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Genetics of Parkinson's disease

Analysis of genetic factors in hereditary and non-hereditary forms of Parkinson's disease

 

Parkinson's syndrome (PS) is the second most common neurodegenerative disease after Alzheimer's dementia. The vast majority of patients are ill with no apparent cause. In a small part of the patients (less than 5%) a clear heredity can be observed. Despite their rarity, the identification and functional analysis of the genes leading to these so-called "monogenic" forms of the disease has contributed significantly to the elucidation of the cellular mechanisms involved in disease development. It is assumed that so far only a small fraction of the causative genes has been found. However, the causes of the far more frequent non-hereditary forms of Parkinson's disease are still unknown. It is also assumed for this probably heterogeneous group of diseases that genetic factors play a not insignificant role, especially in the sense of influencing the risk of illness, the age of onset or the course of the disease. The first group of genome-wide association studies (GWAS) has already shown that variants in several genes, which have already been described as disease-related in familial forms of the disease, can also influence the risk for non-hereditary disease forms.

 

 

Research projects
Members
Publications
Theses

Genetic causes of the sporadic Parkinson's disease

 

 The genetic variants known today can only explain a small part of the overall risk of disease. In order to obtain a more complete picture of the entire genetic risk profile and to derive new approaches for diagnosis, prevention or therapy, as complete genetic data sets as possible must be examined by many thousands of patients. In large international consortia, such as the International Parkinson's Disease Genomics Consortium (IPDGC), the research group conducts such studies in collaboration with many colleagues from around the world (Simon-Sanchez et al., Nat Genet, 2009, Nalls et al., Nat Genet 2014).

Contact: Prof. Dr. T. Gasser, Prof. D. Berg

Leucine rich repeat kinase 2, LRRK2 (Park8)

 

In 2004, the group was able to identify mutations in the LRRK2 gene (Leucine rich repeats kinase 2) in two large families with inherited Parkinson's disease (Zimprich et al., Neuron 2004). This discovery was taken up by many other groups around the world, and it turned out that LRRK2 mutations are the most common cause for autosomal dominant Parkinson's syndrome. Although all patients from affected families have mutations in the same gene, there is a remarkable heterogeneity both in terms of clinical appearance and neuropathological findings. For example, the spectrum of found protein aggregates of typical Lewy corpuscles or tau-positive neurofibrils suffices to the complete absence of both aggregate forms. The elucidation of the molecular pathomechanism of the disease caused by LRRK2 mutations could therefore be important for synucleinopathies (Lewy corpuscles) as well as for tauopathies (neurofibrils). This suggests a central role of the gene product in the pathogenesis of various neurodegenerative diseases with Parkinson's disease.

Contact: Prof. Dr. T. Gasser

 

Courage-PD: COmprehensive Unbiased Risk factor Assessement for Genetics and Environment in Parkinson‘s Disease

 

This multi-national project, funded under the "Joint Programming for Neurodegenerative Disease (JPND)", will combine genetic, epidemiological and cell biology approaches to contribute to a better understanding of the development of Parkinson's disease. Particular attention is paid to the interaction of genetic and environmental factors in the development of the disease. Risk factors are then examined in cell culture models based on the iPS (induced pluripotent stem cells) technology for their functional effects.

Contact: Prof. Dr. T. Gasser, Prof. Dr. R. Krüger, Dr. M. Sharma


 
Name
Department
Phone
Email
 Burcu Atasu
Burcu Atasu
Parkinson Genetics
 
 Saskia Biskup
Saskia Biskup
Parkinson Genetics
 
Dr. Kathrin Brockmann
Dr. Kathrin Brockmann Physician, Provisional Research Group Leader
Clinical Parkinsons Disease Research
 
nicht löschen! Christine Bus
nicht löschen! Christine Bus PhD Student
PD Stem Cells
07071 29-87608 
 Silvia De Cicco
Silvia De Cicco
PD Stem Cells
07071 29-881969 
 Mohammad Dehestani
Mohammad Dehestani
Parkinson Genetics
 
