Laying the foundations for tomorrow's medicine

News

  • Federal Minister of Health Gröhe visit the Hertie Institute for Clinical Brain Research

    On August 30, 2017, the Federal Minister of Health Hermann Gröhe and the Parliamentary Secretary of State Annette Widmann-Mauz came to see the Hertie Institute for Clinical Brain Research during a visit at the University Hospital Tübingen. Starting at the German Center for Neurodegenerative Diseases (DZNE), the neurosciences were the focus of the visit. At the Hertie Institute, Dr. Winfried Ilg and PD Dr. Matthis Synofzik informed the visitors how video games may improve movement disorders in ataxia patients. The neuroscientists measure the progress by means of video recordings, which allow a detailed analysis of the movements in three-dimensional space. 

    ...more info 

    Photo: Analysing the moments of Federal Minister of Health Hermann Gröhe (Universität Tübingen/Friedhelm Albrecht)

  • Professor Dr. Dr. Tabtabai is one of the best neuro-oncologists

    Professor Dr. Dr. Ghazaleh Tabatabai is one of the top neuro-oncologists in Germany. This is the result of a current survey among medical specialists and registered doctors that has been appointed by the German news magazine Focus. The journal has now published a list of the best physicians 2017 in a special edition on cancer. 

    “Of course, it is a privilege to to receive this award on behalf of my whole team,“ says Tabatabai. “It reveals that patients and doctors in Germany acknowledge our clinical work.” In her research group at the HIH, the physician investigates basic science questions. “We seek for possibilities to develop new forms of a targeted and individualized therapies for our patients.” ...more info

     

     

  • Why a diabetes drug could help in Parkinson’s Disease

    A diabetes drug might help in certain types of Parkinson’s disease, reports a team headed by Dr. Julia Fitzgerald at the Hertie Institute for Clinical Brain Research, the University of Tübingen and the German Center for Neurodegenerative Diseases in Tübingen. The neuroscientists identified a protein that plays an important role in the energy balance of cells. If the protein is missing, the energy balance is disturbed leading possibly to cell death and ultimately to the onset of the disease. In Parkinson’s disease, nerve cells die off in a brain area responsible for movement control. Using cell cultures, the research team has now shown that the diabetes drug metformin acts on the energy budget, thereby protecting the cells. The study has been published in the current issue of the journal Brain.

    ...more info

  • The brain’s defense cells live longer than expected

    Eliminating pathogens and cellular waste—this is an important task of microglia cells, the immune cells of the brain. They belong to the group of non-neural brain cells that support the normal function of nerve cells. A new study now shows that in mice these scavenger cells may live as long as the rodents themselves. The new finding comes from scientists at the Hertie Institute for Clinical Brain Research, the University of Tübingen, and the German Center for Neurodegenerative Diseases (DZNE). In an advance online publication of the journal Nature Neuroscience the scientists followed individual microglia cells under the microscope in vivo. The unexpectedly long lifespan of microglia indicates further functions these cells may perform: “Their longevity allows them to learn and to age,” explains Professor Dr. Mathias Jucker. “This may enable them to form an immunological memory and contribute to the development of neurodegenerative diseases.”

    ... more info

  • Dr. Astrid Proksch becomes new managing director at the Hertie Foundation

    Starting September 1st, the science manager with a PhD in biochemistry will be responsible for the program “Brain Research” of the non-profit foundation. She continues to be administrative director of the Hertie Institute for Clinical Brain Research (HIH).

    “I am looking forward to the new challenges and in particular the change of perspective,” explains Dr. Astrid Proksch. “The task area is very broad and allows me to give new impulses.” In the future, she intends to intensify synergies between the HIH and the Hertie Foundation and help to create new concepts to promote brain research in Germany. To this end, she plans to further develop the program “Brain Research” of the foundation.

