Laying the foundations for tomorrow's medicine

News

  • An immunological memory in the brain

    Inflammatory reactions can change the brain’s immune cells in the long term – meaning that these cells have an ‘immunological memory’. This memory may influence the progression of neurological disorders that occur later in life, and is therefore a previously unknown factor that could influence the severity of these diseases. Scientists at the German Center for Neurodegenerative Diseases (DZNE), the Hertie Institute for Clinical Brain Research (HIH), and the University of Tübingen report on this in the journal “Nature”. Their study is the result of a collaborative effort also involving researchers from Göttingen, Bonn, and Freiburg.

    ... more info

  • World Parkinson’s Disease Day

    April 11th is World Parkinson's Disease Day. The day marks the birthday of James Parkinson, who first described the disease - which was later named after him - in 1817. After Alzheimer's disease, Parkinson's disease is the second most common neurodegenerative disease. While it affects around 4.1 million people worldwide, there are about 250,000 to 280,000 patients in Germany. 

    HIH director Professor Dr. Thomas Gasser reports on the history and research of Parkinson's disease in a lecture.

    Link to the video (in German)

  • Getting to the roots of a rare disease

    February 28 is Rare Disease Day 2018. The hereditary spastic paraplegia (HSP) is a rare neurological disease that leads to an increasing loss of motor neurons. Over the years, the patients lose the ability to walk. A new treatment strategy for a particular subtype of the disease – the spastic paraplegia gene type 5 (SPG5) – has been recently reported by scientists at the Hertie Institute for Clinical Brain Research, the University and the University Hospital Tübingen, and the German Center for Neurodegenerative Diseases. In the worldwide largest patient study so far, they observed that the cholesterol-lowering agent Atorvastatin reduces the concentration of the metabolite 27-hydroxycholesterol by about 30 percent in the blood. The metabolite has been shown to be elevated in patients and plays an important role in the pathogenesis of the disease. “This is the first causal treatment strategy for patients with SPG5,” says neurologist and first author Professor Dr. Ludger Schöls.

    ...more info (in German only)

  • Tübingen brain researchers receive Eva Luise Köhler Forschungspreis für Seltene Erkrankungen 2018

    On February 20, 2018, Dr. Ulrike Hedrich-Klimosch and her colleagues at the Hertie Institute for Clinical Brain Research and the University and the University Hospital Tübingen were awarded with this year’s Eva Luise Köhler Forschungspreis für Seltene Erkrankungen. The research team studies a rare and severe genetic form of epilepsy. The prize money of € 50,000 will serve the development of a drug therapy for affected patients whose disorder is based on a mutation in the KCNA2 gene. Until today, this form of epilepsy cannot be treated with the usual drugs. However, an active pharmaceutical ingredient - that has been approved for a different disorder - showed promising results in individual treatment attempts. It targets specifically potassium channels, which are genetically modified in the patients. The present approach might establish the first drug therapy for those affected, as the scientists report.

    ...more info (in German only)

  • Reactive oxygen species: bad guys also do good jobs

    Cellular aging, cancer, Parkinson's and Alzheimer's disease – these are the associations we usually get when we hear the term reactive oxygen species or ROS. However, the molecules seem to have a positive function as well: In nerve and spinal injuries, they play an indispensable role in the healing process. This is reported by an international team of researchers headed by Professor Dr. Simone Di Giovanni from Imperial College London in the UK and the Hertie Institute for Clinical Brain Research, the University of Tübingen. In the current issue of Nature Cell Biology, the researchers describe how injured nerve cells specifically incorporate an enzyme that produces reactive oxygen species. The ROS then initiate cellular processes that support nerve regeneration. “Popular types of treatment aiming at limiting the ROS production could actually be detrimental after nerve injury,” says Di Giovanni. “An appropriate timing and dose should be taken into account.” 

    more info (in German only)

