Thier P (2013) Smooth pursuit adaptation (SPA) exhibits features useful to compensate changes in the properties of the smooth pursuit eye movement system due to usage, Frontiers in Systems Neuroscience. doi: 10.3389/fnsys.2013.00067

Fleischer F, Caggiano V, Thier P, Giese MA (2013) Physiologically inspired model for the visual recognition of transitive hand actions. J Neurosci 15(33):6563-6580

2012

Albert MV, Catz N, Thier P, Kording K (2012) Saccadic gain adaptation is predicted by the statistics of natural fluctuations in oculomotor function. Front Comput Neurosci 6:96:1-7. doi: 10.3389/fncom.2012.00096

Büchel C, Karnath H-O, Thier P (2012) Methoden der kognitiven Neurowissenschaften. In: Kognitive Neurowissenschaften. Karnath H-O, Thier P (eds). Springer Verlag Berlin-Heidelberg, 9-32

Caggiano V, Fogassi L, Rizzolatti G, Casile A, Giese MA, Thier P (2012) Mirror neurons encode the subjective value of an observed action. PNAS 109(29):11848-11853.

Dash S, Catz N, Dicke PW, Thier P (2012) Encoding of smooth-pursuit eye movement initiation by a population of vermal purkinje cells. Cerebral Cortex 22(4):877-891

Fleischer F, Christensen A, Caggiano V, Thier P, Giese MA (2012) Neural theory for the perception of causal actions. Psychological Research 76:476-493

Ilg U, Thier P (2012) Neuronale Grundlagen visueller Wahrnehmung. In: Kognitive Neurowissenschaften. Karnath H-O, Thier P (eds). Springer Verlag Berlin-Heidelberg, 35-43

Ilg U, Thier P (2012) Zielgerichtete Augenbewegungen. In: Kognitive Neurowissenschaften. Karnath H-O, Thier P (eds). Springer Verlag Berlin-Heidelberg, 377-388

Karnath H-O, Thier P (2012) Kognitive Neurowissenschaften. 3. Auflage, Springer Verlag Berlin-Heidelberg.

Sultan F, Augath M, Hamodeh S, Murayama Y, Oeltermann A, Rauch A, Thier P. (2012) Unravelling cerebellar pathways with high temporal precision targeting motor and extensive sensory and parietal networks. Nat Commun. 3:924 (DOI: 10.3410/f.717959329.793462732)

Thier P (2012) Anatomie und Physiologie des parietalen Kortex. In: Kognitive Neurowissenschaften. Karnath H-O, Thier P (eds). Springer Verlag Berlin-Heidelberg, 225-240

Thier P (2012) Grundlagen zielgerichteter Motorik. In: Kognitive Neurowissenschaften. Karnath H-O, Thier P (eds). Springer Verlag Berlin-Heidelberg, 355-365

Thier P (2012) Die funktionelle Architektur des präfrontalen Kortex. In: Kognitive Neurowissenschaften. Karnath H-O, Thier P (eds). Springer Verlag Berlin-Heidelberg, 575-583

Thier P (2012) Kleinhirn und visuelle Wahrnehmung. In: Kognitive Neurowissenschaften. Karnath H-O, Thier P (eds). Springer Verlag Berlin-Heidelberg, 619-623

Tziridis K, Dicke PW, Thier P (2012) Pontine reference frames for the sensory guidance of movement. Cerebral Cortex 22(2):345-362

2011

Caggiano V, Fogassi L, Rizzolatti G, Pomper JK, Thier P, Giese MA*, Casile A*(*equal contribution) (2011) View-based encoding of actions in mirror neurons of area f5 in macaque premotor cortex. Curr Biol. 21(2):144 -148.

Daddaoua N, Dicke PW, Thier P (2011) Non-human primates exhibit disconjugate ocular counterroll to head roll tilts. Vision Research 51:1986-1993.

Dash S, Catz N, Dicke PW, Thier P (2011) Encoding of smooth-pursuit eye movement initiation by a population of vermal purkinje cells. Cerebral Cortex. [Epub ahead of print]. doi: 10.1093/cercor/bhr153

Laube I, Kamphuis S, Dicke PW, Thier P (2011). Cortical processing of head- and eye-gaze cues guiding joint social attention. Neuroimage 54(2):1643-1653. DOI 10.1016/j.neuroimage.2010.08.074

Prsa M, Thier P (2011) The role of the cerebellum in saccadic adaptation as a window into neural mechanisms of motor learning. Eur J Neurosci 33:2114-2128.

