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Laying the foundations for tomorrow's medicine


  • Markus Siegel receives Consolidator Grant from the European Research Council

    The European Research Council (ERC) supports Professor Dr. Markus Siegel from HIH and the Werner Reichardt Center for Integrative Neuroscience with an ERC Consolidator Grant. Siegel and his team investigate the neuronal foundations of our thinking and acting in the project "Neuronal Information through Neuronal Interactions (NINI)". They combine the latest electrophysiological and analytical techniques to investigate how sensory, cognitive and motor information is generated in the brain and to what extent interactions between different nerve cell networks are involved. The ERC Consolidator Grant supports scientists with several years of research experience in building a career and their own research team.

    Please read the press release (in German only)

    Image: Foto: Verena Müller/UKT

  • Tübingen selected for excellent network of the Hertie Foundation

    Tübingen is one of six top research locations in Germany that are now being funded as part of the newly initiated "Hertie Network of Excellence in Clinical Neuroscience". The Hertie Foundation's network and junior researcher support programme, which is funded with five million euros, aims to facilitate the transfer of scientific findings into clinical practice in the field of clinical neurosciences. Over the next three years, a total of 660,000 euros will be invested in the Tübingen site, which will involve scientists from the Hertie Institute for Clinical Brain Research, the University of Tübingen and the German Centre for Neurodegenerative Diseases.

    Please read the complete press release (in German only) 

    Picture: Charitable Hertie Foundation / Photographer Jenna Dallwitz Berlin

  • Rare hereditary disease: a small messenger molecule shows great effect

    Brain researchers from Tübingen have developed a new approach for the treatment of hereditary spastic paraplegia (HSP). A gene therapy may treat the rare neurological disease directly at its point of origin. The therapeutic approach aims to treat the subtype spastic paraplegia gene type 5, or SPG5 in short. In this case, a defective gene leads to an increase of certain metabolic products in the brain that have a fatal effect on nerve cells. As a consequence, the affected patients lose their ability to walk in the long term. Now, the genetic defect has been able to be successfully circumvented for the first time in an animal model by repeatedly administering a messenger molecule (mRNA) into the blood. This led to a normalization of the concentration of neurotoxic metabolic products in the brain, reports an international research team led by Professor Schöls in collaboration with the company CureVac.

    Please read the complete press release (in German only)

  • HIH research team once again involved in a Synergy Grant

    Professor Martin Giese receives a "Synergy Grant" from the European Research Council (ERC). Together with colleagues at the KU Leuven and the University of Maastricht, he will investigate how our brain analyzes body language for non-verbal communication in the project "How body relevant drives brain organization" (RELEVANCE). "We hope that a better understanding of brain processes will contribute to improved systems for the simulation and analysis of body signals in the field of artificial intelligence and virtual reality," Giese explains. At the HIH he heads the Section for Computational Sensomotorics, which combines theoretical neuroscience with applications in biomedical technology. The ERC is funding the project for a period of five years with a total of eight million euros, of which around 2.7 million euros are earmarked for the work of the Tübingen team. The “Synergy Grants” are considered the most competitive applications in the prestigious funding program of the ERC. It was only last year that a HIH research team obtained a "Synergy Grant".

    Please read the press release (in German only)

  • Open Door Presentation at the HIH

    On October 13, 2019, the HIH Open Door Presentation gave an exciting insight into the world of clinical brain research. Numerous visitors followed the invitation. In a series of lectures, scientists presented the latest findings from research and therapy. The topics ranged from Parkinson's, Alzheimer's, epilepsy, stroke and dizziness to rare neurological diseases. At the same time, the visitors had the opportunity to get to know the work at the institute in guided tours. For example, they were able to examine nerves in the ultrasound device or learn about eye movements and movement therapy. The Open Door Presentation takes place every two years at the HIH.

  • Call for Application: HIH Junior Research Group

    The HIH is currently seeking young and highly motivated scientists from all over the world who wish to set up their own independent junior research group. Interested applicants should want to pursue a career in any field of basic, translational or clinical neurosciences that complements and enriches the existing strengths at the HIH. The research group will have full access to cutting-edge scientific infrastructure, state-of-the-art equipment, the University Hospital of Neurology, and the rich collaborative opportunities.

