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Laying the foundations for tomorrow's medicine

News

  • Open House Presentation at the HIH

    The brain is one of the last great mysteries of mankind. It helps us to perceive, think and act. What happens when it becomes affected by illnesses? How can we recognize, treat or even avoid disorders? These questions will be answered at the Open House Presentation of the Hertie Institute on Sunday, 13 October 2019, 3 to 6 PM. The motto is "The fascination of the brain - What we think makes us think". A broad program of experiments, presentations and lectures will give you exciting insights into the world of clinical brain research.

    We are looking forward to your visit!

    To the flyer

  • Call for Application: HIH Junior Research Group

    The HIH is currently seeking young and highly motivated scientists from all over the world who wish to set up their own independent junior research group. Interested applicants should want to pursue a career in any field of basic, translational or clinical neurosciences that complements and enriches the existing strengths at the HIH. The research group will have full access to cutting-edge scientific infrastructure, state-of-the-art equipment, the University Hospital of Neurology, and the rich collaborative opportunities.

    For more information, please see the job vacancy.

    You can find more open positions in our career section.

  • AI and Medicine

    Artificial intelligence has become an integral part of medical research - but what role does it really play in the race for the future? Professor Dr. Hans-Peter Thier, head of the Department of Cognitive Neurology at the HIH, met with the Hertie Foundation and Professor Dr. Philipp Berens, expert in data science in visual research at the Research Institute of Ophthalmology at the University of Tübingen. In an interview, the neuroscientist and bioinformatician talk about the opportunities and risks involved in the interaction between humans and machines.

    To the interview

  • HIH researchers identify four different neuronal cell types based on their activity pattern in the cortex

    Nerve cells communicate with each other by means of electrical signals. Notably, these electrical signals, so called action potentials, seem to differ characteristically between distinct types of neurons. Researchers led by Professor Dr. Markus Siegel used fine microelectrodes to measure neuronal activity in different areas of the cerebral cortex. They found out that action potentials showed very distinct shapes. Based on these shapes, the scientists succeeded in classifying neurons into four different groups. These groups of neurons differed in their activity patterns and in the information that they encoded. “This opens a new window to study cell type-specific mechanisms and functions of neuronal circuits in the cerebral cortex,” explains Siegel. The study has been published in the current issue of the journal Current Biology.

    Copyright: AdobeStock

  • More than a twich: microsaccades are voluntary eye movements

    Microsaccades are not involuntary, spontaneous eye movements, as it has been assumed. Instead, we can perform them at will. A team led by Professor Dr. Ziad Hafed provide evidence against the prevailing view in the current issue of Nature Communications. They demonstrate that the tiny, rapid eye movements show different characteristics of voluntary behavior. “The results completely change the role we attribute to these eye movements in vision, cognition, and memory. Now, one has to consider microsaccades as genuine, purposeful movements,” Hafed says. As a consequence, neuroscientists need to pay more attention to them in the future: microsaccades occur in every experiment in which eye movements are fixated.

Departments

  • Neurology and Stroke

    The Department of Neurology and Stroke has the main focuses in neurovascular medicine (vessel diseases of the brain, cerebral stroke), neuro-oncology (brain tumors, brain metastases), neuro-immunology (e.g., multiple sclerosis) and neuro-intensive medicine. ...more information

  • Neurodegenerative Diseases

    The Department of Neurodegenerative Diseases treats in-patients on a ward of about 20 beds and in several out-patient clinics. The clinical focus lies on neurodegenerative diseases such as Parkinson’s disease, the ataxias, spastic paraplegias, and dementias. ...more information

  • Neurology and Epileptology

    The Department of Neurology and Epileptology has a focus on epilepsy and other paroxysmal neurological disorders. In these diseases, the excitability of nerve cells temporarily changes either due to genetic or acquired defects. ...more information

  • Cognitive Neurology

    The Department of Cognitive Neurology provides consultant and outpatient neuropsychological care. Another clinical focus is the treatment of chronic dizziness in the interdisciplinary dizziness center “Südwestdeutsches Schwindelzentrum” operated in conjunction ..more information

  • Cellular Neurology

    The focus of the Department of Cellular Neurology lies on cellular and molecular mechanisms in the aging brain and age-related neurodegenerative diseases. Special emphasis is placed on Alzheimer's disease, the most common and severe form of senile dementia. ...more information

  • Independent Research Groups

    The independent research group at the HIH focuses on the physiology of learning and memory ...more information

Research groups

  • Neurology and Stroke

    Brain Networks and Plasticity

    The human brain possesses the remarkable capacity of reorganization, which is the basis for adapting to constantly changing environmental conditions. This plasticity is of paramount importance ...more information

  • Cognitive Neurology

    Neuropsychology of Action

    The Research Group "Neuropsychology of Action" is dedicated to investigations of human action control. We study clinical impairments of action control and their neural substrates in patients with brain damage ...more information

