Laying the foundations for tomorrow's medicine


  • New era in the treatment of epilepsy

    Gene mutations play an increasingly important role in many areas of medicine. Scientists headed by Dr. Markus Wolff and Professor Dr. Holger Lerche at the University Hospital Tübingen and Hertie Institute for Clinical Brain Research have now systematically assigned a therapeutic effect to mutations in a specific gene that triggers epilepsy. This finding will primarily benefit newborns and infants who suffer from severe epileptic seizures as they can now be treated in a targeted manner. Besides it may also be relevant for older patients with such genetic defects. The researchers have published their results in the May issue of the journal BRAIN.

    ... more information (in German only)

  • Science is international

    The Hertie Institute for Clinical Brain Research at the University Hospital Tübingen supports the common statement by German Rectors´ Conference (HRK), Alexander von Humboldt Foundation, German Research Foundation, German Academic Exchange Service, German Council of Science and Humanities, German National Academy of Sciences Leopoldina, Helmholtz Association of German Research Centres, Leibniz Association, Max Planck Society. The institute refuses US President Donald Trump’s order, which is intended to prohibit nationals from seven Muslim countries from entering the United States. The directive puts people at a disadvantage solely because of their ethnicity and attacks the fundamental values of science. Scientific knowledge can only be gained in open, free and international discourse. 

    … more information

  • Dr. Sven Poli is coordinating a European-wide study on neuroprotection in ischemic stroke since January 1, 2017

    In ischemic stroke, brain-supplying arteries are blocked and blood perfusion in parts of the brain is disrupted. This leads to an oxygen deficiency and the affected brain tissue dies over time. Current stroke treatment therefore aims at reopening blocked arteries, which is subject to time limitations.

    Since the beginning of the year, Dr. Sven Poli at the HIH and vice medical director at the Dept. of Neurology & Stroke at the University Hospital Tübingen is coordinating a Europe-wide phase II study on high-dose oxygen therapy in stroke. The researchers want to show whether a rapidly initiated high-dose oxygen therapy may protect threatened brain tissue from dying until the blood circulation is restored. Infarct volume and degree of disability may be minimized in this way. The study is funded by the European Union with EUR 6 million and involves 12 clinical centers in 8 European countries.

  • Dr. Daniel Häufle is a new research group leader at the HIH

    Daniel Häufle develops models and computer simulations for biological movements. The physicist wants to understand how movements are controlled and why some neurological disorders lead to movement disorders. His research findings are applied in the development of asisstive devices. Häufle makes use of an interdisciplinary and multi-level approach, considering biophysics, biomechanics. His computational procedures take different hierarchy-levels of movement control into account. Coming from the excellence cluster SimTech at the University of Stuttgart, Häufle will now head a junior research group at the HIH. His group will be part of the "System Human" research alliance between the Universities of Tübingen and Stuttgart, which is funded by the Ministry of Science, Research and Art of the State of Baden-Württemberg.

  • Brain activity of a younger test subject doing spatial memory tasks – left side: solving a simple task, right side: solving a very difficult task.
    Copyright: Axel Lindner

    Not of divided mind

    As we get older, our brain mobilises additional capacity whenever it is particularly challenged. According to the current paradigm, the aging brain makes use of areas in both hemispheres, while only using one hemisphere for each task at a younger age. A team of researchers at the department of cognitive neurology at the Hertie Institute for Clinical Brain Research (HIH) led by Dr Axel Lindner has now investigated specifically when this mechanism is engaged. Employing functional magnetic resonance imaging (fMRI), they observed the dorsolateral prefrontal cortex (dlPFC), a brain area responsible for memory tasks. They found that the dlPFC is active in both hemispheres whenever faced with especially difficult tasks – not only in elderly but also in younger people.

    ...more information

  • Martin Suter was inspired by Mathias Jucker in his new novel "Elefant"

    In the epilogue to his recently published novel "Elefant", Martin Suter says that he could not lay to rest the idea that it is possible to produce a tiny pink elephant by genetic engineering. The image first arouse during a discussion with Prof. Dr. Mathias Jucker from the Hertie Institute for Clinical Brain Research (HIH) at the University Hospital Tübingen and the German Center for Neurodegenerative Diseases (DZNE) during an international Alzheimer´s congress in Tübingen. Being very close to scientific possibilites, Suter´s new novel is a  superb parable about the uniqueness of creation and responsibility in science.

