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Systems Neurophysiology Lab

Associative coupling in the neocortex

The overarching goal of our work is to understand the operating principles of the neocortex, a unique brain structure, which mainly evolved in mammals. There is clear evidence that the neocortex, in the broadest sense, endows the subject with cognitive capabilities. The big mystery is, how the vast diversity of neocortex-dependent behaviors are generated by a structure that shows nearly identical neural architecture across species (mouse, rat, monkey, human) and functional systems (sensory, motor, cognition): The neocortex is a quasi-two dimensional sheet of neural tissue, which is composed of repetitive neuronal elements and network connections. Even an expert can hardly decide on the basis of a microscopic image of neocortex, whether it was prepared from a mouse, rat, monkey or human.

The generality of neuronal architecture related to vastly diverse functions renders it likely that, beyond specific signal processing, there must be a generic function common to all cortical areas in animals and humans. We hypothesize that the neocortex is a giant associative storage device, which handles flexible combinations of sensory, motor and cognitive functions that the individual is learning throughout his/her life.

To verify this hypothesis, we firstly need to clarify how signals are represented within neocortical networks and what role the confusing multitude of neuronal components plays (e. g. the six neocortical layers, or the various types of excitatory and inhibitory neurons). Second, it must be resolved how separate areas are linked and whether the link and concurrent signal processing make use of the same neural elements and activities, or whether they can be separated.

This research therefore requires the combination of a macroscopic and microscopic view – i. e. the study of representation of memories on the cellular level locally and their linkage between cortical areas globally. We employ an integrative approach using modern methods of multiple neuron electrophysiology and optical imaging and combine it with behavioral observation at highest precision. For that purpose we aim at highly quantitative analysis and representation of our results, reflected by cooperative work with computational neuroscientists. Our model of choice for studying these questions is the sensorimotor vibrissal system (vibrissae = whiskers) of rodents. These animals use an ‘active’ strategy of sampling tactile information about their immediate environment by actively moving their vibrissae across objects in their vicinity. We examine tactile representations, how they are formed into a percept, and how they are coupled to motor representations to optimize tactile exploration. We have begun to also study coupling of other areas, e. g. sensory and so-called higher cortical areas, during decision making. Finally, we have set up a learning paradigm, the so-called trace eye blink conditioning using whisker-related tactile signals as conditioned stimuli, to study how new learned contents is stored in cortical networks.

Regarding the close similarity of neocortex in animals and humans it is very likely that basic scientific knowledge that we gain in animals can be generalized very easily to understand also principles of function or dysfunction in humans and patients. Of course, future applications for the better of humans suffering from neocortical diseases such as Alzheimer’s and Parkinson’s disease, schizophrenia, or depression, need future progress in applied and translational neuroscience. However, before this can happen, a thorough understanding of the bases of neocortical function has to be reached. This is the purpose of our research.

Beyond the goal to understand the function of the neocortex we have started to direct our research toward possible future applications. We work toward the establishment of cortical sensory neuroprostheses, that in the future might help those patients, who lost a sense due to a disease of the central nervous system. A major problem is that percepts produced by electrical activation of cortical networks depend very much on the sensory and behavioral context. Our solution to this problem is to establish intelligent implants that measure neural activity to assess information about contexts (i. e. the associative state of the cortical tissue to be activated) and use this to increase precision with which sensory signals can be imprinted into central neuronal structures and reach perception.

Research Projects
Doctoral and Master Theses

Cellular mechanisms of cerebellar nuclei neurons function

Project leader: Dr. Christine Pedroarena

The basic cerebellar circuit is highly conserved along phylogeny, particularly amongst mammals. On the other hand the large increase in cerebellar size along phylogeny suggests that larger numbers of the same modules provide an increased cerebellar capacity to support the increased complexity of brain functions and expansion of other brain areas. Therefore, the investigations of the basic modular cerebellar circuits carried out in rodents provide useful insights about the human cerebellar function (or dysfunction). The most recognized function of the cerebellum is sensorimotor coordination and its adaptation to environmental changes. This role is illustrated by the severe incoordination of movements and impaired capacity to learn new motor tasks in most forms of cerebellar disease. More recently, a possible role of cerebellum in cognitive functions has been proposed, an idea supported by the involvement of cerebellum in cognitive deficits syndromes, such as autistic disorders.