Thier P (2011) The oculomotor cerebellum. In: Oxford University Press Handbook of Eye Movements. Oxford University Press, 173-193.

Tziridis K, Dicke PW, Thier P (2011) Pontine reference frames for the sensory guidance of movement. Cerebral Cortex. [Epub ahead of print].  doi: 10.1093/cercor/bhr109

2010

Dash S, Catz N, Dicke PW, Thier P (2010) Specific vermal complex spike responseses build up during the course of smooth-pursuit adaptation, paralleling the decrease of performance error. Exp Brain Res 205:41-55

Prsa M, Dicke PW, Thier P (2010) The absence of eye muscle fatigue indicates that the nervous system compensates for non-motor disturbances of oculomotor function. J. Neuroscience 30:15834-15842.

Synofzik M, Thier P, Leube DT, Schlotterbeck P, Lindner A (2010) Misattributions of agency in schizophrenia are based on imprecise predictions about the sensory consequences of one’s actions. Brain 133:262-271. doi:10.1093/brain/awp291

Zrenner C, Eytan D, Wallach A, Thier P, Marom S (2010) A generic framework for real-time multi-channel neuronal signal analysis, telemetry control, and sub-millisecond latency feedback generation. Frontiers in Neuroscience 4:173-184

2009

Caggiano V, Fogassi L, Rizzolatti G, Thier P, Casile A. Mirror neurons differentially encode the peripersonal and extrapersonal space of monkeys. Science 2009;324:403-406

Dash S, Dicke PW, Chakraborty S, Haarmeier T, Thier P.  Demonstration of an eye movement induced visual motion illusion (Filehne illusion) in Rhesus monkeys. J Vision 2009. In press.

Fleischer F, Casile A, Giese MA. Physiologically-inspired model for the visual tuning properties of mirror neurons. Proceedings of the 2008 International Conference on Cognitive Systems, University of Karlsruhe, Karlsruhe, Germany, April 2-4, 2008, Springer-Verlag 2009. In press.

Ilg UJ, Thier P. The neural basis of smooth pursuit eye movements in the rhesus monkey brain. Brain & Cognition 2009; doi:10.1016/j.bandc.2008.08.014

2008

Bock S, Dicke PW, Thier P. How precise is gaze following in humans? Vision Res 2008;48:946-957

Catz N, Dicke PW, Thier P. Cerebellar-dependent motor learning is based on pruning a Purkinje cell population response. PNAS 2008;105(20):7309-7314

Daddaoua N, Dicke PW, Thier P. The subjective visual vertical in a nonhuman primate. Journal of Vision 2008;8(3):19, 1-8, journalofvision.org/8/3/19/, doi:10.1167/8.3.19.

Dicke PW, Chakraborty S, Thier P. Neuronal correlates of perceptual stability during eye movements. Europ J Neurosci 2008;27:991-1002

Fleischer F, Casile A, Giese MA. Neural Model for the Visual Recognition of Goal-directed Movements. In: Kurkova V, Neruda R, Koutnik J (eds.). ICANN 2008, Part II, LNCS 5164, pp 939-948

Händel B, Lutzenberger W, Thier P, Haarmeier T. Selective attention increases the dependency of neuromagnetic responses on visual motion coherence. Cerebral Cortex  2008;18:2902-2908

Ilg UJ, Thier P. The neural basis of smooth pursuit eye movements in the rhesus monkey brain. Brain and Cognition 2008;68:229-240

Materna S, Dicke PW, Thier P. Dissociable roles of the superior temporal sulcus and the intraparietal sulcus in joint attention: an fMRI study. J Cogn Neurosci 2008;20:108-119

Materna S, Dicke PW, Thier P. The posterior superior temporal sulcus is involved in social communication not specific for the eyes. Neuropsychologia 2008;46:2759-2765

2007

Catz N, Thier P. Neural control of saccadic eye movements. Neuro-Ophthalmology, Developments in Ophthalmology 2007;40:52-75

Dayan E, Casile A, Levit-Binnun N, Giese MA, Hendler T, Flash T. Neural representations of kinematic laws of motion: evidence for action-perception coupling. Proc Natl Acad Sci USA 2007;104(51):20582-20587

Graf M, Reitzner B, Corves C, Casile A, Giese MA, Prinz W. Predicting point-light actions in real. Neuroimage 2007;36 Suppl 2:T22-32

Haarmeier T, Thier P. The attentive cerebellum - fact or myth? Cerebellum 2007;6:177-183

Händel B, Lutzenberger W, Thier P, Haarmeier T. Opposite dependencies on visual motion coherence in human area MT+ and early visual cortex. Cerebral Cortex 2007;17:1542-1549.