 Michela Deleidi
Michela Deleidi
Parkinson Genetics
07071 29-87608 
 Christian Erhardt
Christian Erhardt
Parkinson Genetics
07071 29-87610 
 Natalja Funk
Natalja Funk
Parkinson Genetics
 
Prof. Dr. Thomas Gasser
Prof. Dr. Thomas Gasser Head of Department
Parkinson Genetics
07071 29-86529 
 Ann-Kathrin Hauser
Ann-Kathrin Hauser
Parkinson Genetics
07071 29-82041 
 Susanna Hoffmann
Susanna Hoffmann
Parkinson Genetics
07071 29-87608 
 Dina Ivanyuk
Dina Ivanyuk
PD Stem Cells
 
 Felix Knab
Felix Knab
Parkinson Genetics
 
 Hui Liu
Hui Liu
Parkinson Genetics
 
Dr. Gerrit Machetanz
Dr. Gerrit Machetanz Physician
Parkinson Genetics
 
 Petra Mech
Petra Mech
Parkinson Genetics
07071 29-87640 
 Angelika Oehmig
Angelika Oehmig
Parkinson Genetics
07071 29-81978 
 Vasiliki Panagiotakopoulou
Vasiliki Panagiotakopoulou
Parkinson Genetics
 
 Miriam Peleman
Miriam Peleman
Parkinson Genetics
07071 29-81977 
 Benjamin Riebenbauer
Benjamin Riebenbauer
Parkinson Genetics
07071 29-82041 
 Claudia Schulte
Claudia Schulte PhD Student
Clinical Parkinsons Disease Research
07071 29-82041 
 Manu Sharma
Manu Sharma
Parkinson Genetics
 

 

2015 

 

Desikan, R. S., A. J. Schork, Y. Wang, A. Witoelar, M. Sharma, L. K. McEvoy, D. Holland, J. B. Brewer, C. H. Chen, W. K. Thompson, D. Harold, J. Williams, M. J. Owen, M. C. O'Donovan, M. A. Pericak-Vance, R. Mayeux, J. L. Haines, L. A. Farrer, G. D. Schellenberg, P. Heutink, A. B. Singleton, A. Brice, N. W. Wood, J. Hardy, M. Martinez, S. H. Choi, A. DeStefano, M. A. Ikram, J. C. Bis, A. Smith, A. L. Fitzpatrick, L. Launer, C. van Duijn, S. Seshadri, I. D. Ulstein, D. Aarsland, T. Fladby, S. Djurovic, B. T. Hyman, J. Snaedal, H. Stefansson, K. Stefansson, T. Gasser, O. A. Andreassen and A. M. Dale (2015). "Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus." Mol Psychiatry.

Escott-Price, V., C. International Parkinson's Disease Genomics, M. A. Nalls, H. R. Morris, S. Lubbe, A. Brice, T. Gasser, P. Heutink, N. W. Wood, J. Hardy, A. B. Singleton, N. M. Williams and I. c. members (2015). "Polygenic risk of Parkinson disease is correlated with disease age at onset." Ann Neurol 77(4): 582-591.

Gasser, T. (2015). "Usefulness of Genetic Testing in PD and PD Trials: A Balanced Review." J Parkinsons Dis.

Nalls, M. A., J. Bras, D. G. Hernandez, M. F. Keller, E. Majounie, A. E. Renton, M. Saad, I. Jansen, R. Guerreiro, S. Lubbe, V. Plagnol, J. R. Gibbs, C. Schulte, N. Pankratz, M. Sutherland, L. Bertram, C. M. Lill, A. L. DeStefano, T. Faroud, N. Eriksson, J. Y. Tung, C. Edsall, N. Nichols, J. Brooks, S. Arepalli, H. Pliner, C. Letson, P. Heutink, M. Martinez, T. Gasser, B. J. Traynor, N. Wood, J. Hardy, A. B. Singleton, C. International Parkinson's Disease Genomics and c. Parkinson's Disease meta-analysis (2015). "NeuroX, a fast and efficient genotyping platform for investigation of neurodegenerative diseases." Neurobiol Aging 36(3): 1605 e1607-1612.

