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Laboratory for Clinical and Experimental Neuro-Oncology

The Interdisciplinary Division of Neuro-Oncology at the Hertie-Institut for Clinical Brain Research is the result of the, in the context of the Excellent Initiative, newly created W3-Professorship in Neuro-Oncology at the Eberhard-Karls-University Tübingen. This Division has been established at the University Hospital Tübingen (UKT) and is affiliated to the Centre of Neurology (Department Prof. Ziemann) and the Department of Neurosurgery (Prof. Dr. M. Tatagiba) in cooperation with the Department of Radio-Oncology (Prof. Dr. D. Zips). Out-patient and in-patient treatment of neuro-oncologycal patients is organised on an interdisciplinary basis under the umbrella of the Centre for Neuro-Oncology at the Comprehensive Cancer Center Tübingen-Stuttgart

The projects of the lab are focusing on the biology of brain tumors, especially with targeted individualized therapies, molecular mechanisms in the development of resistance and cell based therapy approaches.

The research team is supported by the German Scholars Organisation and the Else Kröner-Fresenius Stiftung.

This page is currently under construction

Publications
Staff
Partners and Collaborations

Selected publications

 

Niessner H, Schmitz J, Tabatabai G, Schmid A, Calaminus C, Sinnberg T, Weide B, Eigentler TK, Garbe C, Schittek B, Quintanilla-Fend L, Bender B, Mai M, Praetorius C, Beissert S, Schackert G, Muders M, Meinhardt M, Baretton GB, Dummer R, Flaherty KT, Pichler BJ, Kulms D, Westphal D, Meier F. PI3K pathway inhibition achieves potent antitumor activity in melanoma brain metastases in vitro and in vivo. Clin Cancer Res. 2016. [Epub ahead of print]

 

Skardelly M, Brendle E, Noell S, Behling F, Wuttke TV, Schittenhelm J, Bisdas S, Meisner C, Rona S, Tatagiba MS, Tabatabai G. Predictors of preoperative and early postoperative seizures in patients with intra-axial primary and metastatic brain tumors: A retrospective observational single center study. Ann Neurol. 2015;78(6):917-28.

 

Weller M, Tabatabai G, Kästner B, Felsberg J, Steinbach JP, Wick A, Schnell O, Hau P, Herrlinger U, Sabel MC, Wirsching HG, Ketter R, Bähr O, Platten M, Tonn JC, Schlegel U, Marosi C, Goldbrunner R, Stupp R, Homicsko K, Pichler J, Nikkhah G, Meixensberger J, Vajkoczy P, Kollias S, Hüsing J, Reifenberger G, Wick W; DIRECTOR Study Group. MGMT Promoter Methylation Is a Strong Prognostic Biomarker for Benefit from Dose-Intensified Temozolomide Rechallenge in Progressive Glioblastoma: The DIRECTOR Trial. Clin Cancer Res. 2015 May 1;21(9):2057-64. doi: 10.1158/1078-0432.CCR-14-2737. Epub 2015 Feb 5.

 

Wirsching HG, Krishnan S, Florea AM, Frei K, Hasenbach K, Reifenberger G, Krayenbuehl N, Weller M, Tabatabai G. Thymosin β4 gene silencing decreases stemness and invasiveness in glioblastoma. Brain 2014;137:433-48 

 

Gulbins E, Palmada M, Reichl M, Lüth A, Böhmer C, Amato D, Müller CP, Tischbirek CH, Groemer TW, Tabatabai G, Becker KA, Tripal B, Staedtler S, Ackerman TF, van Brederode J, Alzheimer C, Weller M, Lang UE, Kleuser B, Grassme H, Kornhuber J. Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. Nat Med 2013;19:934-938 

 

Gramatzki D, Herrmann C, Happold C, Becker KA, Gulbins E, Weller M, Tabatabai G. Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway. PLoS One 2013; 7;8(5):e63527

 

Spescha RD, Shi Y, Wegener S, Keller S, Weber B, Wyss MM, Lauinger N, Tabatabai G, Paneni F, Consentino F, Hock C, Weller M, Nitsch RM, Lüscher TF, Camici GG. Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury. Eur Heart J. 2013; 34: 96-103 

 

Wick W, Platten M, Meisner C, Felsberg J, Tabatabai G, Simon M, Nikkhah G, Papsdorf K, Steinbach JP, Sabel M, Combs SE, Vesper J, Braun C, Meixensberger J, Ketter R, Mayer-Steinacker R, Reifenberger G, Weller M. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomized, phase 3 trial. Lancet Oncol 2012; 13:707-715 

 