    For more information, please see the job vacancy.

    You can find more open positions in our career section.

  • AI and Medicine

    Artificial intelligence has become an integral part of medical research - but what role does it really play in the race for the future? Professor Dr. Hans-Peter Thier, head of the Department of Cognitive Neurology at the HIH, met with the Hertie Foundation and Professor Dr. Philipp Berens, expert in data science in visual research at the Research Institute of Ophthalmology at the University of Tübingen. In an interview, the neuroscientist and bioinformatician talk about the opportunities and risks involved in the interaction between humans and machines.

    To the interview


  • Neurology and Stroke

    The Department of Neurology and Stroke has the main focuses in neurovascular medicine (vessel diseases of the brain, cerebral stroke), neuro-oncology (brain tumors, brain metastases), neuro-immunology (e.g., multiple sclerosis) and neuro-intensive medicine. ...more information

  • Neurodegenerative Diseases

    The Department of Neurodegenerative Diseases treats in-patients on a ward of about 20 beds and in several out-patient clinics. The clinical focus lies on neurodegenerative diseases such as Parkinson’s disease, the ataxias, spastic paraplegias, and dementias. ...more information

  • Neurology and Epileptology

    The Department of Neurology and Epileptology has a focus on epilepsy and other paroxysmal neurological disorders. In these diseases, the excitability of nerve cells temporarily changes either due to genetic or acquired defects. ...more information

  • Cognitive Neurology

    The Department of Cognitive Neurology provides consultant and outpatient neuropsychological care. Another clinical focus is the treatment of chronic dizziness in the interdisciplinary dizziness center “Südwestdeutsches Schwindelzentrum” operated in conjunction ..more information

  • Cellular Neurology

    Our research focus is on the cellular and molecular mechanisms of brain aging and age-related neurodegenerative diseases, with a special emphasis on the pathogenesis of Alzheimer´s disease and other cerebral proteopathies ...more information

  • Independent Research Groups

    The independent research group at the HIH focuses on the physiology of learning and memory ...more information

Research groups

  • Neurology and Stroke

    Brain Networks and Plasticity

    The human brain possesses the remarkable capacity of reorganization, which is the basis for adapting to constantly changing environmental conditions. This plasticity is of paramount importance ...more information

  • Cognitive Neurology

    Neuropsychology of Action

    The Research Group "Neuropsychology of Action" is dedicated to investigations of human action control. We study clinical impairments of action control and their neural substrates in patients with brain damage ...more information

  • Cellular Neurology

    Experimental Neuroimmunology

    An immune response is part of most neurological diseases, and the development of late-onset Alzheimer's Disease (AD) has been linked to immune related genes and most recently also to epigenetic modifications. ...more information

  • Neurodegenerative Diseases

    Genetics of Parkinson's disease

    Parkinson's syndrome (PS) is the second most common neurodegenerative disease after Alzheimer's dementia. The vast majority of patients are ill with no apparent cause. ...more information

  • Cellular Neurology

    Dementia Research Unit

    The Dementia Research Unit is a clinical research unit of the Department of Cellular Neurology and the Department of Psychiatry. It closely collaborates with the outpatient Memory Clinic. ...more information

  • Neurology and Epileptology

    Clinical Genetics of Paroxysmal Neurological Diseases

    Paroxysmal neurological disorders include a broad spectrum of clinical entities such as migraine, episodic ataxia or myotonia. The research group is focussed on the clinical genetics ...more information

  • Cognitive Neurology

    Neuro-Vestibular Diagnostics

    The complaint of dizziness is highly prevalent but remains often an enigma to the physician in daily practice. Serious diseases potentially accompanied by dizziness like stroke, multiple sclerosis ...more information

  • Cognitive Neurology

    Oculomotor Laboratory

    Playing video-games is a widely distributed leisure activity in our society. In order to estimate the consequences of video-game play, we study the details of eye movements and pupil light responses ... more information