    … more information (in German only)

  • Hertie Institute for Clinical Brain Research celebrates 15th anniversary

    On Dec 1, 2016, the Hertie Institute for Clinical Brain Research celebrated its 15th anniversary. For his commitment to founding and developing the institute, the long-serving chairman of the non-profit Hertie Foundation, Dr. Michael Endres, was honored with the Leonhart Fuchs medal of the Faculty of Medicine Tübingen. Without his personal dedication and the generous support from the Hertie Foundation, the HIH would not have become the model for health care at university clinics in Germany, said Professor Johannes Dichgans, founding director of the HIH to an invited audience of about sixty guests in Tübingen.

    ... more information (in German only)

    Image: Presentation of the Leonhart Fuchs medal by Prof. Dr. Ingo Autenrieth, Dean of the Faculty of Medicine, to Dr. Michael Endres, long-term chairman of the Hertie Foundation

  • How the brain perceives causal relationships

    A research team headed by Professor Dr. Martin Giese and Professor Dr. Hans-Peter Thier at the Department of Cognitive Neurology have discovered that mirror neurons are involved in the perception of causality.

    ... more information (in German only)

  • A pioneer of non-invasive brain stimulation remains at the Hertie Institute for Clinical Brain Research

    Professor Dr. Ulf Ziemann, director of the Department of Neurology and Stroke at University Hospital Tübingen and director at the Hertie Institute for Clinical Brain Research (HIH) has rejected the appointment to a W3 professorship for neurology at Hannover Medical School. There, he would have been singular director and chairman of the Clinic for Neurology. However, Ziemann decided to stay in Tübingen. When asked about his decision, the neurologist pointed to the unique neuroscientific environment in Tübingen. The HIH is part of a unique neuroscience campus in Germany, which further embraces the Centre for Integrative Neuroscience (CIN), the Tübingen site of the German Center for Neurodegenerative Diseases (DZNE), and the Department of Neurology at University Hospital Tübingen. 

    … more information
     (in German only)

  • Professor Dr. Yvonne Weber receives Heinrich Pette Award 2016

    Neurologist and epileptologist Yvonne Weber from the Hertie Institute for Clinical Brain Research at University Hospital Tübingen has received this year's Heinrich Pette Award from the German Society of Neurology (DGN). The professor, who works at the Department of Neurology and Epileptology, was awarded at the 89th meeting of the society in Mannheim. The prize is presented annually to aspiring scientists and is endowed with 10,000 euros. It recognizes outstanding achievements in the field of neurology. 

    … more information (in German only)

    From left to right: Professor Stefan Schwab, chairman of the DGN Meeting 2016, Professor Yvonne Weber, awardee, Professor Ralf Gold, president of the DGN

  • "We want to treat the very early brain changes“

    September 21 marks World Alzheimer’s Day, a day to raise global awareness to the disease and the situation of those affected and their families. Prof. Dr. Mathias Jucker, researcher at the Hertie Institute for Clinical Brain Research, is working on a therapeutic approach against the early brain changes. The non-profit Hertie Foundation, which has supported the HIH with about 37 million euros up to now, spoke with Jucker about his current projects as well as his way of doing research. 

    … more information (in German only)

  • Sigmund Kiener Stiftung supports HIH

    Over the next three years, the Hertie Institute for Clinical Brain Research (HIH) at Tübingen University Hospital receives a total of 75,000 euros from the Sigmund Kiener Stiftung in Baden-Baden, hereby enabling three Sigmund Kiener doctoral fellowships for students of human medicine. 

    This generous funding supports the HIH in a major concern. By means of a superior medical doctorate, the HIH aims to give doctors-to-be the opportunity to pursue a career as „clinician scientist". These physicians feel at home in the hospital as well as in basic medical research.