    … more info (in German only)

  • Neuroscience Campus Get Together 2017

    The “HIH Paper of the Year Award”, a kicker tournament and getting together with colleagues while enjoying delicious street food: this is what the Neuroscience Campus Get Together is about, which is jointly organized by the Hertie Institute, the Centre for Integrative Neuroscience (CIN), the German Center for Neurodegenerative Diseases (DZNE) and the Clinic of Neurology at the University Hospital Tübingen. On July 26, 2017, the Get Together was celebrated for the third time.

    One of its highlights was the presentation of the “HIH Paper of the Year Award” for the best scientific publication from HIH of the previous year. The award was presented to Mehtap Bacioglu from the research group "Experimental Neuropathology" for her discovery of the neurofilament light chain protein as a biomarker for neurodegenerative diseases in the mouse model and in patients. ... more info

    Photo: The awardee with Prof. Dr. Dichgans

Departments

  • Neurology and Stroke

    The Department of Neurology and Stroke has the main focuses in neurovascular medicine (vessel diseases of the brain, cerebral stroke), neuro-oncology (brain tumors, brain metastases), neuro-immunology (e.g., multiple sclerosis) and neuro-intensive medicine. ...more information

  • Neurodegenerative Diseases

    The Department of Neurodegenerative Diseases treats in-patients on a ward of about 20 beds and in several out-patient clinics. The clinical focus lies on neurodegenerative diseases such as Parkinson’s disease, the ataxias, spastic paraplegias, and dementias. ...more information

  • Neurology and Epileptology

    The Department of Neurology and Epileptology has a focus on epilepsy and other paroxysmal neurological disorders. In these diseases, the excitability of nerve cells temporarily changes either due to genetic or acquired defects. ...more information

  • Cognitive Neurology

    The Department of Cognitive Neurology provides consultant and outpatient neuropsychological care. Another clinical focus is the treatment of chronic dizziness in the interdisciplinary dizziness center “Südwestdeutsches Schwindelzentrum” operated in conjunction ..more information

  • Cellular Neurology

    The focus of the Department of Cellular Neurology lies on cellular and molecular mechanisms in the aging brain and age-related neurodegenerative diseases. Special emphasis is placed on Alzheimer's disease, the most common and severe form of senile dementia. ...more information

  • Independent Research Groups

    There are two independent research group at the HIH. One of their research focus is the molecular and cellular mechanisms of axon regeneration and neuronal differentiation during repair after damage to the central nervous system (CNS). A second research focus comprises ...more information

Research groups

  • Neurology and Stroke

    Brain Networks and Plasticity

    The human brain possesses the remarkable capacity of reorganization, which is the basis for adapting to constantly changing environmental conditions. This plasticity is of paramount importance ...more information

  • Cognitive Neurology

    Neuropsychology of Action

    The Research Group "Neuropsychology of Action" is dedicated to investigations of human action control. We study clinical impairments of action control and their neural substrates in patients with brain damage ...more information

  • Cellular Neurology

    Experimental Neuroimmunology

    An immune response is part of most neurological diseases, and the development of late-onset Alzheimer's Disease (AD) has been linked to immune related genes and most recently also to epigenetic modifications. ...more information

  • Neurodegenerative Diseases

    Genetics of Parkinson's disease

    Parkinson's syndrome (PS) is the second most common neurodegenerative disease after Alzheimer's dementia. The vast majority of patients are ill with no apparent cause. ...more information

  • Cellular Neurology

    Section for Dementia Research

    The Section for Dementia Research of the Department of Cellular Neurology and the University Clinic for Psychiatry and Psychotherapy is headed by Prof. Dr. Christoph Laske. The section consists ...more information

  • Neurology and Epileptology

    Clinical Genetics of Paroxysmal Neurological Diseases

    Paroxysmal neurological disorders include a broad spectrum of clinical entities such as migraine, episodic ataxia or myotonia. The research group is focussed on the clinical genetics ...more information

  • Cognitive Neurology

    Neuro-Vestibular Diagnostics

    The complaint of dizziness is highly prevalent but remains often an enigma to the physician in daily practice. Serious diseases potentially accompanied by dizziness like stroke, multiple sclerosis ...more information

