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Tabatabai Lab

Laboratory for Clinical and Experimental Neuro-Oncology

The projects of the Clinical and Experimental Neurooncology Laboratory focus on the biology of tumors of the nervous system, with special emphasis on molecular mechanisms of tumorigenesis, acquired therapy resistance, and treatment-induced vulnerability. Our projects are translationally oriented, i.e. the questions of our projects are based on unsolved clinical challenges. Our ambition is to achieve further development of therapeutic strategies in phase I/II trials. Our research projects thus span the entire translational chain of discovery, validation and application with constant forward and reverse translation.

 

Publications
Members
Partners and Collaborations

 

Full list of publications

Link Google Scholar

 

Selected Publications (last 3 years)

Omuro A, Brandes AA, Carpentier AF, Idbaih A, Reardon DA, Cloughesy T, Sumrall A, Baehring J, van den Bent M, Bähr O, Lombardi G, Mulholland P, Tabatabai G, Lassen U, Sepulveda JM, Khasraw M, Vauleon E, Muragaki Y, Di Giacomo AM, Butowski N, Roth P, Qian X, Fu AZ, Liu Y, Potter V, Chalamandaris AG, Tatsuoka K, Lim M, Weller M. Radiotherapy Combined With Nivolumab or Temozolomide for Newly Diagnosed Glioblastoma With Unmethylated MGMT Promoter: An International Randomized Phase 3 Trial. Neuro Oncol. 2022 Apr 14:noac099. doi: 10.1093/neuonc/noac099. Epub ahead of print.

Trautwein C, Zizmare L, Mäurer I, Bender B, Bayer B, Ernemann U, Tatagiba M, Grau SJ, Pichler BJ, Skardelly M, Tabatabai G. Tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment. JCI Insight. 2022 Feb 8;7(3):e153526. doi: 10.1172/jci.insight.

Walter B, Canjuga D, Yüz SG, Ghosh M, Bozko P, Przystal JM, Govindarajan P, Anderle N, Keller A-L, Tatagiba M, Schenke-Layland K, Rammensee H-G, Stevanovic S, Malek NP, Schmees C, Tabatabai G. Argyrin F Treatment-Induced Vulnerabilities Lead to a Novel Combination Therapy in Experimental Glioma. Adv. Therap. 2021, 2100078.

Nassiri F, Liu J, Patil V, Mamatjan Y, Wang JZ, Hugh-White R, Macklin AM, Khan S, Singh O, Karimi S, Corona RI, Liu LY, Chen CY, Chakravarthy A, Wei Q, Mehani B, Suppiah S, Gao A, Workewych AM, Tabatabai G, Boutros PC, Bader GD, de Carvalho DD, Kislinger T, Aldape K, Zadeh G. A clinically applicable integrative molecular classification of meningiomas. Nature. 2021 Sep;597(7874):119-125. doi: 10.1038/s41586-021-03850-3. Epub 2021 Aug 25.

Goldbrunner R, Stavrinou P, Jenkinson MD, Sahm F, Mawrin C, Weber DC, Preusser M, Minniti G, Lund-Johansen M, Lefranc F, Houdart E, Sallabanda K, Le Rhun E, Nieuwenhuizen D, Tabatabai G, Soffietti R, Weller M. EANO guideline on the diagnosis and management of meningiomas. Neuro Oncol. 2021 Nov 2;23(11):1821-1834. doi: 10.1093/neuonc/noab150.

Przystal JM, Becker H, Canjuga D, Tsiami F, Anderle N, Keller AL, Pohl A, Ries CH, Schmittnaegel M, Korinetska N, Koch M, Schittenhelm J, Tatagiba M, Schmees C, Beck SC, Tabatabai G. Targeting CSF1R Alone or in Combination with PD1 in Experimental Glioma. Cancers (Basel). 2021 May 15;13(10):2400. doi: 10.3390/cancers13102400. 