    … more information (in German only)


  • Neurology and Stroke

    The Department of Neurology and Stroke has the main focuses in neurovascular medicine (vessel diseases of the brain, cerebral stroke), neuro-oncology (brain tumors, brain metastases), neuro-immunology (e.g., multiple sclerosis) and neuro-intensive medicine. ...more information

  • Neurodegenerative Diseases

    The Department of Neurodegenerative Diseases treats in-patients on a ward of about 20 beds and in several out-patient clinics. The clinical focus lies on neurodegenerative diseases such as Parkinson’s disease, the ataxias, spastic paraplegias, and dementias. ...more information

  • Neurology and Epileptology

    The Department of Neurology and Epileptology has a focus on epilepsy and other paroxysmal neurological disorders. In these diseases, the excitability of nerve cells temporarily changes either due to genetic or acquired defects. ...more information

  • Cognitive Neurology

    The Department of Cognitive Neurology provides consultant and outpatient neuropsychological care. Another clinical focus is the treatment of chronic dizziness in the interdisciplinary dizziness center “Südwestdeutsches Schwindelzentrum” operated in conjunction ..more information

  • Cellular Neurology

    The focus of the Department of Cellular Neurology lies on cellular and molecular mechanisms in the aging brain and age-related neurodegenerative diseases. Special emphasis is placed on Alzheimer's disease, the most common and severe form of senile dementia. ...more information

  • Independent Research Groups

    There are two independent research group at the HIH. One of their research focus is the molecular and cellular mechanisms of axon regeneration and neuronal differentiation during repair after damage to the central nervous system (CNS). A second research focus comprises ...more information

Research groups

  • Neurology and Stroke

    Brain Networks and Plasticity

    Das menschliche Gehirn besitzt eine erstaunliche Fähigkeit zur Reorganisation, die Voraussetzung für die Anpassung an sich ständig ändernde Umweltbedingungen ist. Diese Fähigkeit zur Plastizität ...more information

  • Neurology and Epileptology

    Functional Neuronal Networks

    Neuronal network activity can be assessed by the microelectrode array (MEA) technology that allows simultaneous recording of the electrical activity exhibited by entire populations of neurons over several weeks or months in vitro. ...more information

  • Cognitive Neurology

    Neuropsychology of Action

    The Research Group "Neuropsychology of Action" is dedicated to investigations of human action control. We study clinical impairments of action control and their neural substrates in patients with brain damage ...more information

  • Cellular Neurology

    Experimental Neuroimmunology

    An immune response is part of most neurological diseases, and the development of late-onset Alzheimer's Disease (AD) has been linked to immune related genes and most recently also to epigenetic modifications. ...more information

  • Neurodegenerative Diseases

    Genetics of Parkinson's disease

    Das Parkinson Syndrom (PS) ist nach der Alzheimer-Demenz die zweithäufigste neurodegenerative Erkrankung. Die große Mehrzahl der Patienten erkrankt ohne erkennbare Ursache. Bei einem kleinen Teil der Patienten ...more information

  • Cellular Neurology

    Section for Dementia Research

    The Section for Dementia Research of the Department of Cellular Neurology and the University Clinic for Psychiatry and Psychotherapy is headed by Prof. Dr. Christoph Laske. The section consists ...more information

  • Neurology and Stroke


    Our research group investigates the role of the immune system in inflammatory diseases of the central nervous system (CNS) and stroke. We are particularly interested in finding out which immune cells are ...more information

  • Neurology and Epileptology

    Clinical Genetics of Paroxysmal Neurological Diseases

    Der Überbegriff der paroxysmalen neurologischen Erkrankungen beinhaltet ein breites Spektrum an klinischen Entitäten mit episodischem Auftreten von Störungen des Nervensystems....more information

  • Cognitive Neurology

    Neuro-Vestibular Diagnostics

    The complaint of dizziness is highly prevalent but remains often an enigma to the physician in daily practice. Serious diseases potentially accompanied by dizziness like stroke, multiple sclerosis ...more information

  • Cognitive Neurology

    Oculomotor Laboratory

    Playing video-games is a widely distributed leisure activity in our society. In order to estimate the consequences of video-game play, we study the details of eye movements and pupil light responses ... more information

  • Cellular Neurology

    Experimental Neuropathology

    Cerebral proteopathy is a unifying term for cerebral neurodegenerative diseases in which aggregated proteins are abnormally deposited in the brain. The hallmark proteopathy is Alzheimer's disease (AD) ...more information

  • Independent Research Groups


    Our research focuses on the molecular and cellular mechanisms of axon regeneration and neuronal differentiation for the repair of central nervous system (CNS) damage, with particular emphasis ...more information