Simon-Sanchez, J. and T. Gasser (2015). "Parkinson disease GWAS: the question of lumping or splitting is back again." Neurology 84(10): 966-967.

2014

 

Mencacci, N. E., I. U. Isaias, M. M. Reich, C. Ganos, V. Plagnol, J. M. Polke, J. Bras, J. Hersheson, M. Stamelou, A. M. Pittman, A. J. Noyce, K. Y. Mok, T. Opladen, E. Kunstmann, S. Hodecker, A. Munchau, J. Volkmann, S. Samnick, K. Sidle, T. Nanji, M. G. Sweeney, H. Houlden, A. Batla, A. L. Zecchinelli, G. Pezzoli, G. Marotta, A. Lees, P. Alegria, P. Krack, F. Cormier-Dequaire, S. Lesage, A. Brice, P. Heutink, T. Gasser, S. J. Lubbe, H. R. Morris, P. Taba, S. Koks, E. Majounie, J. Raphael Gibbs, A. Singleton, J. Hardy, S. Klebe, K. P. Bhatia, N. W. Wood, C. International Parkinson's Disease Genomics and U. C.-e. consortium (2014). "Parkinson's disease in GTP cyclohydrolase 1 mutation carriers." Brain 137(Pt 9): 2480-2492.

Nalls, M. A., N. Pankratz, C. M. Lill, C. B. Do, D. G. Hernandez, M. Saad, A. L. DeStefano, E. Kara, J. Bras, M. Sharma, C. Schulte, M. F. Keller, S. Arepalli, C. Letson, C. Edsall, H. Stefansson, X. Liu, H. Pliner, J. H. Lee, R. Cheng, C. International Parkinson's Disease Genomics, G. I. Parkinson's Study Group Parkinson's Research: The Organized, andMe, GenePd, C. NeuroGenetics Research, G. Hussman Institute of Human, I. The Ashkenazi Jewish Dataset, H. Cohorts for, E. Aging Research in Genetic, C. North American Brain Expression, C. United Kingdom Brain Expression, C. Greek Parkinson's Disease, G. Alzheimer Genetic Analysis, M. A. Ikram, J. P. Ioannidis, G. M. Hadjigeorgiou, J. C. Bis, M. Martinez, J. S. Perlmutter, A. Goate, K. Marder, B. Fiske, M. Sutherland, G. Xiromerisiou, R. H. Myers, L. N. Clark, K. Stefansson, J. A. Hardy, P. Heutink, H. Chen, N. W. Wood, H. Houlden, H. Payami, A. Brice, W. K. Scott, T. Gasser, L. Bertram, N. Eriksson, T. Foroud and A. B. Singleton (2014). "Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease." Nat Genet.

Schondorf, D. C., M. Aureli, F. E. McAllister, C. J. Hindley, F. Mayer, B. Schmid, S. P. Sardi, M. Valsecchi, S. Hoffmann, L. K. Schwarz, U. Hedrich, D. Berg, L. S. Shihabuddin, J. Hu, J. Pruszak, S. P. Gygi, S. Sonnino, T. Gasser and M. Deleidi (2014). "iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis." Nat Commun 5: 4028.

2013

 

Engeholm, M. and T. Gasser (2013). "Parkinson's disease: is it all in the genes?" Mov Disord 28(8): 1027-1029.