  • Cognitive Neurology

    Oculomotor Laboratory

    Playing video-games is a widely distributed leisure activity in our society. In order to estimate the consequences of video-game play, we study the details of eye movements and pupil light responses ... more information

  • Cellular Neurology

    Experimental Neuropathology

    Cerebral proteopathy is a unifying term for cerebral neurodegenerative diseases in which aggregated proteins are abnormally deposited in the brain. The hallmark proteopathy is Alzheimer's disease (AD) ...more information

  • Independent Research Groups

    Neuroregeneration

    Our research focuses on the molecular and cellular mechanisms of axon regeneration and neuronal differentiation for the repair of central nervous system (CNS) damage, with particular emphasis ...more information

  • Neurodegenerative Diseases

    Functional Neurogenomics

    Neurodegenerative disorders are associated in a proportion of cases with genetic risk and gene mutations. However, the vast majority of cases of Parkinson’s disease are sporadic and the disease is altogether heterogeneous in symptoms and pathology. ...more information

Research groups

  • Neurodegenerative Diseases

    Clinical Neurodegeneration

    Parkinson's disease (PD) is the second most frequent neurodegenerative disorder after Alzheimer’s disease and affects about 1 to 2 % of individuals over the age of 65. The number is steadily increasing due to demographic changes in Western countries. ...more information

  • Cellular Neurology

    Molecular Imaging

    The Molecular Imaging group focuses on the visualization of Alzheimer's disease (AD) related changes in the brain of mouse models using in vivo multiphoton microscopy. A solid knowledge of the dynamics of amyloid lesions and ...more information

  • Neurology and Stroke

    Molecular Neurooncology

    Three to five of 100.000 people are annually diagnosed with a glioblastoma (GBM), the most malignant brain tumor in adults. Despite aggressive multimodal treatment including surgical resection and ...more information

  • Cognitive Neurology

    Neurobiology of Sensorimotor Decision Making

    Given the vast number of behavioral options that are usually available in an everyday life situation, how do we - and thus our brain - decide which option to go for ...more information

  • Neurodegenerative Diseases

    Functional Neurogeriatrics

    Die Forschungsgruppe funktionelle Neurogeriatrie untersucht motorische Funktionseinschränkungen bei Älteren und Patienten mit neurodegenerativen Erkrankungen. Es kommen dabei modernste Detektionssysteme ...more information

  • Cellular Neurology

    Fluid Disease Biomarkers

    Processes related to Alzheimer ́s disease (AD) and other age-related neurodegenerative diseases start many years before the onset of the first clinical symptoms. At the moment of the first clinical complaints, the disease has already caused ...more information

  • Neurology and Stroke

    Interdisciplinary Section of Neuro-Oncology

    Die Projekte des Labors für Klinische und Experimentelle Neuroonkologie befassen sich mit der Biologie von Hirntumoren, mit speziellem Fokus auf zielgerichteten individualisierten ...more information

  • Neurology and Epileptology

    Translational Imaging

    The focus of our research group is the structural and functional imaging of neurological diseases with a particular focus on epileptology. We use multi-modal imaging techniques to improve the understanding of disease development ...more information

  • Neurodegenerative Diseases

    Dystonia

    Dystonia is the third most common movement disorder, and mutations in a growing number of genes have been identified as causes for hereditary forms in many cases. The aim of the group, which brings together clinical experience ...more information

  • Neurology and Stroke

    Neurophonetics and Translational Neurorehabilitation

    The work group Neurophonetics and Translational Neurorehabilitation is based on a cooperation between the University of Tübingen and a neurological rehabilitation clinic (Fachkliniken Hohenurach). ...more information

  • Neurology and Stroke

    Stroke and Neuroprotection

    The research focus of our Stroke and Neuroprotection Laboratory is to find new and to optimize existing neuroprotective strategies ...more information

  • Neurology and Epileptology

    Experimental Epileptology

    Our research group is interested to unravel the mechanisms of well defined, mainly genetic, neurological, paroxysmal diseases, to understand correlations with clinical symptoms and to find new treatment options. ...more information