  • Neurodegenerative Diseases

    Functional Neurogenomics

    Die Forschungsgruppe befasst sich mit verschiedenen Fragen der molekularen Pathogenese und experimentellen Therapie neurodegenerativer Erkrankungen. Im Vordergrund steht dabei die Erforschung ..more information

Research groups

  • Neurodegenerative Diseases

    Clinical Neurodegeneration

    Die Forschungsgruppe "Klinische Neurodegeneration" befasst sich mit häufig vorkommenden neurodegenerativen Erkrankungen, v.a. der Parkinsonerkrankung und Demenzerkrankungen, die mit Bewegungsstörungen einhergehen. ...more information

  • Cellular Neurology

    Molecular Imaging

    The Molecular Imaging group focuses on the visualization of Alzheimer's disease (AD) related changes in the brain of mouse models using in vivo multiphoton microscopy. A solid knowledge of the dynamics of amyloid lesions and ...more information

  • Neurology and Stroke

    Molecular Neurooncology

    Three to five of 100.000 people are annually diagnosed with a glioblastoma (GBM), the most malignant brain tumor in adults. Despite aggressive multimodal treatment including surgical resection and ...more information

  • Neurology and Epileptology

    Functional Epilepsy Genetics

    Our research focus is on two ion channel groups with a prominent role in the regulation of excitability, the neuronal Kv7 channels and the GABA(A) receptors. A number of genetic alterations detected in recent years in the corresponding KCNQ2/3 ...more information

  • Cognitive Neurology

    Neurobiology of Sensorimotor Decision Making

    Given the vast number of behavioral options that are usually available in an everyday life situation, how do we - and thus our brain - decide which option to go for ...more information

  • Neurodegenerative Diseases

    Functional Neurogeriatrics

    Die Forschungsgruppe funktionelle Neurogeriatrie untersucht motorische Funktionseinschränkungen bei Älteren und Patienten mit neurodegenerativen Erkrankungen. Es kommen dabei modernste Detektionssysteme ...more information

  • Cellular Neurology

    Fluid Disease Biomarkers

    Processes related to Alzheimer ́s disease (AD) and other age-related neurodegenerative diseases start many years before the onset of the first clinical symptoms. At the moment of the first clinical complaints, the disease has already caused ...more information

  • Neurology and Stroke

    Clinical and Experimental Neurooncology

    Die Projekte des Labors für Klinische und Experimentelle Neuroonkologie befassen sich mit der Biologie von Hirntumoren, mit speziellem Fokus auf zielgerichteten individualisierten therapeutischen Angriffspunkten ...more information

  • Neurology and Epileptology

    Translational Imaging

    Der Schwerpunkt unserer Forschungsgruppe ist die strukturelle und funktionelle Bildgebung neurologischer Erkrankungen mit besonderem Fokus auf die Epileptologie. Wir nutzen die technischen Methoden multi-modaler Bildgebung ...more information

  • Neurodegenerative Diseases


    Dystonia is the third most common movement disorder, and mutations in a growing number of genes have been identified as causes for hereditary forms in many cases. The aim of the group, which brings together clinical experience ...more information

  • Neurology and Stroke

    Neurophonetics and Translational Neurorehabilitation

    The work group Neurophonetics and Translational Neurorehabilitation is based on a cooperation between the Universitäty of Tübingen and a neurological rehabilitation clinic (Fachkliniken Hohenurach). ...more information

  • Neurology and Stroke

    Stroke and Neuroprotection

    The research focus of our Stroke and Neuroprotection Laboratory is to find new and to optimize existing neuroprotective strategies ...more information

  • Neurology and Epileptology

    Experimental Epileptology

    Our research group is interested to unravel the mechanisms of well defined, mainly genetic, neurological, paroxysmal diseases, to understand correlations with clinical symptoms and to find new treatment options. ...more information

Research groups

  • Neurology and Epileptology

    Migraines and Primary Headache Disorders

    Unsere Arbeitsgruppe beschäftigt sich mit der Entschlüsselung der Genetik und molekularen Pathophysiologie der Migräne und anderer primärer Kopfschmerzerkrankungen. ...more information