Nalls, M. A., R. Duran, G. Lopez, M. Kurzawa-Akanbi, I. G. McKeith, P. F. Chinnery, C. M. Morris, J. Theuns, D. Crosiers, P. Cras, S. Engelborghs, P. P. De Deyn, C. Van Broeckhoven, D. M. Mann, J. Snowden, S. Pickering-Brown, N. Halliwell, Y. Davidson, L. Gibbons, J. Harris, U. M. Sheerin, J. Bras, J. Hardy, L. Clark, K. Marder, L. S. Honig, D. Berg, W. Maetzler, K. Brockmann, T. Gasser, F. Novellino, A. Quattrone, G. Annesi, E. V. De Marco, E. Rogaeva, M. Masellis, S. E. Black, J. M. Bilbao, T. Foroud, B. Ghetti, W. C. Nichols, N. Pankratz, G. Halliday, S. Lesage, S. Klebe, A. Durr, C. Duyckaerts, A. Brice, B. I. Giasson, J. Q. Trojanowski, H. I. Hurtig, N. Tayebi, C. Landazabal, M. A. Knight, M. Keller, A. B. Singleton, T. G. Wolfsberg and E. Sidransky (2013). "A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies." JAMA Neurol 70(6): 727-735.

Nalls, M. A., M. Saad, A. J. Noyce, M. F. Keller, A. Schrag, J. P. Bestwick, B. J. Traynor, J. R. Gibbs, D. G. Hernandez, M. R. Cookson, H. R. Morris, N. Williams, T. Gasser, P. Heutink, N. Wood, J. Hardy, M. Martinez and A. B. Singleton (2013). "Genetic comorbidities in Parkinson's disease." Hum Mol Genet.

Reinhardt, P., B. Schmid, L. F. Burbulla, D. C. Schondorf, L. Wagner, M. Glatza, S. Hoing, G. Hargus, S. A. Heck, A. Dhingra, G. Wu, S. Muller, K. Brockmann, T. Kluba, M. Maisel, R. Kruger, D. Berg, Y. Tsytsyura, C. S. Thiel, O. E. Psathaki, J. Klingauf, T. Kuhlmann, M. Klewin, H. Muller, T. Gasser, H. R. Scholer and J. Sterneckert (2013). "Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression." Cell Stem Cell 12(3): 354-367.

Sharma, M., R. Kruger and T. Gasser (2013). "From Genome-Wide Association Studies to Next-Generation Sequencing: Lessons From the Past and Planning for the Future." JAMA Neurol. 

2012

 

Biskup, S. and T. Gasser (2012). "Genetic testing in neurological diseases." J Neurol 259(6): 1249-1254.

Holmans, P., V. Moskvina, L. Jones, M. Sharma, A. Vedernikov, F. Buchel, M. Sadd, J. M. Bras, F. Bettella, N. Nicolaou, J. Simon-Sanchez, F. Mittag, J. R. Gibbs, C. Schulte, A. Durr, R. Guerreiro, D. Hernandez, A. Brice, H. Stefansson, K. Majamaa, T. Gasser, P. Heutink, N. W. Wood, M. Martinez, A. B. Singleton, M. A. Nalls, J. Hardy, H. R. Morris and N. M. Williams (2012). "A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease." Hum Mol Genet.

Keller, M. F., M. Saad, J. Bras, F. Bettella, N. Nicolaou, J. Simon-Sanchez, F. Mittag, F. Buchel, M. Sharma, J. R. Gibbs, C. Schulte, V. Moskvina, A. Durr, P. Holmans, L. L. Kilarski, R. Guerreiro, D. G. Hernandez, A. Brice, P. Ylikotila, H. Stefansson, K. Majamaa, H. R. Morris, N. Williams, T. Gasser, P. Heutink, N. W. Wood, J. Hardy, M. Martinez, A. B. Singleton and M. A. Nalls (2012). "Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease." Hum Mol Genet 21(22): 4996-5009.

Sharma, M., J. P. A. Ioannidis, J. O. Aasly, G. Annesi, A. Brice, C. Van Broeckhoven, L. Bertram, M. Bozi, D. Crosiers, C. Clarke, M. Facheris, M. Farrer, G. Garraux, S. Gispert, G. Auburger, C. Vilarino-Guell, G. M. Hadjigeorgiou, A. A. Hicks, N. Hattori, B. Jeon, S. Lesage, C. M. Lill, J. J. Lin, T. Lynch, P. Lichtner, A. E. Lang, V. Mok, B. Jasinska-Myga, G. D. Mellick, K. E. Morrison, G. Opala, P. P. Pramstaller, I. Pichler, S. S. Park, A. Quattrone, E. Rogaeva, O. A. Ross, L. Stefanis, J. D. Stockton, W. Satake, P. A. Silburn, J. Theuns, E. K. Tan, T. Toda, H. Tomiyama, R. J. Uitti, K. Wirdefeldt, Z. Wszolek, G. Xiromerisiou, K. C. Yueh, Y. Zhao, T. Gasser, D. Maraganore, R. Kruger and G.-P. Consortium (2012). "Large-scale replication and heterogeneity in Parkinson disease genetic loci." Neurology 79(7): 659-667.

