Laying the foundations for tomorrow's medicine

News

  • World Brain Day: HIH researchers examine blood coagulation testing devices for a more efficient stroke treatment

    “Stroke is a brain attack – prevent it and treat it” – this is the motto of  this year´s World Brain Day on July 22. Dr. Sven Poli from the Department of Neurology with Neurovascular Medicine and Neuro-Oncology investigates new strategies to minimize brain damage after stroke. His research group is currently analyzing novel devices for rapid coagulation testing in patients on direct oral anticoagulants. These drugs are used for stroke prevention in high-risk patients. In case of an acute stroke, however, the attending physician must be aware of the drug concentration in the blood. Depending on the detected level of anticoagulation, he will initialize different treatment strategies. According to Poli, the devices reliably measured the concentration of one of these drugs. The neurologist is now examining devices for rapid coagulation testing in patients on other antithrombotics. “The results will contribute to a faster and thus more efficient treatment of the patient group,” explains Poli. 

  • A conference on tumors of the brain membranes

    “From Basic Science to Clinical Strategies”: this is the motto of the second International Meningeom Meeting (IMM) which will take place in Tübingen from September 2 – 3, 2017. According to co-organizer and head of the HIH research group "Clinical and Experimental Neuro-Oncology", Prof. Dr. Dr. Ghazaleh Tabatabai, there will be an exciting and broad scientific program: “The topics range from tumor biology and neuropathology, imaging, radiotherapy and surgical perspectives to systemic drug therapy and clinical studies in meningioma.” Interested participants may submit an abstract until July 15, 2017.

    Further information can be obtained on the website of the conference.

  • Alzheimer therapy: Early protein seeds are most potent

    In Alzheimer's disease, large amounts of the protein beta-amyloid aggregate in the brain. Folded differently than in the native state, it may not be decomposed. Notably, the protein initiates and drives its own deposition: reminding of a falling raw of dominoes, seeds of misfolded beta-amyloid recruit healthy proteins into the misfolded state.

    Lan Ye and Jay Rasmussen at the Hertie Institute for Clinical Brain Research now show that early misfolded protein seeds are particularly potent. Later, the seeding activity decreases. “This finding underscores the need for therapeutic intervention targeting beta-amyloid at the very early stages of Alzheimer´s disease – long before aggregations can be detected by current diagnostic procedures,” explains study leader Professor Dr. Matthias Jucker. “In this light, more sensitive biomarkers are needed.” 

    ... more info

  • Prof. Dr. Hans-Jochen Heinze receives honorary doctorate from the Medical Faculty of Tübingen

    The Medical Faculty Tübingen has given an honorary doctorate to Professor Dr. Hans-Jochen Heinze in recognition of his merits for the scientific community in Tübingen. The award ceremony took place at the graduation ceremony on Friday July 7, 2017. In his laudation, Professor Dr. Thomas Gasser, appreciated Heinz's commitment to the Hertie Institute for Clinical Brain Research among others. Heinze is a long-standing member and current chairman of the Board of Trustees. “In the end it was also his practical and conceptual support that led to the successful evaluation of the HIH by the German Wissenschaftsrat in 2015,” Gasser said. This in turn has been a major milestone in the formation of the Translational Neuroscience Focus at the Medical Faculty Tübingen, he continues. 

    Image (from left to right): Prof. Dr. Autenrieth (dean of the Medical Faculty Tübingen), Prof. Dr. Hans-Jochen Heinze (honary doctor at the Medical Faculty Tübingen), Prof. Dr. Thomas Gasser (chairman of the HIH Board of Directors) 

  • Interdisciplinary Therapy Conference on Clinical Neurosciences

    From June 30 to July 1, the Interdisciplinary Therapy Conference on Clinical Neurosciences will take place in Tübingen. Conference coordinator is Prof. Dr. Dr. Ghazaleh Tabatabai, head of the research group “Clinical and Experimental Neuro-Oncology” at the Hertie Institute for Clinical Brain Research. In addition to current information from the clinics working in the field of neuroscience at the University Hospital Tübingen, lectures and workshops on topics such as deep brain stimulation, neurogenetics for clinical practice and neuro-oncology are offered. The conference aims at physicians in the field of neurosciences.

