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Laying the foundations for tomorrow's medicine

News

  • Two HIH neuroscientists receive Attempto Award 2018

    The Attempto Award of the Tübingen Attempto Foundation will go to two young scientists at the HIH this year. They are each endowed with 10,000 Euros.

    Dr. Leonid Fedorov is honored for his work on the representation of social actions in the brain. His experiments showed that the neural processes responsible for recognizing individual actions (such as to give) are also activated by the counterpart (here: to take). The result may be interesting for the study of social disorders such as autism but also for robotics. 

    Ann-Christin Wendeln is honored for her publication on the influence of the immune memory in the brain on neurological disorders. She showed that inflammatory reactions can change microglia in the brain over the long term. The cells thus possess an ‘immunological memory’, that may influence the course of later occurring neurological diseases.

     

     

  • Sensory perception is not a one-way street

    When we interact with the world, such as when we reach out to touch an object, the brain actively changes incoming sensory signals based on anticipation. This so-called ‘sensory gating’ has now been investigated by neuroscientists at the HIH and the Werner Reichardt Centre for Integrative Neuroscienceat the University of Tübingen. In rats touching objects with their whiskers, they found that these touch signals from active sensory perception were reduced by gating signals from higher brain areas. This way, sensory perception may be shaped by expectations generated in the higher brain. Such anticipatory signals could have important implications in understanding sensory hallucinations such as those encountered in schizophrenia. The study has been published in Nature Communications.

    ... more info

  • New independent research group at the HIH

    How do messenger substances, so-called neurotransmitters, control the development and evolution of the cerebral cortex? This is the question Dr. Simone Mayer addresses in her research. Since September 2018 she heads the independent research group “Molecular Brain Development” at the HIH. In her work, she compares various mammalian species and uses a variety of cell biological, biochemical and bioinformatic methods. In addition to the basic mechanisms, she is interested in how disorders in these messenger systems may promote brain diseases. “Neocortical networks are at the heart of human cognition, but their high complexity may have contributed to the evolutionary emergence of various psychiatric and neurological disorders,” explains Mayer. Since neurotransmitters are targeted by various drugs, her research also sheds light on the risk and potential to influence brain development during pregnancy.

    ... read more about her research group

  • Being spoiled for choice – what happens in the human brain

    Who has not faced this situation? Having too many choices when shopping for a product creates a feeling that we call “being spoiled for choice.” Academic studies have proven for some time that consumers find a large selection of products attractive, but this makes it increasingly difficult for them to decide what to buy. A team centered on the Tübingen scientist, Dr. Axel Lindner, from the University Hospital for Psychiatry and Psychotherapy and the Hertie Institute for Clinical Brain Research has now discovered what takes place in our brains when we are “spoiled for choice.” The brain activity in particular areas was always strongest when people were confronted with the preferred mid-level number of options. If the number becomes too large, the cognitive effort involved in making a decision exceeds the benefits – brain activity declines and we face a “spoiled for choice” situation. The current findings are published in the current issue of Nature Human Behaviour.

    ... more info

  • "Beware, that went wrong last time"

    From left to right, from top to bottom: when we move our eyes, small deviations can occur even in such simple tasks. A research team led by Professor Peter Thier and Marc Junker at the Hertie Institute for Clinical Brain Research and the Werner Reichardt Center for Integrative Neurosciences (CIN) at the University of Tübingen now report brain signals that point to these errors. They are sent out by nerve cells in the cerebellum, just before we repeat an eye movement. The signal allows us to adapt the movement and to learn. With the study, the researchers clarify the function of the so-called climbing fiber signal, which was previously controversial. The results have been published in the current issue of the journal PLOS Biology.

    ... more info (in German only)

     

    Image: Fahad Sultan

Departments

  • Neurology and Stroke

    The Department of Neurology and Stroke has the main focuses in neurovascular medicine (vessel diseases of the brain, cerebral stroke), neuro-oncology (brain tumors, brain metastases), neuro-immunology (e.g., multiple sclerosis) and neuro-intensive medicine. ...more information

  • Neurodegenerative Diseases

    The Department of Neurodegenerative Diseases treats in-patients on a ward of about 20 beds and in several out-patient clinics. The clinical focus lies on neurodegenerative diseases such as Parkinson’s disease, the ataxias, spastic paraplegias, and dementias. ...more information

  • Neurology and Epileptology

    The Department of Neurology and Epileptology has a focus on epilepsy and other paroxysmal neurological disorders. In these diseases, the excitability of nerve cells temporarily changes either due to genetic or acquired defects. ...more information

  • Cognitive Neurology

    The Department of Cognitive Neurology provides consultant and outpatient neuropsychological care. Another clinical focus is the treatment of chronic dizziness in the interdisciplinary dizziness center “Südwestdeutsches Schwindelzentrum” operated in conjunction ..more information

  • Cellular Neurology

    The focus of the Department of Cellular Neurology lies on cellular and molecular mechanisms in the aging brain and age-related neurodegenerative diseases. Special emphasis is placed on Alzheimer's disease, the most common and severe form of senile dementia. ...more information