2011

 

Brockmann, K., A. Groger, A. Di Santo, I. Liepelt, C. Schulte, U. Klose, W. Maetzler, A. K. Hauser, R. Hilker, B. Gomez-Mancilla, D. Berg and T. Gasser (2011). "Clinical and brain imaging characteristics in leucine-rich repeat kinase 2-associated PD and asymptomatic mutation carriers." Mov Disord.

Brockmann, K., K. Srulijes, A. K. Hauser, C. Schulte, I. Csoti, T. Gasser and D. Berg (2011). "GBA-associated PD presents with nonmotor characteristics." Neurology 77(3): 276-280.

Gasser, T., J. Hardy and Y. Mizuno (2011). "Milestones in PD genetics." Mov Disord 26(6): 1042-1048.

International Parkinson Disease Genomics, C., M. A. Nalls, V. Plagnol, D. G. Hernandez, M. Sharma, U. M. Sheerin, M. Saad, J. Simon-Sanchez, C. Schulte, S. Lesage, S. Sveinbjornsdottir, K. Stefansson, M. Martinez, J. Hardy, P. Heutink, A. Brice, T. Gasser, A. B. Singleton and N. W. Wood (2011). "Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies." Lancet 377(9766): 641-649. 

2010

 

Brockmann, K., A. Groger, A. Di Santo, I. Liepelt, C. Schulte, U. Klose, W. Maetzler, A. K. Hauser, R. Hilker, B. Gomez-Mancilla, D. Berg and T. Gasser (2010). "Clinical and brain imaging characteristics in leucine-rich repeat kinase 2-associated PD and asymptomatic mutation carriers." Mov Disord 26(13): 2335-2342.

Gasser, T. (2010). "Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects." Prog Brain Res 183: 3-20.

2009

 

Original Articles

  

Djarmati A, Hagenah J, Reetz K, Winkler S, Behrens MI, Pawlack H, Lohmann K, Ramirez A, Tadić V, Brüggemann N, Berg D, Siebner HR, Lang AE, Pramstaller PP, Binkofski F, Kostić VS, Volkmann J, Gasser T, Klein C. (2009) ATP13A2 variants in early-onset Parkinson's disease patients and controls. Mov Disord. 2009 Aug 24.

Fuchs J, Mueller JC, Lichtner P, Schulte C, Munz M, Berg D, Wüllner U, Illig T, Sharma M, Gasser T. (2009) The transcription factor PITX3 is associated with sporadic Parkinson's disease. Neurobiol Aging. 2009 May;30(5):731-8.

Klein CL, Rovelli G, Springer W, Schall C, Gasser T, Kahle PJ. (2009) Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment. J Neurochem. 2009 Aug 27.

Rothfuss O, Fischer H, Hasegawa T, Maisel M, Leitner P, Miesel F, Sharma M, Bornemann A, Berg D, Gasser T, Patenge N. (2009) Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair. Hum Mol Genet. 2009 Oct 15;18(20):3832-50.

Scholz SW, Houlden H, Schulte C, Sharma M, Li A, Berg D, Melchers A, Paudel R, Gibbs JR, Simon-Sanchez J, Paisan-Ruiz C, Bras J, Ding J, Chen H, Traynor BJ, Arepalli S, Zonozi RR, Revesz T, Holton J, Wood N, Lees A, Oertel W, Wüllner U, Goldwurm S, Pellecchia MT, Illig T, Riess O, Fernandez HH, Rodriguez RL, Okun MS, Poewe W, Wenning GK, Hardy JA, Singleton AB, Gasser T. (2009) SNCA variants are associated with increased risk for multiple system atrophy. Ann Neurol. 2009 May;65(5):610-4.

