Paroxysmal neurological disorders include a broad spectrum of clinical entities such as migraine, episodic ataxia or myotonia. The research group is focussed on the clinical genetics of epilepsies and paroxysmal dyskinesias, paroxysmal neurological disorders with overlapping clinical and pathophysiological features. More Info
- Clinical and genetic analsysis of patients with epileptic encephalopathies and associated diseases
- Pathophysiology-triggert precision medicine
- Breathing disturbances in epilepsy patients
- Development of a seizure detection system
Seizure detection system: A wearable device undependently from EEG analysis will be developed (funding: Bundesministerin für Wirtschaft und Energie und Karlsruher Institut für Technologie)
Vibes: A noninterventional study of Vimpat (Lacosamide) added to one baseline antiepileptic drug therapy in patients with brain tumor-related epilepsy (funding: UCB)
A multicenter, single-Arm, open-Label, post-marketing safety study to evaluate the risk of seizure among subjects with metastatic castration-resistant prostate cancer treated with Enzalutamide who are at potential increased risk of seizure (funding: Astellas Pharma)
EURAP A European registry to detect malformations and neuropsychological deficits on antiepileptic drugs during pregnancy
Valor: a double-blind,randomized,placebo-controlled parallel group,multicenter study to evaluate the efficacy and safety of Lacosamide as adjunctive therapy for uncontrolled primary generalized tonic-clonic seizures in subjects with idiopathic generalized epilepsy (funding UCB)
A Phase 3, randomized, double-blind, placebo-controlled, crossover study to assess the efficacy and safety of UX007 in the treatment of movement disorders associated with Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS) (funding Ultragenyx)
Outpatient clinic for epilepsy patients
In this outpatient clinic patients with epilepsy and differential diagnosis (like syncopies, psychogenic non-epileptic seizures, narcolepsy, dyskinesia) are advised concerning medication, social aspects and surgery.
For more details please check the homepage of the Dept. of Neurology of the University of Tübigen.