Platten M, Bunse L, Wick A, Bunse T, Le Cornet L, Harting I, Sahm F, Sanghvi K, Tan CL, Poschke I, Green E, Justesen S, Behrens GA, Breckwoldt MO, Freitag A, Rother LM, Schmitt A, Schnell O, Hense J, Misch M, Krex D, Stevanovic S, Tabatabai G, Steinbach JP, Bendszus M, von Deimling A, Schmitt M, Wick W. A vaccine targeting mutant IDH1 in newly diagnosed glioma. Nature. 2021 Apr;592(7854):463-468. doi: 10.1038/s41586-021-03363-z. Epub 2021 Mar 24.

Wick A, Bähr O, Schuler M, Rohrberg K, Chawla SP, Janku F, Schiff D, Heinemann V, Narita Y, Lenz HJ, Ikeda M, Ando Y, Wick W, Steinbach JP, Burger MC, Wenger K, Lassen U, Sankhala KK, Roggia C, Genvresse I, Munhoz C, Rentzsch C, Reschke S, Langer S, Wagner M, Kaulfuss S, Cai C, Lagkadinou E, Jeffers M, Peña C, Tabatabai G. Phase I Assessment of Safety and Therapeutic Activity of BAY1436032 in Patients with IDH1-Mutant Solid Tumors. Clin Cancer Res. 2021 May 15;27(10):2723-2733. doi: 10.1158/1078-0432.CCR-20-4256. Epub 2021 Feb 23.

Behling F, Fodi C, Gepfner-Tuma I, Kaltenbach K, Renovanz M, Paulsen F, Skardelly M, Honegger J, Tatagiba M; International Consortium on Meningiomas, Schittenhelm J, Tabatabai G. H3K27me3 loss indicates an increased risk of recurrence in the Tübingen meningioma cohort. Neuro Oncol. 2021 Aug 2;23(8):1273-1281. doi: 10.1093/neuonc/noaa303.

Herrlinger U, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Sabel M, Hau P, Kortmann RD, Krex D, Grauer O, Goldbrunner R, Schnell O, Bähr O, Uhl M, Seidel C, Tabatabai G, Kowalski T, Ringel F, Schmidt-Graf F, Suchorska B, Brehmer S, Weyerbrock A, Renovanz M, Bullinger L, Galldiks N, Vajkoczy P, Misch M, Vatter H, Stuplich M, Schäfer N, Kebir S, Weller J, Schaub C, Stummer W, Tonn JC, Simon M, Keil VC, Nelles M, Urbach H, Coenen M, Wick W, Weller M, Fimmers R, Schmid M, Hattingen E, Pietsch T, Coch C, Glas M; Neurooncology Working Group of the German Cancer Society. Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial. Lancet. 2019 Feb 16;393(10172):678-688. doi: 10.1016/S0140-6736(18)31791-4. Epub 2019 Feb 14.


 
Name
Research Group
Phone
Email
 Yannik Bader
Yannik BaderMedical Student
Clinical and Experimental Neuro-Oncology

+49 (0)7071
29-83266

 
 Sigrid Baltes
Sigrid BaltesNurse
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-83266

 
 Björn Bayer
Björn BayerMedical doctoral student
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-83266

 
Dr. Susanne Beck
Dr. Susanne BeckScientific Coordinator
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-80449

 
Dr. med Hannes Becker
Dr. med Hannes BeckerPhysician
Clinical and Experimental Neuro-Oncology


 
Dr. Felix Behling
Dr. Felix BehlingPhysician
Clinical and Experimental Neuro-Oncology


 
Dr. Paula Bombach
Dr. Paula BombachPhysician
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-82174

 
 Matthias Damm
Matthias DammMedical Student
Clinical and Experimental Neuro-Oncology

+49 (0)7071
29-83266

 
 Yeliz Donat
Yeliz DonatMedical Technician
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-83618

 
 Caroline Eiden
Caroline EidenTrainee
Clinical and Experimental Neuro-Oncology


 
 Aaron Falkner
Aaron FalknerMedical doctoral student
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-81987

 
 Lucia Grosse
Lucia GrossePhysican
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-82174

 
 Isabel Gugel
Isabel GugelPhysician
Clinical and Experimental Neuro-Oncology


 
 Sarah Hendel
Sarah HendelMedical Technician
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-81987

 
 Melina Hippler
Melina HipplerProject Manager
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-82050

 
 Mona Hirt
Mona HirtMedical doctoral student
Clinical and Experimental Neuro-Oncology


