Systems Neurophysiology Lab

Associative coupling in the neocortex

 

The overarching goal of our work is to understand the operating principles of the neocortex, a unique brain structure, which mainly evolved in mammals. There is clear evidence that the neocortex, in the broadest sense, endows the subject with cognitive capabilities. The big mystery is, how the vast diversity of neocortex-dependent behaviors are generated by a structure that shows nearly identical neural architecture across species (mouse, rat, monkey, human) and functional systems (sensory, motor, cognition)… more information

Research Projects
Members
Publications
Doctoral and Master Theses

Cellular mechanisms of cerebellar nuclei neurons function

Project leader: Dr. Christine Pedroarena

The basic cerebellar circuit is highly conserved along phylogeny, particularly amongst mammals. On the other hand the large increase in cerebellar size along phylogeny suggests that larger numbers of the same modules provide an increased cerebellar capacity to support the increased complexity of brain functions and expansion of other brain areas. Therefore, the investigations of the basic modular cerebellar circuits carried out in rodents provide useful insights about the human cerebellar function (or dysfunction). The most recognized function of the cerebellum is sensorimotor coordination and its adaptation to environmental changes. This role is illustrated by the severe incoordination of movements and impaired capacity to learn new motor tasks in most forms of cerebellar disease. More recently, a possible role of cerebellum in cognitive functions has been proposed, an idea supported by the involvement of cerebellum in cognitive deficits syndromes, such as autistic disorders.

Our research is focused on the neurons of the deep cerebellar nuclei (DCN). The axons of these cells provide the output pathways of cerebellum and thus are the signals of these cells that ultimately exert the cerebellar control on target structures. Deep cerebellar nuclei neurons are spared in many cerebellar diseases or their function is altered only secondarily to the alterations occurring at the cerebellar cortex. Hence, cerebellar nuclei are a natural place for compensatory mechanisms for diseases affecting the cerebellar cortex. We investigate the cellular mechanisms (synaptic and membrane properties) determining cerebellar nuclei neurons output and its plastic changes and how these might be affected by cerebellar disease, or can be modulated by external agents, with the goal to ultimately understand cerebellar function and provide rational basis for new therapies.

To this end we use in vitro electrophysiological patch recordings and microstimulation combined with optogenetics in brain slices taken from wild type or transgenic animals and immuno-histochemistry staining techniques.


 
Name
Department
Phone
Email
Dr. Alia Benali
Dr. Alia Benali PostDoc
Systems Neurophysiology Lab
07071 29-89033 
Dr. Arindam Bhattacharjee
Dr. Arindam Bhattacharjee PostDoc
Systems Neurophysiology Lab
88900 
Dr. Shubhodeep Chakrabarti
Dr. Shubhodeep Chakrabarti PostDoc
Systems Neurophysiology Lab
07071 29-89033 
 Julian Hofmann
Julian Hofmann PhD Student
Systems Neurophysiology Lab
07071 29-88900 
 Bingshuo Li
Bingshuo Li PhD Student
Systems Neurophysiology Lab
07071 29-89029 
 Maysam Oladazimi
Maysam Oladazimi PhD Student
Systems Neurophysiology Lab
07071 29-89029 
 Ursula Pascht
Ursula Pascht Technical Assistant
Systems Neurophysiology Lab
07071 29-89025 
Dr. Christine Pedroarena
Dr. Christine Pedroarena PostDoc
Systems Neurophysiology Lab
07071 29-87602 
Prof. Dr. Cornelius Schwarz
Prof. Dr. Cornelius Schwarz Research Group Leader
Systems Neurophysiology Lab
07071 29-80462 
 May Li Silva Prieto
May Li Silva Prieto PhD Student
Systems Neurophysiology Lab
07071 29-88900 

2016

Schwarz C (2016) The slip hypothesis: Tactile perception and its neuronal bases. Trends in Neurosciences 39(7): 449-462. doi: 10.1016/j.tins.2016.04.008.

