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FG Siegel

Neuronale Dynamik und Magnetenzephalographie

Das zentrale Ziel unseres Labors ist es, zu erforschen, wie dynamische Interaktionen weitverteilter Nervenzellpopulationen Kognition und Verhalten hervorbringen. Wie gehen aus den dynamischen neuronalen Interaktionen des Gehirns komplexe Prozesse wie Wahrnehmung, das Treffen von Entscheidungen oder motorisches Verhalten hervor? Welche neuronalen Mechanismen koordinieren diese Interaktionen, wie werden sie abhängig vom Verhaltenskontext reguliert und wie sind diese Interaktionen bei neuropsychiatrischen Erkrankungen gestört?

Um diese Fragen zu beantworten, verwenden wir einen interdisziplinären Mehrskalen-Ansatz und stellen Verbindungen zwischen Populationsmaßen neuronaler Aktivität und Mechanismen auf der zellulären und Schaltreisebene her. Hierfür kombinieren wir Magnet- und Elektroenzephalographie (MEG/EEG) am Menschen, elektrophysiologische Untersuchungen am Tiermodell, Psychophysik und hochentwickelte analytische Verfahren.

Forschungsprojekte
Mitarbeitende
Partner & Kooperationen
Publikationen

 

In English only

 

Spectral Fingerprints of Normal and Diseased Brain Function

One focus of the lab are oscillatory dynamics of neuronal activity. Brain activity exhibits oscillations, i.e. periodicity, at various different frequencies and spatial scales. These oscillations may not only serve as highly informative markers, or ‘spectral fingerprints’ of the circuit interactions involved in different cognitive functions but may also dynamically mediate these interactions.

In one line of research, we investigate these spectral fingerprints with MEG in the resting human brain. We investigate how networks of brain regions spontaneously coordinate their oscillations at different frequencies. Together with our clinical collaborators, we investigate these rhythmic networks as novel biomarkers of different neurological pathologies. Furthermore, we characterize the temporal microstructure of different brain rhythms and how they are linked to neuronal spiking at the cellular level.

 

Neuronal Dynamics During Cognition and Behavior

In another line of research, we investigate neural dynamics underlying specific cognitive functions. We characterize the flow of information and neuronal interactions across distributed cortical and sub-cortical networks during complex behavioral tasks, involving e.g. visual and auditory decision-making, attention, working memory, and proprioception. We investigate how sensory, cognitive, and motor neuronal information flows across the brain and how such information relates to neuronal oscillations, dynamics and interactions. Together with our clinical collaborators, we investigate alterations of neuronal dynamics during pathological conditions, such as e.g. dyslexia in children and spatial hearing in cochlear implant users.

 

Magnetoencephalography – Imaging Human Brain Dynamics

Magnetoencephalography (MEG) allows for non-invasively and directly measuring human brain activity with unparalleled temporal resolution and signal quality. Our lab operates the Tübingen MEG Center, which provides state-of-the-art MEG techniques and services to the Tübingen neuroscience community and beyond. The MEG Center hosts a 275-channels whole-head MEG system, synchronized high-density EEG, transcranial electrical stimulation, precise visual, auditory and somatosensory stimulation, various response systems and high-speed binocular eye-tracking. The MEG Center is involved in a broad spectrum of collaborative research projects with partners at the Center for Neurology, the Centre for Integrative Neuroscience, the Institute of Medical Psychology, the Department of Otolaryngology, the Centre for Ophthalmology, the Department of Psychiatry and Psychotherapy and the Department of Psychosomatic Medicine.