Hasenbach K, Wiehr S, Herrmann C, Mannheim J, Cay F, von Kürthy G, Bolmont T, Grathwohl SA, Weller M, Lengerke C, Pichler B, Tabatabai G. Monitoring the glioma tropism of bone marrow-derived progenitor cells by two-photon laser scanning microscopy and positron emission tomography. Neuro Oncol 2012; 12:302-307 

 

Schraivogel D, Weinmann L, Beier D, Tabatabai G, Eichner A, Zhu JY, Anton M, Sixt M, Weller M, Beier CP, Meister G. CAMTA is a novel tumor suppressor regulated by miR-9/9* in glioblastoma cells. EMBO J 2011; 30, 4309-4322


 
Name
Research Group
Phone
Email
 Yannik Bader
Yannik BaderMedical doctoral student
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Sigrid Baltes
Sigrid BaltesNurse
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-83266 
 Björn Bayer
Björn BayerMedical doctoral student
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-83266 
Dr. Susanne Beck
Dr. Susanne BeckScientific Coordinator
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-80449 
 Hannes Becker
Hannes BeckerMedical Student
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Dr. Felix Behling
Dr. Felix BehlingPhysician
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Dr. Paula Bombach
Dr. Paula BombachPhysician
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-82174 
 Matthias Damm
Matthias DammMedical doctoral student
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Yeliz Donat
Yeliz DonatMedical Technician
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-83618 
 Juliane Ebert
Juliane EbertMedical doctoral student
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Hulda Ewald
Hulda EwaldMedical doctoral student
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Ines Fachner
Ines FachnerMedical doctoral student
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Aaron Falkner
Aaron FalknerMedical doctoral student
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-81987 
 Lucia Grosse
Lucia GrossePhysican
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-82174 
 Isabel Gugel
Isabel GugelPhysician
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Sarah Hendel
Sarah HendelMedical Technician
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-81987 
 Melina Hippler
Melina HipplerProject Manager
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-82050 
 Mona Hirt
Mona HirtMedical doctoral student
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Lara Häußer
Lara HäußerPhD Student
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-81987 
 Marion Jeric
Marion JericNurse
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-83266 
 Patricia Kempter
Patricia KempterMedical doctoral student
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Nataliya Korinetska
Nataliya KorinetskaMedical Student
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Lukas-Michael Kugler
Lukas-Michael Kugler
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Wilhelm Lang
Wilhelm LangQuality Management ZNO
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Daniel Linden
Daniel LindenMedical doctoral student
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Susanne Luginsland
Susanne LuginslandSecretary
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29 - 83269 
 Katja Macoustra
Katja MacoustraMedical doctoral student
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Jens Maile
Jens MaileBachelor Student
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Dr. Susane Noell
Dr. Susane NoellPhysican
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Heike Pfrommer
Heike PfrommerMedical Technician
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-81987 
 Dr. David Rieger
Dr. David RiegerPhysican
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Dr. Johannes Rieger
Dr. Johannes RiegerBoard-certified Neurologist
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Prof. Dr. Constantin Roder
Prof. Dr. Constantin RoderSenior Physican Neurosurgery, Coordinator ZNO
Laboratory for Clinical and Experimental Neuro-Oncology
 
 Leonard Schnabel
Leonard SchnabelMedical doctoral student
Laboratory for Clinical and Experimental Neuro-Oncology
 
Dr. Edith Schneider
Dr. Edith Schneider
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29 - 81960 
 Foteini Tsiami
Foteini TsiamiPhD Student
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-82043 
 Ute Walter
Ute WalterStudy Coordinator
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-82001 
 Bianca Walter
Bianca WalterPhD student
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-82043 
 Kirsten Wyrwich
Kirsten WyrwichCase Manager
Laboratory for Clinical and Experimental Neuro-Oncology
07071 29-82050 

We collaborate closely with national and international partners and alliances, including:

  • Deutsches Gliomnetzwerk (German Glioma Network)
  • the German Cancer Consortium (Deutsches Konsortium für Translationale Krebsforschung, DKTK)
  • the European Organisation for Research and Treatment of Cancer (EORTC)
  • the European Association of Neuro-Oncology (EANO)
  • the International Consortium on Meningioma (ICOM)
Research group leader
Research group leader
Prof. Dr. Dr. Ghazaleh Tabatabaighazaleh.tabatabai@uni-tuebingen.deAddress

Center of Neurology
Hertie Institute for Clinical Brain Research
Department Neurology and Stroke

Otfried-Müller-Straße 27
72076 Tübingen

Phone: +49 (0)7071 29-85018
Fax: +49 (0)7071 29-5957