  • Independent Research Groups

    The independent research group at the HIH focuses on the physiology of learning and memory ...more information

Research groups

  • Neurology and Stroke

    Brain Networks and Plasticity

    The human brain possesses the remarkable capacity of reorganization, which is the basis for adapting to constantly changing environmental conditions. This plasticity is of paramount importance ...more information

  • Cognitive Neurology

    Neuropsychology of Action

    The Research Group "Neuropsychology of Action" is dedicated to investigations of human action control. We study clinical impairments of action control and their neural substrates in patients with brain damage ...more information

  • Cellular Neurology

    Experimental Neuroimmunology

    An immune response is part of most neurological diseases, and the development of late-onset Alzheimer's Disease (AD) has been linked to immune related genes and most recently also to epigenetic modifications. ...more information

  • Neurodegenerative Diseases

    Genetics of Parkinson's disease

    Parkinson's syndrome (PS) is the second most common neurodegenerative disease after Alzheimer's dementia. The vast majority of patients are ill with no apparent cause. ...more information

  • Cellular Neurology

    Section for Dementia Research

    The Section for Dementia Research of the Department of Cellular Neurology and the University Clinic for Psychiatry and Psychotherapy is headed by Prof. Dr. Christoph Laske. The section consists ...more information

  • Neurology and Epileptology

    Clinical Genetics of Paroxysmal Neurological Diseases

    Paroxysmal neurological disorders include a broad spectrum of clinical entities such as migraine, episodic ataxia or myotonia. The research group is focussed on the clinical genetics ...more information

  • Cognitive Neurology

    Neuro-Vestibular Diagnostics

    The complaint of dizziness is highly prevalent but remains often an enigma to the physician in daily practice. Serious diseases potentially accompanied by dizziness like stroke, multiple sclerosis ...more information

  • Cognitive Neurology

    Oculomotor Laboratory

    Playing video-games is a widely distributed leisure activity in our society. In order to estimate the consequences of video-game play, we study the details of eye movements and pupil light responses ... more information

  • Cellular Neurology

    Experimental Neuropathology

    Cerebral proteopathy is a unifying term for cerebral neurodegenerative diseases in which aggregated proteins are abnormally deposited in the brain. The hallmark proteopathy is Alzheimer's disease (AD) ...more information

  • Neurodegenerative Diseases

    Functional Neurogenomics

    Neurodegenerative disorders are associated in a proportion of cases with genetic risk and gene mutations. However, the vast majority of cases of Parkinson’s disease are sporadic and the disease is altogether heterogeneous in symptoms and pathology. ...more information

  • Independent Research Group

    Molecular Brain Development

    The mammalian neocortex is a highly complex and spatially heterogeneous structure, which has expanded significantly in mammalian evolution. Neocortical network function is at the heart of cognitive function ...more info

Research groups

  • Neurodegenerative Diseases

    Clinical Neurodegeneration

    Parkinson's disease (PD) is the second most frequent neurodegenerative disorder after Alzheimer’s disease and affects about 1 to 2 % of individuals over the age of 65. The number is steadily increasing due to demographic changes in Western countries. ...more information

  • Cellular Neurology

    Molecular Imaging

    The Molecular Imaging group focuses on the visualization of Alzheimer's disease (AD) related changes in the brain of mouse models using in vivo multiphoton microscopy. A solid knowledge of the dynamics of amyloid lesions and ...more information

  • Neurology and Stroke

    Molecular Neurooncology

    Three to five of 100.000 people are annually diagnosed with a glioblastoma (GBM), the most malignant brain tumor in adults. Despite aggressive multimodal treatment including surgical resection and ...more information

  • Cognitive Neurology

    Neurobiology of Sensorimotor Decision Making

    Given the vast number of behavioral options that are usually available in an everyday life situation, how do we - and thus our brain - decide which option to go for ...more information

  • Cellular Neurology

    Fluid Disease Biomarkers

    Processes related to Alzheimer ́s disease (AD) and other age-related neurodegenerative diseases start many years before the onset of the first clinical symptoms. At the moment of the first clinical complaints, the disease has already caused ...more information

  • Neurology and Stroke

    Interdisciplinary Section of Neuro-Oncology

    The projects of the lab are focusing on the biology of brain tumors, especially with targeted individualized therapies, molecular mechanisms in the development of resistance and cell based therapy approaches ...more information

  • Neurology and Epileptology

    Translational Imaging

    The focus of our research group is the structural and functional imaging of neurological diseases with a particular focus on epileptology. We use multi-modal imaging techniques to improve the understanding of disease development ...more information

  • Neurodegenerative Diseases

    Dystonia

    Dystonia is the third most common movement disorder, and mutations in a growing number of genes have been identified as causes for hereditary forms in many cases. The aim of the group, which brings together clinical experience ...more information

  • Neurology and Stroke

    Neurophonetics and Translational Neurorehabilitation

    The work group Neurophonetics and Translational Neurorehabilitation is based on a cooperation between the University of Tübingen and a neurological rehabilitation clinic (Fachkliniken Hohenurach). ...more information