 
Name
Arbeitsgruppe
Telefon
E-Mail
 Joachim Bellet
Joachim BelletPostdoc
Neural Dynamics

+49-7071-
29-81199

 
 Fridos Bouraima
Fridos BouraimaMaster Student
Neural Dynamics

+49(0)-7071-
29-81196

 
 Christoph Braun
Christoph BraunPostdoc
Neural Dynamics

+49-7071-
29-87705

 
 Tim Brümmer
Tim BrümmerMedical Student
Neural Dynamics

+49(0)-7071-
29-81198

 
 Filippo Calarco
Filippo CalarcoMedical Student
Neural Dynamics

+49-7071-
29-81198

 
 Veronica Cueva-Villanueva
Veronica Cueva-VillanuevaTechnical Assistant
Neural Dynamics

+49(0)-7071-
29-81194

 
 Jürgen Dax
Jürgen DaxTechnical Assistant
Neural Dynamics

+49(0)-7071-
29-87706

 
 Janet Giehl
Janet GiehlPhD Student
Neural Dynamics

+49(0)-7071-
29-89108

 
 Antonino Greco
Antonino GrecoPostdoc
Neural Dynamics

+49(0)-7071-
29-87691

 
 Paul Hege
Paul HegePhD Student
Neural Dynamics

+49(0)-7071-
29-81198

 
 Chen Hui
Chen HuiPhD Student
Neural Dynamics

+49-7071-
29-81198

 
 Andrea Ibarra-Chaoul
Andrea Ibarra-ChaoulPhD Student
Neural Dynamics

+49(0)-7071-
29-85298

 
 Nadja Knoke
Nadja KnokeBachelor Student
Neural Dynamics

+49(0)-7071-
29-81196

 
 Timm Larbig
Timm Larbig
Neural Dynamics

+49(0)-7071-
29-87706

 
 Jungmin Lee
Jungmin LeePhD Student
Neural Dynamics

+49(0)-7071-
29-81200

 
 Siyu Li
Siyu LiPhD Student
Neural Dynamics

+49(0)-7071-
29-81198

 
 Qinglin Li
Qinglin LiPostdoc
Neural Dynamics

+49(0)-7071-
29-89108

 
Dr. Yiwen Li Hegner
Dr. Yiwen Li HegnerPostdoc
Neural Dynamics


 
 Hongyu Lu
Hongyu LuPhD Student
Neural Dynamics

+49(0)-7071-
29-81195

 
 Tobias Ludwig
Tobias LudwigPhD Student
Neural Dynamics

+49(0)-7071-
29-85298

 
Dr. Justus Marquetand
Dr. Justus MarquetandPhysician
Neural Dynamics


 
 Chrystina Montouri
Chrystina MontouriMedical Student
Neural Dynamics

+49(0)-7071-
29-81196

 
 Nima Noury
Nima NouryPostdoc
Neural Dynamics

+49(0)-7071-
29-81198

 
 Katrina Quinn
Katrina QuinnPhD Student
Neural Dynamics

+49(0)-7071-
29-81199

 
 Clara Rastelli
Clara RastelliPhD Student
Neural Dynamics

+49(0)-7071-
29-87691

 
 Giulia Righetti
Giulia RighettiPhD Student
Neural Dynamics

+49(0)-7071-
29-81194

 
 Valentina Romagnano
Valentina RomagnanoPhD Student
Neural Dynamics

+49(0)-7071-
29-81194

 
 Florian Sandhäger
Florian SandhägerPhD Student
Neural Dynamics

+49(0)-7071-
29-81199

 
 Jan Schlüsener
Jan SchlüsenerPhD Student
Neural Dynamics

+49(0)-7071-
29-81199

 
 Ma Shanqian
Ma ShanqianTechnical Assistant
Neural Dynamics


 
Prof. Dr Markus Siegel
Prof. Dr Markus SiegelResearch Group Leader
Neural Dynamics

+49 (0)7071
29-85297

 
 Davide Sometti
Davide SomettiPhD Student
Neural Dynamics

+49(0)-7071-
29-81195

 
 Aleksejs Timcenko
Aleksejs TimcenkoMaster Student
Neural Dynamics

+49(0)-7071-
29-89108

 
 Vera Voigtländer
Vera VoigtländerPhD Student
Neural Dynamics

+49(0)-7071-
29-81198

 
 Gabi Walker-Dietrich
Gabi Walker-DietrichTechnical Assistant
Neural Dynamics

+49(0)-7071-
29-87706

 
 Haodi Yang
Haodi YangPhD Student
Neural Dynamics

+49(0)-7071-
29-81198

 
 Ema Zezelic
Ema ZezelicMaster Student
Neural Dynamics

+49(0)-7071-
29-81198

 
 Constantin von Nicolai
Constantin von NicolaiPostdoc
Neural Dynamics

+49(0)-7071-
29-81200

 