Departments

  • Neurology and Stroke

    The Department of Neurology and Stroke has the main focuses in neurovascular medicine (vessel diseases of the brain, cerebral stroke), neuro-oncology (brain tumors, brain metastases), neuro-immunology (e.g., multiple sclerosis) and neuro-intensive medicine. ...more information

  • Neurodegenerative Diseases

    The Department of Neurodegenerative Diseases treats in-patients on a ward of about 20 beds and in several out-patient clinics. The clinical focus lies on neurodegenerative diseases such as Parkinson’s disease, the ataxias, spastic paraplegias, and dementias. ...more information

  • Neurology and Epileptology

    The Department of Neurology and Epileptology has a focus on epilepsy and other paroxysmal neurological disorders. In these diseases, the excitability of nerve cells temporarily changes either due to genetic or acquired defects. ...more information

  • Cognitive Neurology

    The Department of Cognitive Neurology provides consultant and outpatient neuropsychological care. Another clinical focus is the treatment of chronic dizziness in the interdisciplinary dizziness center “Südwestdeutsches Schwindelzentrum” operated in conjunction ..more information

  • Cellular Neurology

    The focus of the Department of Cellular Neurology lies on cellular and molecular mechanisms in the aging brain and age-related neurodegenerative diseases. Special emphasis is placed on Alzheimer's disease, the most common and severe form of senile dementia. ...more information

  • Independent Research Groups

    There are two independent research group at the HIH. One of their research focus is the molecular and cellular mechanisms of axon regeneration and neuronal differentiation during repair after damage to the central nervous system (CNS). A second research focus comprises ...more information

Research groups

  • Neurology and Stroke

    Brain Networks and Plasticity

    The human brain possesses the remarkable capacity of reorganization, which is the basis for adapting to constantly changing environmental conditions. This plasticity is of paramount importance ...more information

  • Cognitive Neurology

    Neuropsychology of Action

    The Research Group "Neuropsychology of Action" is dedicated to investigations of human action control. We study clinical impairments of action control and their neural substrates in patients with brain damage ...more information

  • Cellular Neurology

    Experimental Neuroimmunology

    An immune response is part of most neurological diseases, and the development of late-onset Alzheimer's Disease (AD) has been linked to immune related genes and most recently also to epigenetic modifications. ...more information

  • Neurodegenerative Diseases

    Genetics of Parkinson's disease

    Parkinson's syndrome (PS) is the second most common neurodegenerative disease after Alzheimer's dementia. The vast majority of patients are ill with no apparent cause. ...more information

  • Cellular Neurology

    Section for Dementia Research

    The Section for Dementia Research of the Department of Cellular Neurology and the University Clinic for Psychiatry and Psychotherapy is headed by Prof. Dr. Christoph Laske. The section consists ...more information

  • Neurology and Epileptology

    Clinical Genetics of Paroxysmal Neurological Diseases

    Paroxysmal neurological disorders include a broad spectrum of clinical entities such as migraine, episodic ataxia or myotonia. The research group is focussed on the clinical genetics ...more information

  • Cognitive Neurology

    Neuro-Vestibular Diagnostics

    The complaint of dizziness is highly prevalent but remains often an enigma to the physician in daily practice. Serious diseases potentially accompanied by dizziness like stroke, multiple sclerosis ...more information

  • Cognitive Neurology

    Oculomotor Laboratory

    Playing video-games is a widely distributed leisure activity in our society. In order to estimate the consequences of video-game play, we study the details of eye movements and pupil light responses ... more information

  • Cellular Neurology

    Experimental Neuropathology

    Cerebral proteopathy is a unifying term for cerebral neurodegenerative diseases in which aggregated proteins are abnormally deposited in the brain. The hallmark proteopathy is Alzheimer's disease (AD) ...more information

  • Independent Research Groups

    Neuroregeneration

    Our research focuses on the molecular and cellular mechanisms of axon regeneration and neuronal differentiation for the repair of central nervous system (CNS) damage, with particular emphasis ...more information