  • Neurodegenerative Diseases

    Section for Clinical Neurogenetics

    Neurogenetic diseases like cerebellar ataxia, hereditary spastic paraplegia and leukodystrophy are rare disorders. ...more information

  • Neurodegenerative Diseases

    Systems Neurodegeneration

    Our research focuses on the investigation of the genetic basis, systems neuroscience and paradigmatic therapy approaches in ...more information

  • Cognitive Neurology

    Sensorimotor Lab

    The lab addresses a variety of topics that, at first glance, may look disparate. Yet, there is a common denominator ...more information

  • Neurodegenerative Diseases

    Genomic of Rare Diseases

    Seltene Erkrankungen sind also eine enorme Herausforderung und die Medizin und erfordern von uns Klinikern und Wissenschaftlern, Fachleute für Spezialfälle zu sein. Das Schlagwort Präzisionsmedizin - im Alltag der seltenen Erkrankungen ist es längst angekommen ...more Information

  • Cognitive Neurology

    Section for Computational Sensomotorics

    The Section for Computational Sensomotorics investigates theoretical principles in the perception and control of motor actions. Research is organized around three main topics ...more information

  • Neurodegenerative Diseases

    Genetics and Epigenetics of Neurodegeneration

    The recent advances in high-throughput genomic technologies have provided an unprecedented amount of genotype, expression and epigenetic data for many human disorders. ...more information

  • Cognitive Neurology

    Section for Neuropsychology

    The Section for Neuropsychology focuses on the investigation of spatial cognition and object recognition in humans. The current issues of our work comprise the action control and sensorimotor coordination ...more information

  • Cellular Neurology

    Amyloid Biology

    The group studies mechanisms of amyloid formation in particular the molecular nature of pathogenic protein aggregation. ...more information

  • Neurodegenerative Diseases

    Functional Neurogenetics

    Age-related neurodegenerative diseases are a severe and increasingly worrisome burden for our aging population. Most of the chronic neurodegenerative diseases ...more information

  • Independent Research Groups

    Learning and Memory

    Unser Ziel ist es, molekulare, synaptische und zelluläre Prozesse in der Amygdala und mit ihr assoziierter Gehirnregionen, die an der Steuerung von Furcht und der Speicherung von Furchtgedächtnis beteiligt sind, zu identifizieren. ...more information

  • Cognitive Neurology

    Systems Neurophysiology Lab

    The overarching goal of our work is to understand the operating principles of the neocortex, a unique brain structure, which mainly evolved in mammals. There is clear evidence that the neocortex, in the broadest sense, endows the subject with cognitive capabilities. ...more information

  • Neurodegenerative Diseases

    Deep Brain Stimulation

    The working group aims to uncover mechanisms of action of deep brain stimulation therapy and to translate the pathophysiological insights into future developments. …more information

  • Cognitive Neurology

    Motor Control Modeling

    The research group „Multi-Level Modeling in Motor Control and Rehabilitation Robotics“ focuses on the generation and control of active biological movements. We develop ...more information

FAZ "Warum wir Alzheimer immer noch nicht heilen können" (01.02.2017)
Press article by Prof. Dr. Mathias Jucker (in German)

-Therapieseminar der Neurologischen Klinik 17:00 Dr. Brockmann, C. Deuschle, Dr. Schüle, Dr. Schulte
Neurobiobank Tübingen: Ziele, Struktur und praktische Abläufe für die Einspeisung
Raum B-04-221 (CRONA)
-The HER Seminar Series 12:00 h Jennifer Ewald (Interfaculty Institute of Cell Biology (IFIZ), University of Tübingen)
Title: Linking metabolic and cell cycle regulation
Ort: DZNE, Seminarraum 3.602 B
-Wissenschaftliches Kolloquium 17:00 Prof. Julia Jacobs, Freiburg
Neue Methoden in der Epilepsiediganostik: Hochfrequenzoszillationen und fast FMRTSequenzen
Raum B-04-221 (CRONA)

An exemplary connection between research and clinical care

The German Council of Science and Humanities recognizes the performance and academic excellence of theHertie Institute for Clinical Brain Research. The recommendation of the council is an excellent basis for the further development of the HIH. 

Press release by the German Council of Science and Humanities (Wissenschaftsrat)

Press release by the HIH