HIH News

New target for Alzheimer's therapies found

Researchers from Tübingen discover link between the protein medin and Alzheimer's disease

The protein medin is deposited in the blood vessels of the brains of Alzheimer's patients along with the protein amyloid-β. DZNE Researchers have discovered this so-called co-aggregation. They have now published their observation in the renowned journal Nature. "Medin has been known for over 20 years, but its influence on diseases was previously underestimated. We were able to show that pathological changes in the blood vessels of Alzheimer's patients are significantly enhanced by medin," says Dr. Jonas Neher from the Tübingen site of Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), who led the study. The Hertie Institute for Clinical Brain Research in Tübingen, the University of Tübingen and several international institutions and cooperation partners were also involved in this long-term project.


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