  • Neurodegenerative Diseases

    Functional Neurogenomics

    Neurodegenerative disorders are associated in a proportion of cases with genetic risk and gene mutations. However, the vast majority of cases of Parkinson’s disease are sporadic and the disease is altogether heterogeneous in symptoms and pathology. ...more information

Research groups

  • Neurodegenerative Diseases

    Clinical Neurodegeneration

    Parkinson's disease (PD) is the second most frequent neurodegenerative disorder after Alzheimer’s disease and affects about 1 to 2 % of individuals over the age of 65. The number is steadily increasing due to demographic changes in Western countries. ...more information

  • Cellular Neurology

    Molecular Imaging

    The Molecular Imaging group focuses on the visualization of Alzheimer's disease (AD) related changes in the brain of mouse models using in vivo multiphoton microscopy. A solid knowledge of the dynamics of amyloid lesions and ...more information

  • Neurology and Stroke

    Molecular Neurooncology

    Three to five of 100.000 people are annually diagnosed with a glioblastoma (GBM), the most malignant brain tumor in adults. Despite aggressive multimodal treatment including surgical resection and ...more information

  • Cognitive Neurology

    Neurobiology of Sensorimotor Decision Making

    Given the vast number of behavioral options that are usually available in an everyday life situation, how do we - and thus our brain - decide which option to go for ...more information

  • Neurodegenerative Diseases

    Functional Neurogeriatrics

    Die Forschungsgruppe funktionelle Neurogeriatrie untersucht motorische Funktionseinschränkungen bei Älteren und Patienten mit neurodegenerativen Erkrankungen. Es kommen dabei modernste Detektionssysteme ...more information

  • Cellular Neurology

    Fluid Disease Biomarkers

    Processes related to Alzheimer ́s disease (AD) and other age-related neurodegenerative diseases start many years before the onset of the first clinical symptoms. At the moment of the first clinical complaints, the disease has already caused ...more information

  • Neurology and Stroke

    Interdisciplinary Section of Neuro-Oncology

    The projects of the lab are focusing on the biology of brain tumors, especially with targeted individualized therapies, molecular mechanisms in the development of resistance and cell based therapy approaches ...more information

  • Neurology and Epileptology

    Translational Imaging

    The focus of our research group is the structural and functional imaging of neurological diseases with a particular focus on epileptology. We use multi-modal imaging techniques to improve the understanding of disease development ...more information

  • Neurodegenerative Diseases

    Dystonia

    Dystonia is the third most common movement disorder, and mutations in a growing number of genes have been identified as causes for hereditary forms in many cases. The aim of the group, which brings together clinical experience ...more information

  • Neurology and Stroke

    Neurophonetics and Translational Neurorehabilitation

    The work group Neurophonetics and Translational Neurorehabilitation is based on a cooperation between the University of Tübingen and a neurological rehabilitation clinic (Fachkliniken Hohenurach). ...more information

  • Neurology and Stroke

    Stroke and Neuroprotection

    The research focus of our Stroke and Neuroprotection Laboratory is to find new and to optimize existing neuroprotective strategies ...more information

  • Neurology and Epileptology

    Experimental Epileptology

    Our research group is interested to unravel the mechanisms of well defined, mainly genetic, neurological, paroxysmal diseases, to understand correlations with clinical symptoms and to find new treatment options. ...more information

Research groups

  • Neurology and Epileptology

    Migraines and Primary Headache Disorders

    Our group aims at unraveling the molecular pathophysiology of migraine and other primary headache disorders. ...more information

  • Neurodegenerative Diseases

    Section for Clinical Neurogenetics

    Neurogenetic diseases like cerebellar ataxia, hereditary spastic paraplegia and leukodystrophy are rare disorders. ...more information

  • Neurodegenerative Diseases

    Systems Neurodegeneration

    Our research focuses on the investigation of the genetic basis, systems neuroscience and paradigmatic therapy approaches in ...more information