  • A March for Science

    On April 22, 2017, millions of researchers, students and citizens worldwide demonstrated for the freedom of science and research. In Tübingen, close to 3000 people took the streets for a free exchange between researchers and against „alternative facts“, narrow-mindedness and ignorance. With this number of participants, it has been the largest demonstration in the university town in many years. The march was organized by researchers from the various scientific institutions in Tübingen. Prof. Dr. Thomas Gasser, Chairman of the Board of directors at the HIH and Dr. Astrid Proksch, Administrative director of the HIH, were members of the organizing group. “Any constructive dialogue looses its basis if scientifically proven facts are denied, relativized, or put on a par with “alternative facts”. A free research is therefore the basis of our democracy and affects our society as a whole,” Gasser explains.

Departments

  • Neurology and Stroke

    The Department of Neurology and Stroke has the main focuses in neurovascular medicine (vessel diseases of the brain, cerebral stroke), neuro-oncology (brain tumors, brain metastases), neuro-immunology (e.g., multiple sclerosis) and neuro-intensive medicine. ...more information

  • Neurodegenerative Diseases

    The Department of Neurodegenerative Diseases treats in-patients on a ward of about 20 beds and in several out-patient clinics. The clinical focus lies on neurodegenerative diseases such as Parkinson’s disease, the ataxias, spastic paraplegias, and dementias. ...more information

  • Neurology and Epileptology

    The Department of Neurology and Epileptology has a focus on epilepsy and other paroxysmal neurological disorders. In these diseases, the excitability of nerve cells temporarily changes either due to genetic or acquired defects. ...more information

  • Cognitive Neurology

    The Department of Cognitive Neurology provides consultant and outpatient neuropsychological care. Another clinical focus is the treatment of chronic dizziness in the interdisciplinary dizziness center “Südwestdeutsches Schwindelzentrum” operated in conjunction ..more information

  • Cellular Neurology

    The focus of the Department of Cellular Neurology lies on cellular and molecular mechanisms in the aging brain and age-related neurodegenerative diseases. Special emphasis is placed on Alzheimer's disease, the most common and severe form of senile dementia. ...more information

  • Independent Research Groups

    There are two independent research group at the HIH. One of their research focus is the molecular and cellular mechanisms of axon regeneration and neuronal differentiation during repair after damage to the central nervous system (CNS). A second research focus comprises ...more information

Research groups

  • Neurology and Stroke

    Brain Networks and Plasticity

    Das menschliche Gehirn besitzt eine erstaunliche Fähigkeit zur Reorganisation, die Voraussetzung für die Anpassung an sich ständig ändernde Umweltbedingungen ist. Diese Fähigkeit zur Plastizität ...more information

  • Neurology and Epileptology

    Functional Neuronal Networks

    Neuronal network activity can be assessed by the microelectrode array (MEA) technology that allows simultaneous recording of the electrical activity exhibited by entire populations of neurons over several weeks or months in vitro. ...more information

  • Cognitive Neurology

    Neuropsychology of Action

    The Research Group "Neuropsychology of Action" is dedicated to investigations of human action control. We study clinical impairments of action control and their neural substrates in patients with brain damage ...more information

  • Cellular Neurology

    Experimental Neuroimmunology

    An immune response is part of most neurological diseases, and the development of late-onset Alzheimer's Disease (AD) has been linked to immune related genes and most recently also to epigenetic modifications. ...more information

  • Neurodegenerative Diseases

    Genetics of Parkinson's disease

    Parkinson's syndrome (PS) is the second most common neurodegenerative disease after Alzheimer's dementia. The vast majority of patients are ill with no apparent cause. ...more information

  • Cellular Neurology

    Section for Dementia Research

    The Section for Dementia Research of the Department of Cellular Neurology and the University Clinic for Psychiatry and Psychotherapy is headed by Prof. Dr. Christoph Laske. The section consists ...more information

  • Neurology and Stroke

    Neuroimmunology

    Our research group investigates the role of the immune system in inflammatory diseases of the central nervous system (CNS) and stroke. We are particularly interested in finding out which immune cells are ...more information

  • Neurology and Epileptology

    Clinical Genetics of Paroxysmal Neurological Diseases

    Der Überbegriff der paroxysmalen neurologischen Erkrankungen beinhaltet ein breites Spektrum an klinischen Entitäten mit episodischem Auftreten von Störungen des Nervensystems....more information

  • Cognitive Neurology

    Neuro-Vestibular Diagnostics

    The complaint of dizziness is highly prevalent but remains often an enigma to the physician in daily practice. Serious diseases potentially accompanied by dizziness like stroke, multiple sclerosis ...more information