  • Cellular Neurology

    Experimental Neuroimmunology

    An immune response is part of most neurological diseases, and the development of late-onset Alzheimer's Disease (AD) has been linked to immune related genes and most recently also to epigenetic modifications. ...more information

  • Neurodegenerative Diseases

    Genetics of Parkinson's disease

    Parkinson's syndrome (PS) is the second most common neurodegenerative disease after Alzheimer's dementia. The vast majority of patients are ill with no apparent cause. ...more information

  • Cellular Neurology

    Section for Dementia Research

    The Section for Dementia Research of the Department of Cellular Neurology and the University Clinic for Psychiatry and Psychotherapy is headed by Prof. Dr. Christoph Laske. The section consists ...more information

  • Neurology and Epileptology

    Clinical Genetics of Paroxysmal Neurological Diseases

    Paroxysmal neurological disorders include a broad spectrum of clinical entities such as migraine, episodic ataxia or myotonia. The research group is focussed on the clinical genetics ...more information

  • Cognitive Neurology

    Neuro-Vestibular Diagnostics

    The complaint of dizziness is highly prevalent but remains often an enigma to the physician in daily practice. Serious diseases potentially accompanied by dizziness like stroke, multiple sclerosis ...more information

  • Cognitive Neurology

    Oculomotor Laboratory

    Playing video-games is a widely distributed leisure activity in our society. In order to estimate the consequences of video-game play, we study the details of eye movements and pupil light responses ... more information

  • Cellular Neurology

    Experimental Neuropathology

    Cerebral proteopathy is a unifying term for cerebral neurodegenerative diseases in which aggregated proteins are abnormally deposited in the brain. The hallmark proteopathy is Alzheimer's disease (AD) ...more information

  • Neurodegenerative Diseases

    Functional Neurogenomics

    Neurodegenerative disorders are associated in a proportion of cases with genetic risk and gene mutations. However, the vast majority of cases of Parkinson’s disease are sporadic and the disease is altogether heterogeneous in symptoms and pathology. ...more information

  • Independent Research Group

    Molecular Brain Development

    The mammalian neocortex is a highly complex and spatially heterogeneous structure, which has expanded significantly in mammalian evolution. Neocortical network function is at the heart of cognitive function ...more info

  • Neurology and Stroke

    Neurological B cell Immunology

    The research group “Neurological B cell Immunology” is focused on the role of B cells in neuro-inflammatory diseases including multiple sclerosis (MS) and ...more information

Research groups

  • Neurodegenerative Diseases

    Clinical Parkinson's Disease Research

    Parkinson's disease (PD) is the second most frequent neurodegenerative disorder after Alzheimer’s disease and affects about 1 to 2 % of individuals over the age of 65. The number is steadily increasing due to demographic changes in Western countries. ...more information

  • Cellular Neurology

    Molecular Imaging Unit

    The Molecular Imaging Unit focuses on the visualization of Alzheimer’s disease (AD) and Parkinson's disease (PD) related changes in model systems using in vivo multiphoton microscopy ...more information

  • Neurology and Stroke

    Molecular Neurooncology

    Three to five of 100.000 people are annually diagnosed with a glioblastoma (GBM), the most malignant brain tumor in adults. Despite aggressive multimodal treatment including surgical resection and ...more information

  •  Unit

    Cellular Neurology

    Molecular Biomarkers Unit

    Processes related to Alzheimer ́s disease (AD) and other age-related neurodegenerative diseases start many years before the onset of the first clinical symptoms. At the moment of the first clinical complaints, the disease has already caused ...more information

  • Neurology and Stroke

    Interdisciplinary Section of Neuro-Oncology

    The projects of the lab are focusing on the biology of brain tumors, especially with targeted individualized therapies, molecular mechanisms in the development of resistance and cell based therapy approaches ...more information

  • Neurology and Epileptology

    Translational Imaging

    The focus of our research group is the structural and functional imaging of neurological diseases with a particular focus on epileptology. We use multi-modal imaging techniques to improve the understanding of disease development ...more information

  • Neurodegenerative Diseases

    Dystonia

    Dystonia is the third most common movement disorder, and mutations in a growing number of genes have been identified as causes for hereditary forms in many cases. The aim of the group, which brings together clinical experience ...more information

  • Neurology and Stroke

    Neurophonetics and Translational Neurorehabilitation

    The work group Neurophonetics and Translational Neurorehabilitation is based on a cooperation between the University of Tübingen and a neurological rehabilitation clinic (Fachkliniken Hohenurach). ...more information

  • Neurology and Stroke

    Stroke and Neuroprotection

    The research focus of our Stroke and Neuroprotection Laboratory is to find new and to optimize existing neuroprotective strategies ...more information

  • Neurology and Epileptology

    Experimental Epileptology

    Our research group is interested to unravel the mechanisms of well defined, mainly genetic, neurological, paroxysmal diseases, to understand correlations with clinical symptoms and to find new treatment options. ...more information