  • Cognitive Neurology

    Sensorimotor Lab

    The lab addresses a variety of topics that, at first glance, may look disparate. Yet, there is a common denominator ...more information

  • Neurodegenerative Diseases

    Genomic of Rare Movement Disorders

    Our group specializes in rare diseases. A disease is called rare, when it affects no more than 5 of 100,000 people. However, in the grand-scheme of things, rare diseases are not quite so rare ...more information

  • Cognitive Neurology

    Section for Computational Sensomotorics

    The Section for Computational Sensomotorics investigates theoretical principles in the perception and control of motor actions. Research is organized around three main topics ...more information

  • Neurodegenerative Diseases

    Genetics and Epigenetics of Neurodegeneration

    The recent advances in high-throughput genomic technologies have provided an unprecedented amount of genotype, expression and epigenetic data for many human disorders. ...more information

  • Cognitive Neurology

    Section for Neuropsychology

    The Section for Neuropsychology focuses on the investigation of spatial cognition and object recognition in humans. The current issues of our work comprise the action control and sensorimotor coordination ...more information

  • Cellular Neurology

    Amyloid Biology

    The group studies mechanisms of amyloid formation in particular the molecular nature of pathogenic protein aggregation. ...more information

  • Neurodegenerative Diseases

    Functional Neurogenetics

    Age-related neurodegenerative diseases are a severe and increasingly worrisome burden for our aging population. Most of the chronic neurodegenerative diseases ...more information

  • Independent Research Groups

    Learning and Memory

    All organisms continuously have to adapt their behavior according to changes in the environment in order to survive. This is particularly important when learning to predict threatening or dangerous situations. ...more information

  • Cognitive Neurology

    Systems Neurophysiology Lab

    The overarching goal of our work is to understand the operating principles of the neocortex, a unique brain structure, which mainly evolved in mammals. There is clear evidence that the neocortex, in the broadest sense, endows the subject with cognitive capabilities. ...more information

  • Neurodegenerative Diseases

    Deep Brain Stimulation

    The working group aims to uncover mechanisms of action of deep brain stimulation therapy and to translate the pathophysiological insights into future developments. …more information

  • Cognitive Neurology

    Motor Control Modeling

    The research group „Multi-Level Modeling in Motor Control and Rehabilitation Robotics“ focuses on the generation and control of active biological movements. We develop ...more information

FAZ "Das Zittern hat eine Geschichte" (17.05.2017)
Press article by Prof. Dr. Thomas Gasser (in German)

FAZ "Warum wir Alzheimer immer noch nicht heilen können" (01.02.2017)
Press article by Prof. Dr. Mathias Jucker (in German)

Events
-Wissenschaftliches Kolloquium 17:00 Dr. Sven Poli, Oberarzt Neurologie mit Schwerpunkt Vaskuläre Erkrankungen
Stroke-Versorgung im Rahmen des neuen Dienstmodells
Raum B-04-221 (CRONA)
-Neurocolloquium 18:15 Daniel Huber (Département des neurosciences fondamentales, Université de Genève)
Natural and artificial channels for sensory perception
Ort: Kinderklinik, Hoppe-Seyler-Str. 1, Ebene C3, Großer Hörsaal
-Hertie Lunch Seminar 13:00 Jorge Garcia Morato, Neurodegenerative Diseases, Group Kahle
Role of acetylation in the (patho)physiology of TDP-43

13:30 Til Ole Bergmann, Vascular Neurology, Group Ziemann
EEG-triggered Transcranial Magnetic Stimulation to Study Neuronal Oscillations

Location: Hertie Seminar Room 2.310

An exemplary connection between research and clinical care

The German Council of Science and Humanities recognizes the performance and academic excellence of theHertie Institute for Clinical Brain Research. The recommendation of the council is an excellent basis for the further development of the HIH. 

Press release by the German Council of Science and Humanities (Wissenschaftsrat)

Press release by the HIH