Our research is focused on the neurons of the deep cerebellar nuclei (DCN). The axons of these cells provide the output pathways of cerebellum and thus are the signals of these cells that ultimately exert the cerebellar control on target structures. Deep cerebellar nuclei neurons are spared in many cerebellar diseases or their function is altered only secondarily to the alterations occurring at the cerebellar cortex. Hence, cerebellar nuclei are a natural place for compensatory mechanisms for diseases affecting the cerebellar cortex. We investigate the cellular mechanisms (synaptic and membrane properties) determining cerebellar nuclei neurons output and its plastic changes and how these might be affected by cerebellar disease, or can be modulated by external agents, with the goal to ultimately understand cerebellar function and provide rational basis for new therapies.

To this end we use in vitro electrophysiological patch recordings and microstimulation combined with optogenetics in brain slices taken from wild type or transgenic animals and immuno-histochemistry staining techniques.

Research Group
Dr. Alia Benali
Dr. Alia BenaliPostDoc
Systems Neurophysiology Lab
07071 29-89033 
Dr. Arindam Bhattacharjee
Dr. Arindam BhattacharjeePostDoc
Systems Neurophysiology Lab
07071 29-88900 
 Kalpana Gupta
Kalpana GuptaPhD Student
Systems Neurophysiology Lab
07071 29-89029 
 Bingshuo Li
Bingshuo LiPhD Student
Systems Neurophysiology Lab
07071 29-89029 
 Maysam Oladazimi
Maysam OladazimiPostDoc
Systems Neurophysiology Lab
07071 29-89029 
 Ursula Pascht
Ursula PaschtTechnical Assistant
Systems Neurophysiology Lab
07071 29-89025 
Dr. Christine Pedroarena
Dr. Christine PedroarenaPostDoc
Systems Neurophysiology Lab
07071 29-87602 
Prof. Dr. Cornelius Schwarz
Prof. Dr. Cornelius SchwarzResearch Group Leader
Systems Neurophysiology Lab
07071 29-80462 
 May Li Silva Prieto
May Li Silva PrietoPhD Student
Systems Neurophysiology Lab
07071 29-88900 


Hofmann JI, Schwarz C, Rudolph U, Antkowiak B (2019) Effects of diazepam on low-frequency and high-frequency electrocortical ?-power mediated by ?1- and ?2-GABAA receptors. International Journal of Molecular Science 20:3486



Chakrabarti S, Schwarz C (2018). Cortical modulation of sensory flow during active touch in the rat whisker system. Nature Communications 9:3907; DOI: 10.1038/s41467-018-06200-6

Gerdjikov TV, Bergner CG, Schwarz C (2018). Global tactile coding in rat barrel cortex in the absence of local cues. Cerebral Cortex 28:2015-2027; doi: 10.1093/cercor/bhx108.

Oladazimi M, Brendel W, Schwarz C (2018). Biomechanical texture coding in rat whiskers. Scientific Reports 8:11139; doi:10.1038/s41598-018-29225-9.

Stüttgen MC, Schwarz C (2018). Barrel Cortex: What is it good for? Neuroscience 368:8-16; doi:10.1016/j.neuroscience.2017.05.009

Waiblinger C, Whitmire CJ, Sederberg A, Stanley GB, Schwarz C (2018). Primary tactile thalamus spiking reflects cognitive signals. Journal of Neuroscience 38:4870-4885.



Stüttgen MC, Schwarz C (2017) Barrel Cortex: What Is It Good For? Neuroscience: doi: 10.1016/j.neuroscience.2017.05.009 [Epub ahead of print]

Gerdjikov TV, Bergner CG, Schwarz C (2017) Global Coding in Rat Barrel Cortex in the Absence of Local Cues. Cerebral Cortex: doi: 10.1093/cercor/bhx108 [Epub ahead of print]



Schwarz C (2016) The slip hypothesis: Tactile perception and its neuronal bases. Trends in Neurosciences 39(7): 449-462. doi: 10.1016/j.tins.2016.04.008.