  • Cognitive Neurology

    Oculomotor Laboratory

    Playing video-games is a widely distributed leisure activity in our society. In order to estimate the consequences of video-game play, we study the details of eye movements and pupil light responses ... more information

  • Cellular Neurology

    Experimental Neuropathology

    Cerebral proteopathy is a unifying term for cerebral neurodegenerative diseases in which aggregated proteins are abnormally deposited in the brain. The hallmark proteopathy is Alzheimer's disease (AD) ...more information

  • Independent Research Groups

    Neuroregeneration

    Our research focuses on the molecular and cellular mechanisms of axon regeneration and neuronal differentiation for the repair of central nervous system (CNS) damage, with particular emphasis ...more information

  • Neurodegenerative Diseases

    Functional Neurogenomics

    Neurodegenerative disorders are associated in a proportion of cases with genetic risk and gene mutations. However, the vast majority of cases of Parkinson’s disease are sporadic and the disease is altogether heterogeneous in symptoms and pathology. ...more information

Research groups

  • Neurodegenerative Diseases

    Clinical Neurodegeneration

    Die Forschungsgruppe "Klinische Neurodegeneration" befasst sich mit häufig vorkommenden neurodegenerativen Erkrankungen, v.a. der Parkinsonerkrankung und Demenzerkrankungen, die mit Bewegungsstörungen einhergehen. ...more information

  • Cellular Neurology

    Molecular Imaging

    The Molecular Imaging group focuses on the visualization of Alzheimer's disease (AD) related changes in the brain of mouse models using in vivo multiphoton microscopy. A solid knowledge of the dynamics of amyloid lesions and ...more information

  • Neurology and Stroke

    Molecular Neurooncology

    Three to five of 100.000 people are annually diagnosed with a glioblastoma (GBM), the most malignant brain tumor in adults. Despite aggressive multimodal treatment including surgical resection and ...more information

  • Neurology and Epileptology

    Functional Epilepsy Genetics

    Our research focus is on two ion channel groups with a prominent role in the regulation of excitability, the neuronal Kv7 channels and the GABA(A) receptors. A number of genetic alterations detected in recent years in the corresponding KCNQ2/3 ...more information

  • Cognitive Neurology

    Neurobiology of Sensorimotor Decision Making

    Given the vast number of behavioral options that are usually available in an everyday life situation, how do we - and thus our brain - decide which option to go for ...more information

  • Neurodegenerative Diseases

    Functional Neurogeriatrics

    Die Forschungsgruppe funktionelle Neurogeriatrie untersucht motorische Funktionseinschränkungen bei Älteren und Patienten mit neurodegenerativen Erkrankungen. Es kommen dabei modernste Detektionssysteme ...more information

  • Cellular Neurology

    Fluid Disease Biomarkers

    Processes related to Alzheimer ́s disease (AD) and other age-related neurodegenerative diseases start many years before the onset of the first clinical symptoms. At the moment of the first clinical complaints, the disease has already caused ...more information

  • Neurology and Stroke

    Clinical and Experimental Neurooncology

    Die Projekte des Labors für Klinische und Experimentelle Neuroonkologie befassen sich mit der Biologie von Hirntumoren, mit speziellem Fokus auf zielgerichteten individualisierten therapeutischen Angriffspunkten ...more information

  • Neurology and Epileptology

    Translational Imaging

    Der Schwerpunkt unserer Forschungsgruppe ist die strukturelle und funktionelle Bildgebung neurologischer Erkrankungen mit besonderem Fokus auf die Epileptologie. Wir nutzen die technischen Methoden multi-modaler Bildgebung ...more information

  • Neurodegenerative Diseases

    Dystonia

    Dystonia is the third most common movement disorder, and mutations in a growing number of genes have been identified as causes for hereditary forms in many cases. The aim of the group, which brings together clinical experience ...more information

  • Neurology and Stroke

    Neurophonetics and Translational Neurorehabilitation

    The work group Neurophonetics and Translational Neurorehabilitation is based on a cooperation between the Universitäty of Tübingen and a neurological rehabilitation clinic (Fachkliniken Hohenurach). ...more information

  • Neurology and Stroke

    Stroke and Neuroprotection

    The research focus of our Stroke and Neuroprotection Laboratory is to find new and to optimize existing neuroprotective strategies ...more information