 

2015

Chakrabarti S, Schwarz C (2015) The rodent vibrissal system as a model to study motor cortex function. In: Sensorimotor Integration in the Whisker System. Krieger P, Groh A (eds), Springer, New York, pp 129-148

Chakrabarti S, Schwarz S (2015) Whisking control by motor cortex. Journal of Scholarpedia 10(3):7466

Joachimsthaler B, Brugger D, Skodras A, Schwarz C (2015) Spine loss in primary somatosensory cortex during trace eyeblink conditioning Journal of Neuroscience 35:3772-3781

Schwarz C (2015) Monosynaptic retrograde tracing starts to close the gaps in our understanding of complex premotor networks (Commentary on Sreenivasan et al.). European Journal of Neuroscience 41:352-353

Smith JB, Watson GD, Alloway KD, Schwarz C, Chakrabarti S (2015) Corticofugal projection patterns across the whisker representations to the sensory trigeminal nuclei. Frontiers in Neural Circuits 9:53. doi: 10.3389/fncir.2015.00053. eCollection 2015.

Waiblinger C, Brugger D, Schwarz C (2015) Vibrotactile discrimination in the rat whisker system is based on neuronal coding of instantaneous kinematic cues. Cerebral Cortex 25:1093-1106

Waiblinger C, Brugger D, Whitmire CJ, Stanley GB, Schwarz C (2015) Support for the slip hypothesis from whisker-related tactile perception of rats in a noisy environment. Front Integr Neurosci 2015 Oct 15;9:53. doi: 10.3389/fnint.2015.00053.

 

2014

Chakrabarti, S., Schwarz, C. (2014) Studying motor cortex function using the rodent vibrissal system. e-Neuroforum 5:20-27. doi: 10.1007/s13295-014-0051-y

Georgieva, P., Brugger, D. and Schwarz, C. (2014) Are spatial frequency cues used for whisker-based active discrimination? Front.Behav.Neurosci. 8:379. doi: 10.3389/fnbeh.2014.00379

 

2013

Feldmeyer, D., Brecht, M., Helmchen, F., Petersen, C.C.H., Poulet, J., Staiger, J., Luhmann, H., Schwarz C. (2013) Barrel cortex function. Progress in Neurobiology 103: 3–27

Gerdjikov T.V., Haiss F., Rodriguez-Sierra O., Schwarz C. (2013) Rhythmic whisking area (RW) in rat primary motor cortex: an internal monitor of movement-related signals? J Neurosci 33:14193–14204

Theis, L., Chagas, A.M. Arnstein, D., Schwarz, C., Bethge, M. (2013) Beyond GLMs: A generative mixture modeling approach to neural system identification. PLOS Comp. Biol., 9:e1003356. doi: 10.1371/journal.pcbi.1003356

Chagas, A.M.; Theis, L., Sengupta, B., Stüttgen, M.C., Bethge, M., Schwarz, C. (2013) Functional analysis of ultra high information rates conveyed by rat vibrissal primary afferents. Front. Neural Circuits 7:190. doi: 10.3389/fncir.2013.00190

 

2012

Quadrato G, Benevento M, Alber S, Jacob C, Floriddia EM, Nguyen T, Elnaggar MY, Pedroarena CM, Molkentin JD and Di Giovanni S. (2012). Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus. Proc Natl Acad Sci USA 109:E1499-1508

 

2011

Pedroarena CM (2011) BK and Kv3.1 Potassium Channels Control Different Aspects of Deep Cerebellar Nuclear Neurons Action Potentials and Spiking Activity. Cerebellum. 2011 Jul 13. [Epub ahead of print]. DOI:10.1007/s12311-011-0279-9

Braun, C., Eisele, E, Wühle, A., Stüttgen, M., Schwarz, C., Demarchi G. (2011) Mislocalization of near-threshold tactile stimuli in humans: a central or peripheral phenomenon. Eur. J. Neurosci., 33:499-508

Brugger, D., Butovas, S., Bogdan, M., Schwarz, C. (2011) Real-time adaptive microstimulation increases reliability of electrically evoked cortical potentials. IEEE Trans. Biomed. Eng., 58: 1483-1491

Stüttgen, M.C., Schwarz, C., Jäkel, F. (2011) Mapping spikes to sensations. Front.Neurosci. 5:125 

 

2010

Belmeguenai A, Hosy E, Bengtsson F, Pedroarena C, Teuling CPE, He Q, Ohtsuki G, De Jeu MTG, Elgersma Y, De Zeeuw CI, Jörntel H, Hansel C (2010) Intrinsic plasticity complements LTP in parallel fiber input gain control in cerebellar Purkinje cells. J Neurosci 30(41):13630-13643

Schwarz, C. (2010) The fate of spontaneous synchronous rhythms on the cerebro-cerebellar loop. Cerebellum 9:77-87 

Stüttgen M.C. and Schwarz C. (2010) Integration of vibrotactile signals for whisker-related perception in rats is governed by short time constants: comparison of neurometric and psychometric detection performance. J. Neurosci. 30:2060-2069.