Chakrabarti S, Schwarz C (2015) The rodent vibrissal system as a model to study motor cortex function. In: Sensorimotor Integration in the Whisker System. Krieger P, Groh A (eds), Springer, New York, pp 129-148

Chakrabarti S, Schwarz S (2015) Whisking control by motor cortex. Journal of Scholarpedia 10(3):7466

Joachimsthaler B, Brugger D, Skodras A, Schwarz C (2015) Spine loss in primary somatosensory cortex during trace eyeblink conditioning Journal of Neuroscience 35:3772-3781

Schwarz C (2015) Monosynaptic retrograde tracing starts to close the gaps in our understanding of complex premotor networks (Commentary on Sreenivasan et al.). European Journal of Neuroscience 41:352-353

Smith JB, Watson GD, Alloway KD, Schwarz C, Chakrabarti S (2015) Corticofugal projection patterns across the whisker representations to the sensory trigeminal nuclei. Frontiers in Neural Circuits 9:53. doi: 10.3389/fncir.2015.00053. eCollection 2015.

Waiblinger C, Brugger D, Schwarz C (2015) Vibrotactile discrimination in the rat whisker system is based on neuronal coding of instantaneous kinematic cues. Cerebral Cortex 25:1093-1106

Waiblinger C, Brugger D, Whitmire CJ, Stanley GB, Schwarz C (2015) Support for the slip hypothesis from whisker-related tactile perception of rats in a noisy environment. Front Integr Neurosci 2015 Oct 15;9:53. doi: 10.3389/fnint.2015.00053.



Chakrabarti, S., Schwarz, C. (2014) Studying motor cortex function using the rodent vibrissal system. e-Neuroforum 5:20-27. doi: 10.1007/s13295-014-0051-y

Georgieva, P., Brugger, D. and Schwarz, C. (2014) Are spatial frequency cues used for whisker-based active discrimination? Front.Behav.Neurosci. 8:379. doi: 10.3389/fnbeh.2014.00379



Feldmeyer, D., Brecht, M., Helmchen, F., Petersen, C.C.H., Poulet, J., Staiger, J., Luhmann, H., Schwarz C. (2013) Barrel cortex function. Progress in Neurobiology 103: 3–27

Gerdjikov T.V., Haiss F., Rodriguez-Sierra O., Schwarz C. (2013) Rhythmic whisking area (RW) in rat primary motor cortex: an internal monitor of movement-related signals? J Neurosci 33:14193–14204

Theis, L., Chagas, A.M. Arnstein, D., Schwarz, C., Bethge, M. (2013) Beyond GLMs: A generative mixture modeling approach to neural system identification. PLOS Comp. Biol., 9:e1003356. doi: 10.1371/journal.pcbi.1003356

Chagas, A.M.; Theis, L., Sengupta, B., Stüttgen, M.C., Bethge, M., Schwarz, C. (2013) Functional analysis of ultra high information rates conveyed by rat vibrissal primary afferents. Front. Neural Circuits 7:190. doi: 10.3389/fncir.2013.00190



Quadrato G, Benevento M, Alber S, Jacob C, Floriddia EM, Nguyen T, Elnaggar MY, Pedroarena CM, Molkentin JD and Di Giovanni S. (2012). Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus. Proc Natl Acad Sci USA 109:E1499-1508



Pedroarena CM (2011) BK and Kv3.1 Potassium Channels Control Different Aspects of Deep Cerebellar Nuclear Neurons Action Potentials and Spiking Activity. Cerebellum. 2011 Jul 13. [Epub ahead of print]. DOI:10.1007/s12311-011-0279-9

Braun, C., Eisele, E, Wühle, A., Stüttgen, M., Schwarz, C., Demarchi G. (2011) Mislocalization of near-threshold tactile stimuli in humans: a central or peripheral phenomenon. Eur. J. Neurosci., 33:499-508

Brugger, D., Butovas, S., Bogdan, M., Schwarz, C. (2011) Real-time adaptive microstimulation increases reliability of electrically evoked cortical potentials. IEEE Trans. Biomed. Eng., 58: 1483-1491

Stüttgen, M.C., Schwarz, C., Jäkel, F. (2011) Mapping spikes to sensations. Front.Neurosci. 5:125 



Belmeguenai A, Hosy E, Bengtsson F, Pedroarena C, Teuling CPE, He Q, Ohtsuki G, De Jeu MTG, Elgersma Y, De Zeeuw CI, Jörntel H, Hansel C (2010) Intrinsic plasticity complements LTP in parallel fiber input gain control in cerebellar Purkinje cells. J Neurosci 30(41):13630-13643

Schwarz, C. (2010) The fate of spontaneous synchronous rhythms on the cerebro-cerebellar loop. Cerebellum 9:77-87 

Stüttgen M.C. and Schwarz C. (2010) Integration of vibrotactile signals for whisker-related perception in rats is governed by short time constants: comparison of neurometric and psychometric detection performance. J. Neurosci. 30:2060-2069.