Ausgewählte Publikationen

· Pellegrini F, Hawellek DJ, Pape AA, Hipp JF, Siegel M (2020) Motion Coherence and Luminance Contrast Interact in Driving Visual Gamma-Band Activity. Cerebral Cortex ePub

· Siems M, Siegel M (2020) Dissociated neuronal phase- and amplitude-coupling patterns in the human brain. Neuroimage 209:116538 

· Trainito C, von Nicolai C, Miller EK, Siegel M (2019) Extracellular spike waveform dissociates four functionally distinct cell classes in primate cortex. Current Biology 29 

· Fioravanti C, Kajal SD, Carboni M, Mazzetti C, Ziemann U, Braun C (2019) Inhibition in the somatosensory system: An integrative neuropharmacological and neuroimaging approach. Neuroimage; 202:116139.

· Sandhaeger F, von Nicolai C, Miller EK, Siegel M (2019) Monkey EEG links neuronal color and motion information across species and scales. eLife 8:e45645 

· Wang H, Braun C, Murphy EF, Enck P (2019) Bifidobacterium longum 1714™ Strain Modulates Brain Activity of Healthy Volunteers During Social Stress. Am J Gastroenterol; 114(7):1152-1162

· Broser PJ, Knappe S, Kajal DS, Noury N, Alem O, Shah V, Braun C (2018) Optically Pumped Magnetometers for Magneto-Myography to Study the Innervation of the Hand. IEEE Trans Neural Syst Rehabil Eng; 26(11): 2226-2230.

· Pape AA and Siegel M (2016) Motor cortex activity predicts response alternation during sensorimotor decisions. Nature Communications 7:13098 

· Siegel M, Buschman TJ and Miller EK (2015) Cortical Information Flow During Flexible Sensorimotor Decisions. Science 348(6241): 1352-55 

· Hipp JF and Siegel M (2015) BOLD fMRI Correlation Reflects Frequency-Specific Neuronal Correlation. Current Biology 25, 1368-1374 

· Weisz N, Wühle A, Monittola G, Demarchi G, Frey J, Popov T, Braun C. (2014). Prestimulus oscillatory power and connectivity patterns predispose conscious somatosensory perception. PNAS.;111(4): E417-425.

· Hipp JF, Hawellek DJ, Corbetta M, Siegel M and Engel AK (2012) Large-scale cortical correlation structure of spontaneous oscillatory activity. Nature Neuroscience 15:884-890 

· Siegel M, Donner TH and Engel AK (2012) Spectral fingerprints of large-scale neuronal interactions. Nature Reviews Neuroscience 13:121-134 

· Hipp JF, Engel AK and Siegel M (2011) Oscillatory Synchronization in Large-Scale Cortical Networks Predicts Perception. Neuron 69: 387-396 

· Siegel M, Warden MR and Miller EK (2009) Phase-Dependent Neuronal Coding of Objects in Short-Term Memory. PNAS 106(50): 21341–21346 

· Siegel M, Donner TH, Oostenveld R, Fries P and Engel AK (2008) Neuronal Synchronization along the Dorsal Visual Pathway Reflects the Focus of Spatial Attention. Neuron 60: 709-719

· Miltner WHR, Braun C, Arnold M, Witte H, Taub E (1999) Coherence of gamma-band EEG activity as a basis for associative learning. Nature, 397: 434-436.

Leitung ForschungsgruppeDirektor der Abteilung
Prof. Dr. Markus SiegelTelefon 07071 29-81200 / 85297markus.siegel@uni-tuebingen.deAnschrift

Zentrum für Neurologie
Hertie-Institut für klinische Hirnforschung
Abteilung Neuronale Dynamik und Magnetenzephalographie

Otfried-Müller-Straße 25
72076 Tübingen

Tel.: +49 (0)7071 29-81200 / 85297
Fax: +49 (0)7071 29-25002