Haiss, F., Butovas, S., Schwarz, C. (2010) A miniaturized chronic microelectrode drive for awake behaving head restrained mice and rats. J. Neurosci. Meth., 187:67-72

Gerdjikov, T.V., Bergner, C.G., Stüttgen, M.C., Waiblinger, C., Schwarz, C. (2010) Discrimination of vibrotactile stimuli in the rat whisker system - behavior and neurometrics. Neuron, 65:530-540

Butovas, S., Rudolph, U., Jurd, R., Schwarz, C., Antkowiak, B. (2010) Activity patterns in the prefrontal cortex and hippocampus during and after awakening from etomidate anesthesia. Anesthesiology, 113:48-57

Schwarz, C., Hentschke, H., Butovas, S., Haiss, F., Stüttgen, M.C., Gerdjikov, T.V., Bergner, C.G. Waiblinger, C. (2010) The head-fixed behaving rat – procedures and pitfalls. Somatosensory & Motor Research, 27:131-48

Kreuzer, M., Hentschke, H., Antkowiak, B., Schwarz, C., Kochs, E.F., Schneider, G. (2010) Cross-Approximate Entropy of cortical local field potentials quantifies effects of anesthesia - a pilot study in rats. BMC Neuroscience, 11:122

 

Weitere Publikationen finden sie unter:

http://orcid.org/0000-0003-4725-473X

http://orcid.org/0000-0001-9713-0538

http://orcid.org/0000-0001-9713-0538

Ongoing dissertation work

 

André Maia Chagas (GSNBS)
Supervisor Prof. Dr. C. Schwarz

Julian Hofmann (GSNBS)
Supervisor Prof. Dr. C. Schwarz

Maysam Oladazimi (GSNBS)
Supervisor Prof. Dr. C. Schwarz

Bingshuo Li (GSNBS)
Supervisor Prof. Dr. C. Schwarz / Prof. Dr. U. Ziemann

 

Completed dissertations (since 2000)

 

Christian Waiblinger (2015)
The role of kinematic events in whisker-related tactile perception
Prof. Dr. C. Schwarz

Petya Georgieva (2014)
Active perception of virtual texture frequency in the whisker-related sensorimotor system of the rat
Prof. Dr. C. Schwarz

Bettina Joachimsthaler (2014)
Two photon imaging of structural plasticity underlying classical eyeblink conditioning in mouse barrel cortex
Prof. Dr. C. Schwarz

Caroline Bergner (2012)
Neuronal correlates of frequency discrimination in the tactile system
Prof. Dr. C. Schwarz

Isabella Schmeh (2012)
Gene expression of potential modulators of inhibitory neurotransmission in the Lurcher mutant mouse
Prof. Dr. C. Schwarz

Dominik Brugger (2009)
Adaptive microstimulation for stabilizing evoked cortical potentials
Prof. Dr. C. Schwarz

Florent Haiss (2007)
Contributions of motor areas to sensory processing during active and passive touch
Prof. Dr. C. Schwarz

Maik Stüttgen (2007)
Psychophysical channels and the physiology of perception in the rat whisker system
Betreuer Prof. Dr. C. Schwarz

Sergejus Butovas (2007)
Local synaptic effects of microstimulation in barrel cortex and pontine nuclei in the rat
Prof. Dr. C. Schwarz

Susanne Kamphausen (2006)
Functional architecture of the cerebellar nuclei: Investigations of membrane physiology, morphology, and glycinergic synaptic transmission of cerebellar nuclei neurons
Prof. Dr. C. Schwarz 

Anja Horowski (2002)
Organization of tectopontine axon terminals with respect to the projections from visual and somatosensory cortices and dendritic fields of pontine projection neurons: Compartmentalization of rat pontine nuclei
Prof. Dr. P. Thier, Prof. Dr. C. Schwarz

Uwe Czubayko (2000)
A characterization of neuronal types in rat cerebellar nuclei using electrophysiological and morphological properties
Prof. Dr. P. Thier, Prof. Dr. C. Schwarz

Research Group Leader
Prof. Cornelius Schwarz cornelius.schwarz(at)uni-tuebingen.de Address

Center of Neurology
Hertie Institute for Clinical Brain Research 
Department Cognitive Neurology

Otfried-Müller-Straße 25
72076 Tübingen

Phone: +49 (0)7071 29-80462
Fax: +49 (0)7071 29-25011