  • Cognitive Neurology

    Active Perception Lab

    Humans are tremendously reliant on the sense of vision to interact with their environment. Such interaction often involves the generation of motor outputs ...more information

  • Neurodegenerative Diseases

    Mitochondrial Biology of Parkinson’s Disease

    Neurodegenerative disorders are associated in a proportion of cases with genetic risk and gene mutations. However, the vast majority …more info

Research groups

  • Neurology and Epileptology

    Migraines and Primary Headache Disorders

    Our group aims at unraveling the molecular pathophysiology of migraine and other primary headache disorders. ...more information

  • Neurodegenerative Diseases

    Section for Clinical Neurogenetics

    Neurogenetic diseases like cerebellar ataxia, hereditary spastic paraplegia and leukodystrophy are rare disorders. ...more information

  • Neurodegenerative Diseases

    Systems Neurodegeneration

    Our research focuses on the investigation of the genetic basis, systems neuroscience and paradigmatic therapy approaches in ...more information

  • Cognitive Neurology

    Sensorimotor Lab

    The lab addresses a variety of topics that, at first glance, may look disparate. Yet, there is a common denominator ...more information

  • Neurodegenerative Diseases

    Genomic of Rare Movement Disorders

    Our group specializes in rare diseases. A disease is called rare, when it affects no more than 5 of 100,000 people. However, in the grand-scheme of things, rare diseases are not quite so rare ...more information

  • Cognitive Neurology

    Section for Computational Sensomotorics

    The Section for Computational Sensomotorics investigates theoretical principles in the perception and control of motor actions. Research is organized around three main topics ...more information

  • Neurodegenerative Diseases

    Genetics and Epigenetics of Neurodegeneration

    The recent advances in high-throughput genomic technologies have provided an unprecedented amount of genotype, expression and epigenetic data for many human disorders. ...more information

  • Cognitive Neurology

    Section for Neuropsychology

    The Section for Neuropsychology focuses on the investigation of spatial cognition and object recognition in humans. The current issues of our work comprise the action control and sensorimotor coordination ...more information

  • Neurodegenerative Diseases

    Functional Neurogenetics

    Age-related neurodegenerative diseases are a severe and increasingly worrisome burden for our aging population. Most of the chronic neurodegenerative diseases ...more information

  • Independent Research Groups

    Learning and Memory

    All organisms continuously have to adapt their behavior according to changes in the environment in order to survive. This is particularly important when learning to predict threatening or dangerous situations. ...more information

  • Cognitive Neurology

    Systems Neurophysiology Lab

    The overarching goal of our work is to understand the operating principles of the neocortex, a unique brain structure, which mainly evolved in mammals. There is clear evidence that the neocortex, in the broadest sense, endows the subject with cognitive capabilities. ...more information

  • Neurodegenerative Diseases

    Deep Brain Stimulation

    The working group aims to uncover mechanisms of action of deep brain stimulation therapy and to translate the pathophysiological insights into future developments. …more information

  • Cognitive Neurology

    Motor Control Modeling

    The research group „Multi-Level Modeling in Motor Control and Rehabilitation Robotics“ focuses on the generation and control of active biological movements. We develop ...more information

Events
-Das Gehirn der Zukunft - KI & Ethik
Speakers:
Prof. Dr. Regina Ammicht-Quinn (University of Tübingen)
Prof. Dr. Markus Frings (Evang. Klinikum Niederrhein)
Dr. Christoph Peylo (Robert Bosch GmbH)
Prof. Dr. Michael Sedlmair (University of Stuttgart)

Presentation: Carsten Knop (FAZ)

6 pm
Location: University of Stuttgart, M 17.02 Tiefenhörsaal

More infos: www.ghst.de/GehirnDerZukunft (in German only)
-Neurocolloquium - Attempto Awardees 2019 18:15 Svenja Brodt (Medical Psychology and Behavioral Neurobiology)
DW-MRI reveals rapid formation of memory engrams in the neocortex
19:00 Anuck Sawangjit (Medical Psychology and Behavioral Neuropsychology)
The hippocampus is crucial for forming long-term memory during sleep
Location: Children´s Hospital, Hoppe-Seyler-Str. 1, Ebene C3, Großer Hörsaal
-Neurocolloquium - Center for Mental Health Lecture 18:15 Alkomiet Hasan (Klinik für Psychiatrie und Psychotherapie, LMU München)
Non-invasive transcranial brain stimulation in psychiatry: basic and clinical research
Location: Children Hospital, Hoppe-Seyler-Str. 1, 3rd Floor, Lecture Hall

Combining excellent research and patient care

Click on the image to watch the video

An exemplary connection between research and clinical care

The German Council of Science and Humanities recognizes the performance and academic excellence of theHertie Institute for Clinical Brain Research. The recommendation of the council is an excellent basis for the further development of the HIH. 

Press release by the German Council of Science and Humanities (Wissenschaftsrat)

Press release by the HIH