Ilg W, Golla H, Thier P, Giese MA. Specific influences of cerebellar dysfunctions on gait. Brain 2007;130:786-798

Ilg W, Roehrig R, Thier P, Giese MA. Learning-based methods for the analysis of intra-limb coordination and adaptation of locomotor patterns in cerebellar patients. IEEE 10th International Conference on Rehabilitation Robotics, Noordwijk, The Netherlands, 2007, 1090-1095

Maschke M, Jahn K, Thier P. Alkoholfolgekrankheiten. In: Therapie und Verlauf neurologischer Erkrankungen. Brandt T, Dichgans J, Diener HC (eds). 5. Auflage, Kohlhammer, Stuttgart, 2007, 797-817

Thier P, Golla H. Rehabilitation zerebraler Sehstörungen. In: Therapie und Verlauf neurologischer Erkrankungen. Brandt T, Dichgans J, Diener HC (eds). 5. Auflage, Kohlhammer, Stuttgart, 2007, 288-293

Tikhonov A, Händel B, Haarmeier T, Lutzenberger W, Thier P. Gamma oscillations underlying the visual motion aftereffect. Neuroimage 2007;38:708-719

2006

Büchel C, Karnath H-O, Thier P. Methoden der Kognitiven Neurowissenschaften. In: H-O Karnath, P Thier (eds) Neuropsychologie. 2. Auflage. Springer, Heidelberg, 2006, pp 7-29

Casile A, Giese MA. Non-visual motor learning influences the recognition of biological motion. Current Biology 2006;16(1):69-74

Casile A, Rucci M. A theoretical analysis of the influence of fixational instability on the development of thalamo-cortical connectivity. Neural Computation 2006;18:569-590

Haarmeier T, Thier P. The detection of speed changes during pursuit eye movements. Exp Brain Res 2006;170:345-357

Haendel B, Lutzenberger W, Thier P, Haarmeier T. Opposite dependencies on visual motion coherence in human area MT+ and early visual cortex. Cerebral Cortex, advance access published August 28, 2006

Karnath H-O, Thier P (eds) Neuropsychologie. 2. Auflage. Springer-Verlag, Heidelberg, 2006

Lindner A, Haarmeier T, Erb M, Grodd W, Thier P. Cerebro-cerebellar circuits for the perceptual cancellation of eye-movement-induced retinal image motion. J Cogn Neurosci 2006;18(11):1899-1912

Lindner A, Haarmeier T, Thier P. Die inferentielle Natur der Wahrnehmung: Die Bedeutung des Reafferenzprinzips für das Bewegungssehen. Neuroforum 2006;1:160-165

Linnemann C, Schmeh I, Thier P, Schwarz C. Transient change in GABAA receptor subunit mRNA expression in Lurcher cerebellar nuclei during Purkinje cell degeneration. BMC Neuroscience 2006;7: 59

Thier P. Anatomie und Physiologie des parietalen Kortex. In: Karnath H-O, Thier P (eds) Neuropsychologie. 2. Auflage. Springer, Heidelberg, 2006, 161-176

Thier P. Grundlagen zielgerichteter Motorik. In: Karnath H-O, Thier P (eds) Neuropsychologie. 2. Auflage. Springer, Heidelberg, 2006, 275-285

Thier P. Die funktionelle Architektur des präfrontalen Kortex. In: Karnath H-O, Thier P (eds) Neuropsychologie. 2. Auflage. Springer, Heidelberg, 2006, 471-478

Thier P. Visuelle Wahrnehmung. In: Karnath H-O, Thier P (eds) Neuropsychologie. 2. Auflage. Springer, Heidelberg, 2006, 503-511

Thier P, Möck M. The oculomotor role of the pontine nuclei and the nucleus reticularis tegmenti pontis. Progr Brain Res 2006;151:293-320