  • Neurology and Stroke

    Stroke and Neuroprotection

    The research focus of our Stroke and Neuroprotection Laboratory is to find new and to optimize existing neuroprotective strategies ...more information

  • Neurology and Epileptology

    Experimental Epileptology

    Our research group is interested to unravel the mechanisms of well defined, mainly genetic, neurological, paroxysmal diseases, to understand correlations with clinical symptoms and to find new treatment options. ...more information

  • Cognitive Neurology

    Active Perception Lab

    Humans are tremendously reliant on the sense of vision to interact with their environment. Such interaction often involves the generation of motor outputs ...more information

  • Neurodegenerative Diseases

    Mitochondrial Biology of Parkinson’s Disease

    Neurodegenerative disorders are associated in a proportion of cases with genetic risk and gene mutations. However, the vast majority …more info

Research groups

  • Neurology and Epileptology

    Migraines and Primary Headache Disorders

    Our group aims at unraveling the molecular pathophysiology of migraine and other primary headache disorders. ...more information

  • Neurodegenerative Diseases

    Section for Clinical Neurogenetics

    Neurogenetic diseases like cerebellar ataxia, hereditary spastic paraplegia and leukodystrophy are rare disorders. ...more information

  • Neurodegenerative Diseases

    Systems Neurodegeneration

    Our research focuses on the investigation of the genetic basis, systems neuroscience and paradigmatic therapy approaches in ...more information

  • Cognitive Neurology

    Sensorimotor Lab

    The lab addresses a variety of topics that, at first glance, may look disparate. Yet, there is a common denominator ...more information

  • Neurodegenerative Diseases

    Genomic of Rare Movement Disorders

    Our group specializes in rare diseases. A disease is called rare, when it affects no more than 5 of 100,000 people. However, in the grand-scheme of things, rare diseases are not quite so rare ...more information

  • Cognitive Neurology

    Section for Computational Sensomotorics

    The Section for Computational Sensomotorics investigates theoretical principles in the perception and control of motor actions. Research is organized around three main topics ...more information

  • Neurodegenerative Diseases

    Genetics and Epigenetics of Neurodegeneration

    The recent advances in high-throughput genomic technologies have provided an unprecedented amount of genotype, expression and epigenetic data for many human disorders. ...more information

  • Cognitive Neurology

    Section for Neuropsychology

    The Section for Neuropsychology focuses on the investigation of spatial cognition and object recognition in humans. The current issues of our work comprise the action control and sensorimotor coordination ...more information

  • Cellular Neurology

    Amyloid Biology

    The group studies mechanisms of amyloid formation in particular the molecular nature of pathogenic protein aggregation. ...more information

  • Neurodegenerative Diseases

    Functional Neurogenetics

    Age-related neurodegenerative diseases are a severe and increasingly worrisome burden for our aging population. Most of the chronic neurodegenerative diseases ...more information

  • Independent Research Groups

    Learning and Memory

    All organisms continuously have to adapt their behavior according to changes in the environment in order to survive. This is particularly important when learning to predict threatening or dangerous situations. ...more information

  • Cognitive Neurology

    Systems Neurophysiology Lab

    The overarching goal of our work is to understand the operating principles of the neocortex, a unique brain structure, which mainly evolved in mammals. There is clear evidence that the neocortex, in the broadest sense, endows the subject with cognitive capabilities. ...more information

  • Neurodegenerative Diseases

    Deep Brain Stimulation

    The working group aims to uncover mechanisms of action of deep brain stimulation therapy and to translate the pathophysiological insights into future developments. …more information

  • Cognitive Neurology

    Motor Control Modeling

    The research group „Multi-Level Modeling in Motor Control and Rehabilitation Robotics“ focuses on the generation and control of active biological movements. We develop ...more information

FAZ "Das Zittern hat eine Geschichte" (17.05.2017)
Press article by Prof. Dr. Thomas Gasser (in German)

FAZ "Warum wir Alzheimer immer noch nicht heilen können" (01.02.2017)
Press article by Prof. Dr. Mathias Jucker (in German)

Events
-Wissenschaftliches Kolloquium der Neurologischen Klinik

17:00 h

Location: CRONA Kursraum 420-4-221

Programm

-Neurocolloquium - GTC Students' Favourites 18:15 h Marcelo Magnasco (Lab. of Integrative Neuroscience, Rockefeller Univ., New York)
Critical dynamics and flexible control of neural activity
Location: CRONA, Hoppe-Seyler-Str. 3, Floor 4, Lecture Hall B04-210
-Neurobiologisches Montagskolloquium 18:00 h Greg Schwartz (DDepartments of Ophthalmology and Physiology, Northwestern University, Chicago)
New functions for electrical synapses in the retina
Location: HIH, Seminar Room 2.310

An exemplary connection between research and clinical care

The German Council of Science and Humanities recognizes the performance and academic excellence of theHertie Institute for Clinical Brain Research. The recommendation of the council is an excellent basis for the further development of the HIH. 

Press release by the German Council of Science and Humanities (Wissenschaftsrat)

Press release by the HIH