Haiss, F., Butovas, S., Schwarz, C. (2010) A miniaturized chronic microelectrode drive for awake behaving head restrained mice and rats. J. Neurosci. Meth., 187:67-72

Gerdjikov, T.V., Bergner, C.G., Stüttgen, M.C., Waiblinger, C., Schwarz, C. (2010) Discrimination of vibrotactile stimuli in the rat whisker system - behavior and neurometrics. Neuron, 65:530-540

Butovas, S., Rudolph, U., Jurd, R., Schwarz, C., Antkowiak, B. (2010) Activity patterns in the prefrontal cortex and hippocampus during and after awakening from etomidate anesthesia. Anesthesiology, 113:48-57

Schwarz, C., Hentschke, H., Butovas, S., Haiss, F., Stüttgen, M.C., Gerdjikov, T.V., Bergner, C.G. Waiblinger, C. (2010) The head-fixed behaving rat – procedures and pitfalls. Somatosensory & Motor Research, 27:131-48

Kreuzer, M., Hentschke, H., Antkowiak, B., Schwarz, C., Kochs, E.F., Schneider, G. (2010) Cross-Approximate Entropy of cortical local field potentials quantifies effects of anesthesia - a pilot study in rats. BMC Neuroscience, 11:122


Weitere Publikationen finden sie unter:

Ongoing dissertation work


André Maia Chagas (GSNBS)
Supervisor Prof. Dr. C. Schwarz

Julian Hofmann (GSNBS)
Supervisor Prof. Dr. C. Schwarz

Maysam Oladazimi (GSNBS)
Supervisor Prof. Dr. C. Schwarz

Bingshuo Li (GSNBS)
Supervisor Prof. Dr. C. Schwarz / Prof. Dr. U. Ziemann


Completed dissertations (since 2000)


Christian Waiblinger (2015)
The role of kinematic events in whisker-related tactile perception
Prof. Dr. C. Schwarz

Petya Georgieva (2014)
Active perception of virtual texture frequency in the whisker-related sensorimotor system of the rat
Prof. Dr. C. Schwarz

Bettina Joachimsthaler (2014)
Two photon imaging of structural plasticity underlying classical eyeblink conditioning in mouse barrel cortex
Prof. Dr. C. Schwarz

Caroline Bergner (2012)
Neuronal correlates of frequency discrimination in the tactile system
Prof. Dr. C. Schwarz

Isabella Schmeh (2012)
Gene expression of potential modulators of inhibitory neurotransmission in the Lurcher mutant mouse
Prof. Dr. C. Schwarz

Dominik Brugger (2009)
Adaptive microstimulation for stabilizing evoked cortical potentials
Prof. Dr. C. Schwarz

Florent Haiss (2007)
Contributions of motor areas to sensory processing during active and passive touch
Prof. Dr. C. Schwarz

Maik Stüttgen (2007)
Psychophysical channels and the physiology of perception in the rat whisker system
Betreuer Prof. Dr. C. Schwarz

Sergejus Butovas (2007)
Local synaptic effects of microstimulation in barrel cortex and pontine nuclei in the rat
Prof. Dr. C. Schwarz

Susanne Kamphausen (2006)
Functional architecture of the cerebellar nuclei: Investigations of membrane physiology, morphology, and glycinergic synaptic transmission of cerebellar nuclei neurons
Prof. Dr. C. Schwarz 

Anja Horowski (2002)
Organization of tectopontine axon terminals with respect to the projections from visual and somatosensory cortices and dendritic fields of pontine projection neurons: Compartmentalization of rat pontine nuclei
Prof. Dr. P. Thier, Prof. Dr. C. Schwarz

Uwe Czubayko (2000)
A characterization of neuronal types in rat cerebellar nuclei using electrophysiological and morphological properties
Prof. Dr. P. Thier, Prof. Dr. C. Schwarz

Research Group Leader
Head of the research groupSystems Neurophysiology Lab
Prof. Dr. Cornelius SchwarzPhone 07071

Center of Neurology
Hertie Institute for Clinical Brain Research

Otfried-Müller-Straße 25
72076 Tübingen

Phone: +49 (0)7071 29-80462
Fax: +49 (0)7071 29-25011