Sidransky E, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, Bar-Shira A, Berg D, Bras J, Brice A, Chen C-M, Clark LN, Condroyer C, de Marco EV, Dürr A, Eblan MJ, Fahn S, Farrer M, Fung H-C, Gan-Or Z, Gasser T, Gershoni-Baruch R, Giladi N, Griffith A, Gurevich T, Januario C, Kropp P, Lang AE, Lee-Chen G-J, Lesage S, Marder K, Mata IF, Mirelman A, Mitsui J, Mizuta I, Nalls MA, Nicoletti G, Oliveira C, Ottman R , Orr-Urtreger A, Pereira LV, Quattrone A, Rogaeva E, Rolfs A, Rosenbaum H, Rozenberg R, Samii A, Samaddar T, Schulte C, Sharma M, Singleton S, Spitz M, TanE-K, Tayebi N, Toda T, Troiano A, Tsuji S, Wittstock M, Wolfsberg TG, Wu Y-R, Zabetian CP, Zhao Y, Ziegler SG (2009) International multi-center analysis of glucocerebrosidase mutations in Parkinson disease. New Engl J Med.

Simon-Sanchez J, Schulte C, Bras CM, Sharma M, Gibbs R, Berg D, Paison-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Fedoroff M, Klein C, Goate A, Perlmutter J, Bonin M, Nalls MA, Illig T, Gieger C, Houlden H, Steffens M, Okun MS, Foote KD,  Fernandez HH, Schreiber S, Arepalli S, Zonozi R, Gwinn K, Lopez G, Chanock SJ, Schatzkin A, Park Y, Hollenbeck A, Gao J, Huang X, Wood NW, Lorenz D, Deuschl G, Chen H, Riess O, Hardy JA, Singleton AB, Gasser T.  (2009) Genome-wide association study reveals genetic risk underlying Parkinson’s disease. Nat Genet.

Gasser T. (2009) Genomic and proteomic biomarkers for Parkinson disease. Neurology. 2009 Feb 17;72(7 Suppl):S27-31.

2008

 

Fuchs J, Tichopad A, Golub Y, Munz M, Schweitzer KJ, Wolf B, Berg D, Mueller JC, Gasser T (2008) Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain. The FASEB Journal 22(5):1327-34

Gasser T (2008) Hunting for genes and mutations: it’s worth remembering the basics. Neurology 70(16 Pt 2):1373-4

Healy DG, Falchi M, O’Sullivan SS, Bonifati V, Durr A, Bressman S, Brice A, Aasly J, Zabetian CP, Goldwurm S, Ferreira JJ, Tolosa E, Kay DM, Klein C, Williams DR, Marras C, Lang AE, Wszolek ZK, Berciano J, Schapira AHV, Lynch T, Bhatia KP, Gasser T, Lees AJ, Wood NW (2008) Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson’s disease: a case-control study. Lancet Neurology 7(7):583-90

Prestel J, Gempel K, Hauser T, Schweitzer K, Prokisch H, Ahting U, Freudenstein D, Bueltmann E, Naegele T, Berg D, Klopstock T, Gasser T (2008) Clinical and molecular characterisation of a Parkinson family with a novel PINK1 mutation. Journal of Neurology 255(5):643-8

2007 

 

Fuchs J, Nilsson C, Kachergus J, Munz M, Larsson EM, Schule B, Langston JW, Middleton FA, Ross OA, Hulihan M, Gasser T, Farrer MJ (2007) Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication. Neurology 68(12):916-22

Gasser T (2007) Update on the genetics of Parkinson‘s disease. Movement Disord 22(S17):S343-50

2006

 

Sharma M, Mueller JC, Zimprich A, Lichtner P, Hofer A, Leitner P, Maass S, Berg D, Dürr A, Bonifati V, De Michele G, Oostra B, Brice A, Wood NW, Müller-Myhsok B, Gasser T (2006) The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations. J Med Genet 43:557-62

2005 

 

Berg, D., K. Schweitzer, P. Leitner, A. Zimprich, P. Lichtner, P. Belcredi, T. Brussel, C. Schulte, S. Maass, T. Nagele, E. K. Wszolek and T. Gasser (2005). "Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease*." Brain 128(Pt 12): 3000-3011.