  • Cellular Neurology

    Experimental Neuropathology

    Cerebral proteopathy is a unifying term for cerebral neurodegenerative diseases in which aggregated proteins are abnormally deposited in the brain. The hallmark proteopathy is Alzheimer's disease (AD) ...more information

  • Neurodegenerative Diseases

    Functional Neurogenomics

    Neurodegenerative disorders are associated in a proportion of cases with genetic risk and gene mutations. However, the vast majority of cases of Parkinson’s disease are sporadic and the disease is altogether heterogeneous in symptoms and pathology. ...more information

  • Independent Research Group

    Molecular Brain Development

    The mammalian neocortex is a highly complex and spatially heterogeneous structure, which has expanded significantly in mammalian evolution. Neocortical network function is at the heart of cognitive function ...more info

  • Neurology and Stroke

    Neurological B cell Immunology

    The research group “Neurological B cell Immunology” is focused on the role of B cells in neuro-inflammatory diseases including multiple sclerosis (MS) and ...more information

Research groups

  • Neurodegenerative Diseases

    Clinical Parkinson's Disease Research

    Parkinson's disease (PD) is the second most frequent neurodegenerative disorder after Alzheimer’s disease and affects about 1 to 2 % of individuals over the age of 65. The number is steadily increasing due to demographic changes in Western countries. ...more information

  • Cellular Neurology

    Molecular Imaging Unit

    The Molecular Imaging Unit focuses on the visualization of Alzheimer’s disease (AD) and Parkinson's disease (PD) related changes in model systems using in vivo multiphoton microscopy ...more information

  • Neurology and Stroke

    Molecular Neurooncology

    Three to five of 100.000 people are annually diagnosed with a glioblastoma (GBM), the most malignant brain tumor in adults. Despite aggressive multimodal treatment including surgical resection and ...more information

  •  Unit

    Cellular Neurology

    Molecular Biomarkers Unit

    Processes related to Alzheimer ́s disease (AD) and other age-related neurodegenerative diseases start many years before the onset of the first clinical symptoms. At the moment of the first clinical complaints, the disease has already caused ...more information

  • Neurology and Stroke

    Interdisciplinary Section of Neuro-Oncology

    The projects of the lab are focusing on the biology of brain tumors, especially with targeted individualized therapies, molecular mechanisms in the development of resistance and cell based therapy approaches ...more information

  • Neurology and Epileptology

    Translational Imaging

    The focus of our research group is the structural and functional imaging of neurological diseases with a particular focus on epileptology. We use multi-modal imaging techniques to improve the understanding of disease development ...more information

  • Neurodegenerative Diseases


    Dystonia is the third most common movement disorder, and mutations in a growing number of genes have been identified as causes for hereditary forms in many cases. The aim of the group, which brings together clinical experience ...more information

  • Neurology and Stroke

    Neurophonetics and Translational Neurorehabilitation

    The work group Neurophonetics and Translational Neurorehabilitation is based on a cooperation between the University of Tübingen and a neurological rehabilitation clinic (Fachkliniken Hohenurach). ...more information

  • Neurology and Stroke

    Stroke and Neuroprotection

    The research focus of our Stroke and Neuroprotection Laboratory is to find new and to optimize existing neuroprotective strategies ...more information

  • Neurology and Epileptology

    Experimental Epileptology

    Our research group is interested to unravel the mechanisms of well defined, mainly genetic, neurological, paroxysmal diseases, to understand correlations with clinical symptoms and to find new treatment options. ...more information

  • Cognitive Neurology

    Active Perception Lab

    Humans are tremendously reliant on the sense of vision to interact with their environment. Such interaction often involves the generation of motor outputs ...more information

  • Neurodegenerative Diseases

    Mitochondrial Biology of Parkinson’s Disease

    Neurodegenerative disorders are associated in a proportion of cases with genetic risk and gene mutations. However, the vast majority …more info

  • Neurology and Epileptology

    Neuromuscular Imaging Group

    The group works on different projects concerning nerve imaging, particularly high-resolution ultrasound in neuromuscular disorders ...more information