 
Dr. Svenja Hucker
Dr. Svenja HuckerPhysician
Clinical and Experimental Neuro-Oncology

+49 (0) 7071-
29-82174

 
 Lara Häußer
Lara HäußerPhD Student
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-81987

 
 Marion Jeric
Marion JericNurse
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-83266

 
 Anke King
Anke KingPhD Student
Clinical and Experimental Neuro-Oncology


 
 Nataliya Korinetska
Nataliya KorinetskaMedical Student
Clinical and Experimental Neuro-Oncology


 
 Lukas-Michael Kugler
Lukas-Michael Kugler
Clinical and Experimental Neuro-Oncology


 
 Laurence Kuhlburger
Laurence KuhlburgerPhD Student
Clinical and Experimental Neuro-Oncology


 
Dr. Sylvia Kurz
Dr. Sylvia KurzPhysician
Clinical and Experimental Neuro-Oncology

49 (0) 7071
29-87419

 
 Wilhelm Lang
Wilhelm LangQuality Management ZNO
Clinical and Experimental Neuro-Oncology


 
 Susanne Luginsland
Susanne LuginslandSecretary
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-83269

 
 Louise Maise
Louise MaiseMedical doctoral student
Clinical and Experimental Neuro-Oncology


 
Dr. Susane Noell
Dr. Susane NoellPhysican
Clinical and Experimental Neuro-Oncology


 
 Linda Paul
Linda PaulMaster Student
Clinical and Experimental Neuro-Oncology


 
 Peter Paßlack
Peter PaßlackMedical Student
Clinical and Experimental Neuro-Oncology


 
 Heike Pfrommer
Heike PfrommerMA Clinical and Experimental Neuro-Oncology
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-81987

 
Dr. David Rieger
Dr. David RiegerPhysican
Clinical and Experimental Neuro-Oncology


 
 Johannes Rieger
Johannes RiegerPhysician
Clinical and Experimental Neuro-Oncology


 
Prof. Dr. Constantin Roder
Prof. Dr. Constantin RoderSenior Physican Neurosurgery
Clinical and Experimental Neuro-Oncology


 
Dr. Marlene Röttgen
Dr. Marlene RöttgenScientific Coordinator
Clinical and Experimental Neuro-Oncology


 
 Leonard Schnabel
Leonard SchnabelMedical doctoral student
Clinical and Experimental Neuro-Oncology


 
 Ann-Kathrin Schuhmacher
Ann-Kathrin SchuhmacherMFA Medizinische Fachangestellte
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-83266

 
 Hanna Schuster
Hanna SchusterBachelor Student
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-81960

 
Prof. Dr. Dr. Ghazaleh Tabatabai
Prof. Dr. Dr. Ghazaleh TabatabaiHead of Department
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-85018

 
 Tanja Urz
Tanja UrzMedical Student
Clinical and Experimental Neuro-Oncology


 
 Ute Walter
Ute WalterStudy Coordinator
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-82001

 
 Bianca Walter
Bianca WalterPhD student
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-82043

 
 Kirsten Wyrwich
Kirsten WyrwichCase Manager
Clinical and Experimental Neuro-Oncology

+49 (0)7071-
29-82050

 

We collaborate closely with national and international partners and alliances, including:

  • Deutsches Gliomnetzwerk (German Glioma Network)
  • the German Cancer Consortium (Deutsches Konsortium für Translationale Krebsforschung, DKTK)
  • the European Organisation for Research and Treatment of Cancer (EORTC)
  • the European Association of Neuro-Oncology (EANO)
  • the International Consortium on Meningioma (ICOM)
Research Group leaderDirector of the department
Prof. Dr. Dr. Ghazaleh TabatabaiPhone 07071 29-85018ghazaleh.tabatabai@uni-tuebingen.deAddress

Center of Neurology
Hertie Institute for Clinical Brain Research
Department of Neurology & Interdisciplinary Neuro-Oncology

Otfried-Müller-Straße 27
72076 Tübingen

Phone: +49 (0)7071 29-85018
Fax: +49 (0)7071 29-5957

Office

Susanne Luginsland
Phone: +49 (0)7071 29-83269
Fax: +49 (0)7071 29-5957
tabatabai.officemed.uni-tuebingen.de