Research groups

  • Neurology and Epileptology

    Migraines and Primary Headache Disorders

    Our group aims at unraveling the molecular pathophysiology of migraine and other primary headache disorders. ...more information

  • Neurodegenerative Diseases

    Section for Clinical Neurogenetics

    Neurogenetic diseases like cerebellar ataxia, hereditary spastic paraplegia and leukodystrophy are rare disorders. ...more information

  • Neurodegenerative Diseases

    Systems Neurodegeneration

    Our research focuses on the investigation of the genetic basis, systems neuroscience and paradigmatic therapy approaches in ...more information

  • Cognitive Neurology

    Sensorimotor Lab

    The lab addresses a variety of topics that, at first glance, may look disparate. Yet, there is a common denominator ...more information

  • Neurodegenerative Diseases

    Genomic of Rare Movement Disorders

    Our group specializes in rare diseases. A disease is called rare, when it affects no more than 5 of 100,000 people. However, in the grand-scheme of things, rare diseases are not quite so rare ...more information

  • Cognitive Neurology

    Section for Computational Sensomotorics

    The Section for Computational Sensomotorics investigates theoretical principles in the perception and control of motor actions. Research is organized around three main topics ...more information

  • Neurodegenerative Diseases

    Genetics and Epigenetics of Neurodegeneration

    The recent advances in high-throughput genomic technologies have provided an unprecedented amount of genotype, expression and epigenetic data for many human disorders. ...more information

  • Cognitive Neurology

    Section for Neuropsychology

    The Section for Neuropsychology focuses on the investigation of spatial cognition and object recognition in humans. The current issues of our work comprise the action control and sensorimotor coordination ...more information

  • Cellular Neurology

    Amyloid Biology

    The group studies mechanisms of amyloid formation in particular the molecular nature of pathogenic protein aggregation. ...more information

  • Neurodegenerative Diseases

    Functional Neurogenetics

    Age-related neurodegenerative diseases are a severe and increasingly worrisome burden for our aging population. Most of the chronic neurodegenerative diseases ...more information

  • Independent Research Groups

    Learning and Memory

    All organisms continuously have to adapt their behavior according to changes in the environment in order to survive. This is particularly important when learning to predict threatening or dangerous situations. ...more information

  • Cognitive Neurology

    Systems Neurophysiology Lab

    The overarching goal of our work is to understand the operating principles of the neocortex, a unique brain structure, which mainly evolved in mammals. There is clear evidence that the neocortex, in the broadest sense, endows the subject with cognitive capabilities. ...more information

  • Neurodegenerative Diseases

    Deep Brain Stimulation

    The working group aims to uncover mechanisms of action of deep brain stimulation therapy and to translate the pathophysiological insights into future developments. …more information

  • Cognitive Neurology

    Motor Control Modeling

    The research group „Multi-Level Modeling in Motor Control and Rehabilitation Robotics“ focuses on the generation and control of active biological movements. We develop ...more information

FAZ "Das Zittern hat eine Geschichte" (17.05.2017)
Press article by Prof. Dr. Thomas Gasser (in German)

FAZ "Warum wir Alzheimer immer noch nicht heilen können" (01.02.2017)
Press article by Prof. Dr. Mathias Jucker (in German)

Events
-Tübingen International Summer School (TISS) 2017 Neural Prosthetics: From Restoration to Enhancement of Biological Systems?
Perspectives from Science, Ethics and Philosophy

September 24-27, Cloister Heiligkreuztal

More information: http://www.forum-scientiarum.uni-tuebingen.de/studium/akademien/archiv/tiss2017.html
-Wissenschaftliches Kolloquium 17:00 Dr. Robin Wagener, Genf/Schweiz
Good neighbourly relations: The importance of relative neuronal positions in development and adult function of the neocortex
Raum B-04-221 (CRONA)

An exemplary connection between research and clinical care

The German Council of Science and Humanities recognizes the performance and academic excellence of theHertie Institute for Clinical Brain Research. The recommendation of the council is an excellent basis for the further development of the HIH. 

Press release by the German Council of Science and Humanities (Wissenschaftsrat)

Press release by the HIH