Research groups

  • Neurology and Epileptology

    Migraines and Primary Headache Disorders

    Our group aims at unraveling the molecular pathophysiology of migraine and other primary headache disorders. ...more information

  • Neurodegenerative Diseases

    Section for Clinical Neurogenetics

    Neurogenetic diseases like cerebellar ataxia, hereditary spastic paraplegia and leukodystrophy are rare disorders. ...more information

  • Neurodegenerative Diseases

    Systems Neurodegeneration

    Our research focuses on the investigation of the genetic basis, systems neuroscience and paradigmatic therapy approaches in ...more information

  • Cognitive Neurology

    Sensorimotor Lab

    The lab addresses a variety of topics that, at first glance, may look disparate. Yet, there is a common denominator ...more information

  • Neurodegenerative Diseases

    Genomic of Rare Movement Disorders

    Our group specializes in rare diseases. A disease is called rare, when it affects no more than 5 of 100,000 people. However, in the grand-scheme of things, rare diseases are not quite so rare ...more information

  • Cognitive Neurology

    Section for Computational Sensomotorics

    The Section for Computational Sensomotorics investigates theoretical principles in the perception and control of motor actions. Research is organized around three main topics ...more information

  • Neurodegenerative Diseases

    Genetics and Epigenetics of Neurodegeneration

    The recent advances in high-throughput genomic technologies have provided an unprecedented amount of genotype, expression and epigenetic data for many human disorders. ...more information

  • Cognitive Neurology

    Section for Neuropsychology

    The Section for Neuropsychology focuses on the investigation of spatial cognition and object recognition in humans. The current issues of our work comprise the action control and sensorimotor coordination ...more information

  • Neurodegenerative Diseases

    Functional Neurogenetics

    Age-related neurodegenerative diseases are a severe and increasingly worrisome burden for our aging population. Most of the chronic neurodegenerative diseases ...more information

  • Independent Research Groups

    Learning and Memory

    All organisms continuously have to adapt their behavior according to changes in the environment in order to survive. This is particularly important when learning to predict threatening or dangerous situations. ...more information

  • Cognitive Neurology

    Systems Neurophysiology Lab

    The overarching goal of our work is to understand the operating principles of the neocortex, a unique brain structure, which mainly evolved in mammals. There is clear evidence that the neocortex, in the broadest sense, endows the subject with cognitive capabilities. ...more information

  • Neurodegenerative Diseases

    Deep Brain Stimulation

    The working group aims to uncover mechanisms of action of deep brain stimulation therapy and to translate the pathophysiological insights into future developments. …more information

  • Cognitive Neurology

    Motor Control Modeling

    The research group „Multi-Level Modeling in Motor Control and Rehabilitation Robotics“ focuses on the generation and control of active biological movements. We develop ...more information

-Neurocolloquium 18:15 Winrich Freiwald (The Rockefeller University, New Yorkl)
The dual face: vision's inroad into the social brain
Location: Children Hospital, Hoppe-Seyler-Str. 1, 3rd Floor, Lecture Hall
-Neurobiological Monday Colloquium 18:00 Drew Robson & Jennifer Li (Max Planck Institute for Biological Cybernetics, Tübingen)
Internal state dynamics shape brain-wide activity and foraging behavior
Location: HIH, Seminarraum 2.310
-Neurocolloquium - GTC Students' Favourites 18:15 Benjamin Grewe (Dept. Informationstechnologie und Elektrotechnik)
Learning representations in deep (brain) neuronal networks
Location: Children Hospital, Hoppe-Seyler-Str. 1, 3rd Floor, Lecture Hall

Combining excellent research and patient care

Click on the image to watch the video

An exemplary connection between research and clinical care

The German Council of Science and Humanities recognizes the performance and academic excellence of theHertie Institute for Clinical Brain Research. The recommendation of the council is an excellent basis for the further development of the HIH. 

Press release by the German Council of Science and Humanities (Wissenschaftsrat)

Press release by the HIH