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Weber Lab

Clinical Genetics of Paroxysmal Neurological Diseases


Paroxysmal neurological disorders include a broad spectrum of clinical entities such as migraine, episodic ataxia or myotonia. The research group is focussed on the clinical genetics of epilepsies and paroxysmal dyskinesias, paroxysmal neurological disorders with overlapping clinical and pathophysiological features. More Info

Research projects
Clinical studies
Working Group members
Outpatient Clinic
  • Clinical and genetic analsysis of patients with epileptic encephalopathies and associated diseases
  • Pathophysiology-triggert precision medicine
  • Breathing disturbances in epilepsy patients
  • Development of a seizure detection system


Seizure detection system: A wearable device undependently from EEG analysis will be developed (funding: Bundesministerin für Wirtschaft und Energie und Karlsruher Institut für Technologie)


Vibes: A noninterventional study of Vimpat (Lacosamide) added to one baseline antiepileptic drug therapy in patients with brain tumor-related epilepsy (funding: UCB)


A multicenter, single-Arm, open-Label, post-marketing safety study to evaluate the risk of seizure among subjects with metastatic castration-resistant prostate cancer treated with Enzalutamide who are at potential increased risk of seizure (funding: Astellas Pharma)


 A European registry to detect malformations and neuropsychological deficits on antiepileptic drugs during pregnancy


Valor: a double-blind,randomized,placebo-controlled parallel group,multicenter study to evaluate the efficacy and safety of  Lacosamide as adjunctive therapy for uncontrolled primary generalized tonic-clonic seizures in subjects with idiopathic generalized epilepsy (funding UCB)


A Phase 3, randomized, double-blind, placebo-controlled, crossover study to assess the efficacy and safety of UX007 in the treatment of movement disorders associated with Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS) (funding Ultragenyx)

Research Group
 Ana Fulgencio Maisch
Ana Fulgencio MaischTechnical Assistant
Clinical Genetics of Paroxysmal

+49 (0) 7071

 Josua Kegele
Josua KegelePhysician
Clinical Genetics of Paroxysmal

+49 (0) 7071

Prof. Dr. Yvonne Weber
Prof. Dr. Yvonne WeberResearch Group Leader
Clinical Genetics of Paroxysmal


Outpatient clinic for epilepsy patients


In this outpatient clinic patients with epilepsy and differential diagnosis (like syncopies, psychogenic non-epileptic seizures, narcolepsy, dyskinesia) are advised concerning medication, social aspects and surgery.

For more details please check the homepage of the Dept. of Neurology of the University of Tübigen.



Research Group leader
Prof. Dr. Yvonne

Center of Neurology
Hertie Institute for Clinical Brain Research
Department Neurology and Epileptology

Hoppe-Seyler-Straße 3
72072 Tübingen

Phone:  +49 (0)7071 29-80443 or
Phone:  +49 (0)7071 29-82048
Fax:  +49 (0)7071 29-4488