Mueller, J. C., J. Fuchs, A. Hofer, A. Zimprich, P. Lichtner, T. Illig, D. Berg, U. Wullner, T. Meitinger and T. Gasser (2005). "Multiple regions of alpha-synuclein are associated with Parkinson's disease." Ann Neurol 57(4): 535-541.

2004

  

Zimprich, A., S. Biskup, P. Leitner, P. Lichtner, M. Farrer, S. Lincoln, J. Kachergus, M. Hulihan, R. J. Uitti, D. B. Calne, A. J. Stoessl, R. F. Pfeiffer, N. Patenge, I. C. Carbajal, P. Vieregge, F. Asmus, B. Muller-Myhsok, D. W. Dickson, T. Meitinger, T. M. Strom, Z. K. Wszolek and T. Gasser (2004). "Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology." Neuron 44(4): 601-607.

 

Current theses


Scientific theses

 

Claudia Schulte
Untersuchung der genetischen Ursachen des Parkinsonsyndroms
Prof. Dr. T. Gasser

Julia Sekler
Expression von SNCA im Hinblick auf die molekulare Entstehung der Parkinson Krankheit
Prof. Dr. T. Gasser

David Schöndorf
Modeling Parkinson's Disease using genome editing in human induced pluripotent stem cells
Prof. Dr. T. Gasser

Medical theses

  

Norbert Silimon
Untersuchung des Einflusses von SNCA-Rep1 auf das Erkrankungsalter und klinische Parameter bei Patienten mit idiopathischem Parkinson-Syndrom
Prof. Dr. T. Gasser

Steffen Brenner
Genetische Untersuchungen zur α-Synuklein-Expression
Prof. Dr. T. Gasser

 

Completed theses

 

Michela Deleidi
In vitro and in vivo modelling of Parkinson's disease using induced pluripotent stem cells
Prof. Dr. T. Gasser

Benjamin Schmid
Establishment and characterization of a human in vitro cell model for Parkinson’s disease
Prof. Dr. T. Gasser

Marta Garcia-Morales
Cellular phenotypes associated with LRRK2-mutations
Dr. Saskia Biskup

Rebecca Gottorf                                                      
Analyse der relativen Genexpression von LRRK2 und {alpha}-Synuclein in humanem Vollblut mittels
quantitativer real time RT-PCR in einem heterogenen Probandenkollektiv aus Parkinsonpatienten, symptomatischen und symptomatischen LRRK2-Mutationsträgern und Kontrollen
Dr. Saskia Biskup, Dr. Martina Wölfle

Oliver Rothfuss
Funktionelle Charakterisierung des Parkin-Gens
Dr. Nadja Patenge

Manu Sharma
Genetic Epidemiology of Parkinson's Disease: approaches for Gene mapping
Prof. Dr. T. Gasser, Dr. B. Müller-Myhsok

Julia Fuchs
Genetic risk factors and their functional implications in Parkinson’s disesase
Prof. Dr. T. Gasser

Director
Prof. Thomas Gasser thomas.gassermed.uni-tuebingen.de Address

Center of Neurology
Hertie Institute for Clinical Brain Research
Department Neurodegenerative Diseases

Hoppe-Seyler-Straße 3
72076 Tübingen

Phone: +49 (0)7071 29-86529
Fax: +49 (0)7071 29-4839

Office

Isolde Marterer
Phone: +49 (0)7071 29-82048
isolde.marterermed.uni-tuebingen.de

Department Coordination

Dr. Angelika Oehmig
Miriam Peleman
Petra Mech
Otfried-Müller-Straße 27
Phone: +49 (0)7071 29-87640