  • Neurology and Epileptology

    Experimental Epileptology

    Our research group is interested to unravel the mechanisms of well defined, mainly genetic, neurological, paroxysmal diseases, to understand correlations with clinical symptoms and to find new treatment options. ...more information

Research groups

  • Neurology and Epileptology

    Migraines and Primary Headache Disorders

    Our group aims at unraveling the molecular pathophysiology of migraine and other primary headache disorders. ...more information

  • Neurodegenerative Diseases

    Section for Clinical Neurogenetics

    Neurogenetic diseases like cerebellar ataxia, hereditary spastic paraplegia and leukodystrophy are rare disorders. ...more information

  • Neurodegenerative Diseases

    Systems Neurodegeneration

    Our research focuses on the investigation of the genetic basis, systems neuroscience and paradigmatic therapy approaches in ...more information

  • Cognitive Neurology

    Sensorimotor Lab

    The lab addresses a variety of topics that, at first glance, may look disparate. Yet, there is a common denominator ...more information

  • Neurodegenerative Diseases

    Genomic of Rare Movement Disorders

    Our group specializes in rare diseases. A disease is called rare, when it affects no more than 5 of 100,000 people. However, in the grand-scheme of things, rare diseases are not quite so rare ...more information

  • Cognitive Neurology

    Section for Computational Sensomotorics

    The Section for Computational Sensomotorics investigates theoretical principles in the perception and control of motor actions. Research is organized around three main topics ...more information

  • Neurodegenerative Diseases

    Genetics and Epigenetics of Neurodegeneration

    The recent advances in high-throughput genomic technologies have provided an unprecedented amount of genotype, expression and epigenetic data for many human disorders. ...more information

  • Cognitive Neurology

    Section for Neuropsychology

    The Section for Neuropsychology focuses on the investigation of spatial cognition and object recognition in humans. The current issues of our work comprise the action control and sensorimotor coordination ...more information

  • Cellular Neurology

    Amyloid Biology

    The group studies mechanisms of amyloid formation in particular the molecular nature of pathogenic protein aggregation. ...more information

  • Neurodegenerative Diseases

    Functional Neurogenetics

    Age-related neurodegenerative diseases are a severe and increasingly worrisome burden for our aging population. Most of the chronic neurodegenerative diseases ...more information

  • Independent Research Groups

    Learning and Memory

    All organisms continuously have to adapt their behavior according to changes in the environment in order to survive. This is particularly important when learning to predict threatening or dangerous situations. ...more information

  • Cognitive Neurology

    Systems Neurophysiology Lab

    The overarching goal of our work is to understand the operating principles of the neocortex, a unique brain structure, which mainly evolved in mammals. There is clear evidence that the neocortex, in the broadest sense, endows the subject with cognitive capabilities. ...more information

  • Neurodegenerative Diseases

    Deep Brain Stimulation

    The working group aims to uncover mechanisms of action of deep brain stimulation therapy and to translate the pathophysiological insights into future developments. …more information

  • Cognitive Neurology

    Motor Control Modeling

    The research group „Multi-Level Modeling in Motor Control and Rehabilitation Robotics“ focuses on the generation and control of active biological movements. We develop ...more information

FAZ "Das Zittern hat eine Geschichte" (17.05.2017)
Press article by Prof. Dr. Thomas Gasser (in German)

FAZ "Warum wir Alzheimer immer noch nicht heilen können" (01.02.2017)
Press article by Prof. Dr. Mathias Jucker (in German)

Events
-Therapieseminar der Neurologischen Klinik 17:00 Klinisch-pathologische Fallkonferenz
Raum B-04-221 (CRONA)
-Neurocolloquium - Hertie Lecture 18:15 Kailash P. Bathia (Sobell Department, Institute of Neurology, University College London)
Neurodegeneration with brain accumulation disorders: genetic advances and their pathophysiological implications
Ort: Kinderklinik, Hoppe-Seyler-Str. 1, Ebene C3, Großer Hörsaal
-International Meningioma Meeting From Basic Science to Clinical Strategies

September 2-3, Tübingen

More information: http://meningioma-tuebingen.com

An exemplary connection between research and clinical care

The German Council of Science and Humanities recognizes the performance and academic excellence of theHertie Institute for Clinical Brain Research. The recommendation of the council is an excellent basis for the further development of the HIH. 

Press release by the German Council of Science and Humanities (Wissenschaftsrat)

Press release by the HIH