2005

Casile A, Giese MA. Critical features for the recognition of biological motion. Journal of Vision 2005;5:348-360

Catz N, Dicke PW, Thier P. Cerebellar complex spike firing is suitable to induce as well as stabilize motor learning. Curr Biol 2005;15:2179-2189

Golla H, Thier P. Ocular flutter - a sign of brain-stem pathology as rare consequence of cyclosporin A treatment. Neurooptahlmol 2005;29:81-84

Golla H, Thier P, Haarmeier T. Disturbed overt but normal covert shifts of attention in adult cerebellar patients. Brain 2005;128:1525-1535

Ignashchenkova A, Haarmeier T, Thier P. The role of the superior colliculus in covert shifts of attention. In: Ilg UJ,  Bülthoff HH, Mallot H (eds.) Dynamic Perception. Workshop of the GI Section "Computer Vision". Infix, Akademische Verlagsgesellschaft Aka (Berlin) and IOS Press BV (Amsterdam) 2005;95-100.

Lindner A, Thier P, Haarmeier T, Kircher T, Leube D. Disorders of agency in schizophrenia correlate with an inability to compensate for the sensory consequences of actions. Current Biol; 2005;15:1119-1124

Rucci M, Casile A. Decorrelation of neural activity during fixational eye movements: Possible implications for the refinement of V1 receptive fields. Visual Neuroscience 2005. In press.

Rucci M, Casile A. Fixational instability and natural image statistics: implications for early visual representations, Network 2005;16:121-138

Schwarz C, Horowski A, Möck M, Thier P. Organization of tectopontine fibers within the pontine nuclei of the rat and their spatial relationship to terminals from the visual and somatosensory cortex. J Comp Neurol 2005;484:283-298

Thier P, Ilg UJ. The neural basis of smooth-pursuit eye movements. Curr Op in Neurobiol 2005;15:645-652

2004

Dicke PW, Barash S, Ilg UJ, Thier P. Single-neuron evidence for a contribution of the dorsal nuclei to both types of goal-directed eye movements, saccades and smooth-pursuit. Eur J Neurosci 2004;19:609-624

Golla H, Ignashchenkova A, Haarmeier T, Thier P. Improvement of visual acuity by spatial cueing in human and non-human primates. Vision Res 2004;44:1589-1600

Ignashchenkova A, Dicke PW, Haarmeier T, Thier P. Neuron specific contribution of the superior colliculus to overt and covert shifts of attention. Nat Neurosci 2004;7:56-64

Ignashchenkova A, Haarmeier T, Thier P. The role of the superior colliculus in covert shifts of attention. In: Ilg UJ, Bülthoff H, Mallot H (eds). Dynamic Perception. AKA Akad. Verlag, Berlin, 2004;95-100

Ilg UJ, Schumann S, Thier P. Posterior parietal cortex neurons encode target motion in world-centered coordinates. Neuron 2004;43:145-151

Linnemann C, Sultan F, Pedroarena CM, Schwarz C, Thier P. Lurcher mice exhibit potentiation of GABAA-receptor-mediated conductance in cerebellar nuclei neurons in close temporal relationship to Purkinje cell death. J Neurophysiol 2004;91:1102-1107

Tikhonov A, Haarmeier T, Thier P, Braun C, Lutzenberger W. Neuromagnetic acitivity in medial parieto-occipital cortex reflects the perception of visual motion during eye movements. Neuroimage 2004;21:593-600

2003

Casile A, Giese M. Roles of motion and form in biological motion recognition. In: Kaynak O, Alpaydin E, Oja E, Xu L (eds.) Artifical Networks and Neural Information Processing. Lecture Notes in Computer Science 2714, 2003;854-862

Ilg UJ, Thier P. Visual tracking neurons in primate area MST are activated during smooth pursuit eye movements towards an "imaginary" target. J Neurophysiol 2003;90:1489-1502

Ilg U, Thier P. Zielgerichtete Augenbewegungen. In: Karnath H-O, Thier P (eds.). Neuropsychologie. Springer-Verlag, Heidelberg, 2003;311-324

Sultan F, Czubayko U, Thier P. Morphological classification of the rat cerebellar nuclei neurons by principal component analysis. J Comp Neurol 2003;455:139-155

Thier P. Die funktionelle Architektur des präfrontalen Kortex. In: Karnath H-O, Thier P (eds.). Neuropsychologie. Springer-Verlag, Heidelberg, 2003;495-504

Thier P. Grundlagen zielgerichteter Motorik. In: Karnath H-O, Thier P (eds.). Neuropsychologie. Springer-Verlag, Heidelberg, 2003;285-298.

Thier P. Visuelle Wahrnehmung. In: Karnath H-O, Thier P (eds.). Neuropsychologie. Springer-Verlag, Heidelberg, 2003;531-540

2002

Möck M, Schwarz C, Thier P (2002) Serotonergic control of cerebellar mossy fiber activity by modulation of signal transfer by rat pontine nuclei neurons. Journal of Neurophysiology 88: 549-564

Sultan F, König T, Möck M, Thier P (2002) Quantitative organization of neurotransmitters in the deep cerebellar nuclei of the Lurcher mutant. Journal of Comparative Neurology 452: 311-323

Thier P, Haarmeier T, Ignashchenkova A (2002) The functional architecture of attention. Current Biology 12: 158-162

Thier P, Dicke PW, Haas R, Thielert C-D, Catz N (2002) The role of the oculomotor vermis in the control of saccadic eye movements. Ann NY Acad Sci 978: 50-62

Thier P, Haarmeier T, Chakraborty S, Lindner A, Tikhonov A (2002) Cortical substrates of visuospatial awareness outside the classical dorsal stream of visual processing. In: Cognitive and Neural Bases of Spatial Neglect. Karnath, H.-O. et al. (Eds.) Oxford University Press, pp 71-84

2001

Czubayko U, Sultan F, Thier P, Schwarz C (2001). Two types of neurons in the rat cerebellar nuclei as distinguished by membrane potentials and intracellular fillings. Journal of Neurophysiology 85: 2017-2029

Haarmeier T, Bunjes F, Lindner A, Berret E, Thier P (2001). Optimizing visual motion perception during eye movements. Neuron 32: 527-535

Li W, Thier P, Wehrhahn C (2001) Direct responses from beyond the classical receptive field in V1 of alert monkeys. Experimental Brain Research 139: 359-371

Thier P, Haarmeier T, Chakraborty S, Lindner A, Tikhonov A (2001). Cortical substrates of perceptual stability during eye movements. NeuroImage 14: S33-S39

2000

Haarmeier T, Thier P (2000). Langsame Augenfolgebewegungen und optokinetischer Reflex. Klin Neurophysiol 31: 224-232

Li W, Thier P, Wehrhahn C (2000) Contextual influence on orientiation discrimination of humans and responses of neurons in V1 of alert monkeys. J Neurophysiol 83: 941-954

Salinas E, Thier P (2000) Gain modulation – a major computational principle of the central nervous system. Neuron 27: 15-21

Schwarz C, Thier P (2000) Binding of signals relevant for action. Towards a hypothesis of the functional role of the pontine nuclei. Reply to Bjaalie and Leergard. Trends in Neuroscience 23: 152-153

Sultan F, Möck M, Thier P (2000) Functional architecture of the cerebellar system. In: Neurological Ataxia (ed. Klockgether, T.), Marcel Dekker, New York, 1-52

Thier P, Dicke PW, Haas R, Barash S (2000) Encoding of movement time by populations of cerebellar Purkinje cells. Nature 405: 72-76

Thier P (2000) Ataxia due to acquired vitamin deficiency or metabolic disorder. In: Neurological Ataxia (ed. Klockgether, T.), Marcel Dekker, New York, 633-648

  • Prof. Dr. Shabtai Barash (Weizmann Institute of Science, Rehovot, Israel)      
  • Prof. Dr. Tadashi Isa (National Institute for Physiological Sciences, Okasaki, Japan)
  • Prof. Dr. Erik de Schutter (Okinawa Institute of science and Technology, Okinawa, Japan)
  • Prof. Dr. Reza Shadmehr (Johns Hopkins University, Baltimore, USA)
Leitung Forschungsgruppe
Prof. Dr. Hans-Peter ThierTelefon 07071 29-83057thier@uni-tuebingen.deAnschrift

Hertie-Zentrum für Neurologie
Hertie-Institut für klinische Hirnforschung

Otfried-Müller-Straße 27
72076 Tübingen


Tel.: +49 (0)7071 29-83057
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